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Theoretical Analysis of Transcranial Magneto-Acoustical Stimulation with Hodgkin-Huxley Neuron Model.

Yuan Y, Chen Y, Li X - Front Comput Neurosci (2016)

Bottom Line: However, the effect of TMAS on the neuronal firing pattern remains unknown.The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound.The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound.

View Article: PubMed Central - PubMed

Affiliation: Department of Automation, Institute of Electrical Engineering, Yanshan University Qinhuangdao, China.

ABSTRACT
Transcranial magneto-acoustical stimulation (TMAS) is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities. As a key part of the neural network, neurons transmit information in the nervous system. However, the effect of TMAS on the neuronal firing pattern remains unknown. To address this problem, we investigated the stimulatory mechanism of TMAS on neurons, by using a Hodgkin-Huxley neuron model. The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound. The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound. This study may help to reveal and explain the biological mechanism of TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.

No MeSH data available.


(A–C) Waveforms of neuronal action potentials generated by TMAS under pulsed ultrasound with different RF, (A) 5 Hz, (B) 20 Hz, (C) 100 Hz. (D–F). The AMP, ISI, and FR of action potentials vs. RF, (D) AMP, (E) ISI, (F) FR.
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Figure 9: (A–C) Waveforms of neuronal action potentials generated by TMAS under pulsed ultrasound with different RF, (A) 5 Hz, (B) 20 Hz, (C) 100 Hz. (D–F). The AMP, ISI, and FR of action potentials vs. RF, (D) AMP, (E) ISI, (F) FR.

Mentions: Finally, we used RFs from 1 to 100 Hz to evaluate the effect of TMAS on the neuronal firing pattern under pulsed ultrasound. The magnetostatic field strength, ultrasound frequency, ultrasonic power and DC were 3 T, 500 kHz, 3 W/cm2, and 50%, respectively. The action potentials with repetition frequencies of 5, 20, and 100 Hz are shown in Figures 9A–C, respectively. The AMP, ISI, and FR of the action potential compared to repetition frequency are shown in Figures 9D–F, respectively. The results showed that both the AMP and ISI gradually decreased in a multilevel ladder shape route with an increase in repetition frequency. We also clearly observed that the FR significantly decreased as the RF increased from 1 to 100 Hz, after which the narrowing of the FR range was very limited.


Theoretical Analysis of Transcranial Magneto-Acoustical Stimulation with Hodgkin-Huxley Neuron Model.

Yuan Y, Chen Y, Li X - Front Comput Neurosci (2016)

(A–C) Waveforms of neuronal action potentials generated by TMAS under pulsed ultrasound with different RF, (A) 5 Hz, (B) 20 Hz, (C) 100 Hz. (D–F). The AMP, ISI, and FR of action potentials vs. RF, (D) AMP, (E) ISI, (F) FR.
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4835452&req=5

Figure 9: (A–C) Waveforms of neuronal action potentials generated by TMAS under pulsed ultrasound with different RF, (A) 5 Hz, (B) 20 Hz, (C) 100 Hz. (D–F). The AMP, ISI, and FR of action potentials vs. RF, (D) AMP, (E) ISI, (F) FR.
Mentions: Finally, we used RFs from 1 to 100 Hz to evaluate the effect of TMAS on the neuronal firing pattern under pulsed ultrasound. The magnetostatic field strength, ultrasound frequency, ultrasonic power and DC were 3 T, 500 kHz, 3 W/cm2, and 50%, respectively. The action potentials with repetition frequencies of 5, 20, and 100 Hz are shown in Figures 9A–C, respectively. The AMP, ISI, and FR of the action potential compared to repetition frequency are shown in Figures 9D–F, respectively. The results showed that both the AMP and ISI gradually decreased in a multilevel ladder shape route with an increase in repetition frequency. We also clearly observed that the FR significantly decreased as the RF increased from 1 to 100 Hz, after which the narrowing of the FR range was very limited.

Bottom Line: However, the effect of TMAS on the neuronal firing pattern remains unknown.The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound.The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound.

View Article: PubMed Central - PubMed

Affiliation: Department of Automation, Institute of Electrical Engineering, Yanshan University Qinhuangdao, China.

ABSTRACT
Transcranial magneto-acoustical stimulation (TMAS) is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities. As a key part of the neural network, neurons transmit information in the nervous system. However, the effect of TMAS on the neuronal firing pattern remains unknown. To address this problem, we investigated the stimulatory mechanism of TMAS on neurons, by using a Hodgkin-Huxley neuron model. The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound. The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound. This study may help to reveal and explain the biological mechanism of TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.

No MeSH data available.