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Visual, Auditory, and Cross Modal Sensory Processing in Adults with Autism: An EEG Power and BOLD fMRI Investigation.

Hames EC, Murphy B, Rajmohan R, Anderson RC, Baker M, Zupancic S, O'Boyle M, Richman D - Front Hum Neurosci (2016)

Bottom Line: Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28.Analysis focused on EEG power, BOLD fMRI, and accuracy.Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical and Computer Engineering, Texas Tech University, Lubbock TX, USA.

ABSTRACT
Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28. We hypothesized that ASD performance on combined audiovisual trials would be less accurate with observable decreased EEG power across frontal, temporal, and occipital channels and decreased BOLD fMRI activity in these same regions; reflecting deficits in key sensory processing areas. Analysis focused on EEG power, BOLD fMRI, and accuracy. Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

No MeSH data available.


Related in: MedlinePlus

Session 1 AA2-VV2 Controls > ASD significant fMRI activations. Axial cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the axial planes (blue lines; top row). Coronal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the coronal planes (blue lines; middle row). Sagittal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A coronal cross section depicts the location of the sagittal planes (blue lines; bottom row). The corresponding Brodmann area for significant areas of activation is listed in the table at bottom (under the heading “L5”). Statistical significance were based on a FWE corrected p-value threshold of p < 0.05 and k = 5 voxel threshold.
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Figure 9: Session 1 AA2-VV2 Controls > ASD significant fMRI activations. Axial cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the axial planes (blue lines; top row). Coronal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the coronal planes (blue lines; middle row). Sagittal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A coronal cross section depicts the location of the sagittal planes (blue lines; bottom row). The corresponding Brodmann area for significant areas of activation is listed in the table at bottom (under the heading “L5”). Statistical significance were based on a FWE corrected p-value threshold of p < 0.05 and k = 5 voxel threshold.

Mentions: Next, we investigated how processing of repeated presentation of a unimodal stimulus may be affected by contrasting unimodal processing of auditory and visual stimuli trial conditions across the ASD and NT groups in Figure 9. In this contrast, the activations related to the second auditory stimulus in a sequence of two auditory stimuli were subtracted from the second visual stimulus in a sequence of two visual stimuli. Here we see that controls exhibited higher activation in unimodal processing of auditory information (AA2-VV2) with predictable increased activation of the left auditory cortex (BA 42L).


Visual, Auditory, and Cross Modal Sensory Processing in Adults with Autism: An EEG Power and BOLD fMRI Investigation.

Hames EC, Murphy B, Rajmohan R, Anderson RC, Baker M, Zupancic S, O'Boyle M, Richman D - Front Hum Neurosci (2016)

Session 1 AA2-VV2 Controls > ASD significant fMRI activations. Axial cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the axial planes (blue lines; top row). Coronal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the coronal planes (blue lines; middle row). Sagittal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A coronal cross section depicts the location of the sagittal planes (blue lines; bottom row). The corresponding Brodmann area for significant areas of activation is listed in the table at bottom (under the heading “L5”). Statistical significance were based on a FWE corrected p-value threshold of p < 0.05 and k = 5 voxel threshold.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835455&req=5

Figure 9: Session 1 AA2-VV2 Controls > ASD significant fMRI activations. Axial cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the axial planes (blue lines; top row). Coronal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A sagittal cross section depicts the location of the coronal planes (blue lines; middle row). Sagittal cross sections highlighting regions of greater Control (orange) group-level activations are depicted for four planes. A coronal cross section depicts the location of the sagittal planes (blue lines; bottom row). The corresponding Brodmann area for significant areas of activation is listed in the table at bottom (under the heading “L5”). Statistical significance were based on a FWE corrected p-value threshold of p < 0.05 and k = 5 voxel threshold.
Mentions: Next, we investigated how processing of repeated presentation of a unimodal stimulus may be affected by contrasting unimodal processing of auditory and visual stimuli trial conditions across the ASD and NT groups in Figure 9. In this contrast, the activations related to the second auditory stimulus in a sequence of two auditory stimuli were subtracted from the second visual stimulus in a sequence of two visual stimuli. Here we see that controls exhibited higher activation in unimodal processing of auditory information (AA2-VV2) with predictable increased activation of the left auditory cortex (BA 42L).

Bottom Line: Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28.Analysis focused on EEG power, BOLD fMRI, and accuracy.Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical and Computer Engineering, Texas Tech University, Lubbock TX, USA.

ABSTRACT
Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28. We hypothesized that ASD performance on combined audiovisual trials would be less accurate with observable decreased EEG power across frontal, temporal, and occipital channels and decreased BOLD fMRI activity in these same regions; reflecting deficits in key sensory processing areas. Analysis focused on EEG power, BOLD fMRI, and accuracy. Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

No MeSH data available.


Related in: MedlinePlus