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Visual, Auditory, and Cross Modal Sensory Processing in Adults with Autism: An EEG Power and BOLD fMRI Investigation.

Hames EC, Murphy B, Rajmohan R, Anderson RC, Baker M, Zupancic S, O'Boyle M, Richman D - Front Hum Neurosci (2016)

Bottom Line: Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28.Analysis focused on EEG power, BOLD fMRI, and accuracy.Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical and Computer Engineering, Texas Tech University, Lubbock TX, USA.

ABSTRACT
Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28. We hypothesized that ASD performance on combined audiovisual trials would be less accurate with observable decreased EEG power across frontal, temporal, and occipital channels and decreased BOLD fMRI activity in these same regions; reflecting deficits in key sensory processing areas. Analysis focused on EEG power, BOLD fMRI, and accuracy. Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

No MeSH data available.


Related in: MedlinePlus

Session 2 AA_MM2-AA2 Control > ASD significant fMRI activations. Axial cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the axial planes (blue lines; top row). Coronal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the coronal planes (blue lines; middle row). Sagittal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A coronal cross section depicts the location of the sagittal planes (blue lines; bottom row). The corresponding Brodmann area for significant area of activation is listed in the table at bottom (under the heading “L5”). Statistical significance were based on a FWE corrected p-value threshold of p < 0.05 and k = 5 voxel threshold.
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Figure 10: Session 2 AA_MM2-AA2 Control > ASD significant fMRI activations. Axial cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the axial planes (blue lines; top row). Coronal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the coronal planes (blue lines; middle row). Sagittal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A coronal cross section depicts the location of the sagittal planes (blue lines; bottom row). The corresponding Brodmann area for significant area of activation is listed in the table at bottom (under the heading “L5”). Statistical significance were based on a FWE corrected p-value threshold of p < 0.05 and k = 5 voxel threshold.

Mentions: Finally, the same methodology was used to create contrast maps to observe the effects of multimodal stimulus presentation during session 2. From this, AA_MM2-AA2 was the only contrast map to show significance. As seen in Figure 10, it showed greater activity in the NT than ASD group for the right fusiform gyrus (BA 37R). This contrast consists of activation during the second presentation of a sequence of two multimodal stimuli minus the second presentation in a sequence of two audio stimuli. In this case the multimodal stimuli were surprise stimuli that were applied to only a small percentage of a larger stimulus block made of mostly sequences of two audio stimuli followed by another sequence of two audio stimuli.


Visual, Auditory, and Cross Modal Sensory Processing in Adults with Autism: An EEG Power and BOLD fMRI Investigation.

Hames EC, Murphy B, Rajmohan R, Anderson RC, Baker M, Zupancic S, O'Boyle M, Richman D - Front Hum Neurosci (2016)

Session 2 AA_MM2-AA2 Control > ASD significant fMRI activations. Axial cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the axial planes (blue lines; top row). Coronal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the coronal planes (blue lines; middle row). Sagittal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A coronal cross section depicts the location of the sagittal planes (blue lines; bottom row). The corresponding Brodmann area for significant area of activation is listed in the table at bottom (under the heading “L5”). Statistical significance were based on a FWE corrected p-value threshold of p < 0.05 and k = 5 voxel threshold.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835455&req=5

Figure 10: Session 2 AA_MM2-AA2 Control > ASD significant fMRI activations. Axial cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the axial planes (blue lines; top row). Coronal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the coronal planes (blue lines; middle row). Sagittal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A coronal cross section depicts the location of the sagittal planes (blue lines; bottom row). The corresponding Brodmann area for significant area of activation is listed in the table at bottom (under the heading “L5”). Statistical significance were based on a FWE corrected p-value threshold of p < 0.05 and k = 5 voxel threshold.
Mentions: Finally, the same methodology was used to create contrast maps to observe the effects of multimodal stimulus presentation during session 2. From this, AA_MM2-AA2 was the only contrast map to show significance. As seen in Figure 10, it showed greater activity in the NT than ASD group for the right fusiform gyrus (BA 37R). This contrast consists of activation during the second presentation of a sequence of two multimodal stimuli minus the second presentation in a sequence of two audio stimuli. In this case the multimodal stimuli were surprise stimuli that were applied to only a small percentage of a larger stimulus block made of mostly sequences of two audio stimuli followed by another sequence of two audio stimuli.

Bottom Line: Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28.Analysis focused on EEG power, BOLD fMRI, and accuracy.Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical and Computer Engineering, Texas Tech University, Lubbock TX, USA.

ABSTRACT
Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28. We hypothesized that ASD performance on combined audiovisual trials would be less accurate with observable decreased EEG power across frontal, temporal, and occipital channels and decreased BOLD fMRI activity in these same regions; reflecting deficits in key sensory processing areas. Analysis focused on EEG power, BOLD fMRI, and accuracy. Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

No MeSH data available.


Related in: MedlinePlus