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Visual, Auditory, and Cross Modal Sensory Processing in Adults with Autism: An EEG Power and BOLD fMRI Investigation.

Hames EC, Murphy B, Rajmohan R, Anderson RC, Baker M, Zupancic S, O'Boyle M, Richman D - Front Hum Neurosci (2016)

Bottom Line: Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28.Analysis focused on EEG power, BOLD fMRI, and accuracy.Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical and Computer Engineering, Texas Tech University, Lubbock TX, USA.

ABSTRACT
Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28. We hypothesized that ASD performance on combined audiovisual trials would be less accurate with observable decreased EEG power across frontal, temporal, and occipital channels and decreased BOLD fMRI activity in these same regions; reflecting deficits in key sensory processing areas. Analysis focused on EEG power, BOLD fMRI, and accuracy. Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

No MeSH data available.


Related in: MedlinePlus

Diagram of electrode placement and channel grouping for data reduction purposes. Original 60 channels (top) and reduction to 14 channel groups (bottom).
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Figure 3: Diagram of electrode placement and channel grouping for data reduction purposes. Original 60 channels (top) and reduction to 14 channel groups (bottom).

Mentions: Electroencephalography RMS (root-mean-square) power was computed for each participant, for each EEG channel, and for each epoch within the alpha (8–12.6 Hz) and beta (13–30 Hz) frequency bands. The power computations were averaged within events for each participant. To reduce the amount of data, EEG channels were grouped into fourteen regions, shown in Figure 3. Participants’ channel power was averaged for each group of channels. After grouping channels, each participant had 2,268 power measures (14 channel regions × 3 frequency bands × 18 events × 3 epochs). Given that the presentation and processing of the stimuli would take approximately 1 s, the results presented in this section are computed using the “2nd second” epochs (i.e., 1 s after stimuli onset), with EEG power levels averaged across similar events, resulting in 14 power measures per frequency band per event type.


Visual, Auditory, and Cross Modal Sensory Processing in Adults with Autism: An EEG Power and BOLD fMRI Investigation.

Hames EC, Murphy B, Rajmohan R, Anderson RC, Baker M, Zupancic S, O'Boyle M, Richman D - Front Hum Neurosci (2016)

Diagram of electrode placement and channel grouping for data reduction purposes. Original 60 channels (top) and reduction to 14 channel groups (bottom).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835455&req=5

Figure 3: Diagram of electrode placement and channel grouping for data reduction purposes. Original 60 channels (top) and reduction to 14 channel groups (bottom).
Mentions: Electroencephalography RMS (root-mean-square) power was computed for each participant, for each EEG channel, and for each epoch within the alpha (8–12.6 Hz) and beta (13–30 Hz) frequency bands. The power computations were averaged within events for each participant. To reduce the amount of data, EEG channels were grouped into fourteen regions, shown in Figure 3. Participants’ channel power was averaged for each group of channels. After grouping channels, each participant had 2,268 power measures (14 channel regions × 3 frequency bands × 18 events × 3 epochs). Given that the presentation and processing of the stimuli would take approximately 1 s, the results presented in this section are computed using the “2nd second” epochs (i.e., 1 s after stimuli onset), with EEG power levels averaged across similar events, resulting in 14 power measures per frequency band per event type.

Bottom Line: Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28.Analysis focused on EEG power, BOLD fMRI, and accuracy.Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Electrical and Computer Engineering, Texas Tech University, Lubbock TX, USA.

ABSTRACT
Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20-28. We hypothesized that ASD performance on combined audiovisual trials would be less accurate with observable decreased EEG power across frontal, temporal, and occipital channels and decreased BOLD fMRI activity in these same regions; reflecting deficits in key sensory processing areas. Analysis focused on EEG power, BOLD fMRI, and accuracy. Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

No MeSH data available.


Related in: MedlinePlus