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Visual, Auditory, and Cross Modal Sensory Processing in Adults with Autism: An EEG Power and BOLD fMRI Investigation.

Hames EC, Murphy B, Rajmohan R, Anderson RC, Baker M, Zupancic S, O'Boyle M, Richman D - Front Hum Neurosci (2016)

Bottom Line: Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28.Analysis focused on EEG power, BOLD fMRI, and accuracy.Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical and Computer Engineering, Texas Tech University, Lubbock TX, USA.

ABSTRACT
Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28. We hypothesized that ASD performance on combined audiovisual trials would be less accurate with observable decreased EEG power across frontal, temporal, and occipital channels and decreased BOLD fMRI activity in these same regions; reflecting deficits in key sensory processing areas. Analysis focused on EEG power, BOLD fMRI, and accuracy. Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

No MeSH data available.


Related in: MedlinePlus

Session 2 alpha and beta EEG power group differences-unimodal auditory presentations. Results for the alpha band (left) and beta band (right) are presented. Significant differences were determined using the Tukey–Kramer method for p < 0.05.
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Figure 6: Session 2 alpha and beta EEG power group differences-unimodal auditory presentations. Results for the alpha band (left) and beta band (right) are presented. Significant differences were determined using the Tukey–Kramer method for p < 0.05.

Mentions: The results for the average power of the alpha and beta band frequencies for the ASD vs. NT groups are summarized in Tables 4 and 5 as well as presented in Figures 5–7. Figures 5 and 6 report the average power EEG head plots for alpha and beta bands in unimodal visual presentations and unimodal auditory presentations, respectively. Figure 7 reports the average power for alpha and beta bands in mixed (simultaneous) presentation trials. Again, EEG average power was lower for the ASD group across all channels for all events (graphs of average EEG power). In this session, the unimodal presentations of auditory and visual stimuli (AA1, AA2, VV1, and VV2) were once again presented and were shown to elicit similar, although not entirely identical, EEG head plots compared to session 1. Plots of trials containing mixed (simultaneous) stimulus presentations were more similar to unimodal visual stimulus presentation and cross modal trials that were embedded in a visual block (VV_VA) than unimodal auditory or cross modal trials that were embedded in an auditory block (AA_VA). Differences in average power between the ASD and NT groups were consistently localized to reductions in both the alpha and beta bands in frontal areas (channel groups 1 and 13) for these trials; a profile which was consistent with the head plots observed during the presentation of unimodal visual stimuli in both sessions 1 and 2.


Visual, Auditory, and Cross Modal Sensory Processing in Adults with Autism: An EEG Power and BOLD fMRI Investigation.

Hames EC, Murphy B, Rajmohan R, Anderson RC, Baker M, Zupancic S, O'Boyle M, Richman D - Front Hum Neurosci (2016)

Session 2 alpha and beta EEG power group differences-unimodal auditory presentations. Results for the alpha band (left) and beta band (right) are presented. Significant differences were determined using the Tukey–Kramer method for p < 0.05.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835455&req=5

Figure 6: Session 2 alpha and beta EEG power group differences-unimodal auditory presentations. Results for the alpha band (left) and beta band (right) are presented. Significant differences were determined using the Tukey–Kramer method for p < 0.05.
Mentions: The results for the average power of the alpha and beta band frequencies for the ASD vs. NT groups are summarized in Tables 4 and 5 as well as presented in Figures 5–7. Figures 5 and 6 report the average power EEG head plots for alpha and beta bands in unimodal visual presentations and unimodal auditory presentations, respectively. Figure 7 reports the average power for alpha and beta bands in mixed (simultaneous) presentation trials. Again, EEG average power was lower for the ASD group across all channels for all events (graphs of average EEG power). In this session, the unimodal presentations of auditory and visual stimuli (AA1, AA2, VV1, and VV2) were once again presented and were shown to elicit similar, although not entirely identical, EEG head plots compared to session 1. Plots of trials containing mixed (simultaneous) stimulus presentations were more similar to unimodal visual stimulus presentation and cross modal trials that were embedded in a visual block (VV_VA) than unimodal auditory or cross modal trials that were embedded in an auditory block (AA_VA). Differences in average power between the ASD and NT groups were consistently localized to reductions in both the alpha and beta bands in frontal areas (channel groups 1 and 13) for these trials; a profile which was consistent with the head plots observed during the presentation of unimodal visual stimuli in both sessions 1 and 2.

Bottom Line: Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28.Analysis focused on EEG power, BOLD fMRI, and accuracy.Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical and Computer Engineering, Texas Tech University, Lubbock TX, USA.

ABSTRACT
Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28. We hypothesized that ASD performance on combined audiovisual trials would be less accurate with observable decreased EEG power across frontal, temporal, and occipital channels and decreased BOLD fMRI activity in these same regions; reflecting deficits in key sensory processing areas. Analysis focused on EEG power, BOLD fMRI, and accuracy. Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

No MeSH data available.


Related in: MedlinePlus