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Theoretical Analysis of Transcranial Magneto-Acoustical Stimulation with Hodgkin-Huxley Neuron Model.

Yuan Y, Chen Y, Li X - Front Comput Neurosci (2016)

Bottom Line: However, the effect of TMAS on the neuronal firing pattern remains unknown.The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound.The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound.

View Article: PubMed Central - PubMed

Affiliation: Department of Automation, Institute of Electrical Engineering, Yanshan University Qinhuangdao, China.

ABSTRACT
Transcranial magneto-acoustical stimulation (TMAS) is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities. As a key part of the neural network, neurons transmit information in the nervous system. However, the effect of TMAS on the neuronal firing pattern remains unknown. To address this problem, we investigated the stimulatory mechanism of TMAS on neurons, by using a Hodgkin-Huxley neuron model. The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound. The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound. This study may help to reveal and explain the biological mechanism of TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.

No MeSH data available.


(A–C) Waveforms of neuronal action potentials generated by TMAS under pulsed ultrasound with different DC, (A) 5 %, (B) 50 %, (C) 95 %. (D–F). The AMP, ISI, and FR of action potentials vs. DC, (D) AMP, (E) ISI, (F) FR.
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Figure 8: (A–C) Waveforms of neuronal action potentials generated by TMAS under pulsed ultrasound with different DC, (A) 5 %, (B) 50 %, (C) 95 %. (D–F). The AMP, ISI, and FR of action potentials vs. DC, (D) AMP, (E) ISI, (F) FR.

Mentions: Next, DCs from 5 to 95% in intervals of 5% were selected to evaluate the effect of TMAS on the neuronal firing pattern under pulsed ultrasound. The values of the magnetostatic field strength, ultrasound frequency, ultrasonic power, and RF were 3 T, 500 kHz, 3 W/cm2, and 10 Hz, respectively. The action potentials with DCs of 5, 50, and 95% are shown in Figures 8A–C, respectively. The firing form of the neuron was also a cluster discharge. The time interval between the clusters decreased with the increase in repetition frequency. The AMP, ISI, and FR of the action potential in relation to the duty cycle are shown in Figures 8D–F, respectively. The results showed a weak decrease in the AMP and ISI with the increase in DC. We also found that the FR gradually decreased with the increase in DC.


Theoretical Analysis of Transcranial Magneto-Acoustical Stimulation with Hodgkin-Huxley Neuron Model.

Yuan Y, Chen Y, Li X - Front Comput Neurosci (2016)

(A–C) Waveforms of neuronal action potentials generated by TMAS under pulsed ultrasound with different DC, (A) 5 %, (B) 50 %, (C) 95 %. (D–F). The AMP, ISI, and FR of action potentials vs. DC, (D) AMP, (E) ISI, (F) FR.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835452&req=5

Figure 8: (A–C) Waveforms of neuronal action potentials generated by TMAS under pulsed ultrasound with different DC, (A) 5 %, (B) 50 %, (C) 95 %. (D–F). The AMP, ISI, and FR of action potentials vs. DC, (D) AMP, (E) ISI, (F) FR.
Mentions: Next, DCs from 5 to 95% in intervals of 5% were selected to evaluate the effect of TMAS on the neuronal firing pattern under pulsed ultrasound. The values of the magnetostatic field strength, ultrasound frequency, ultrasonic power, and RF were 3 T, 500 kHz, 3 W/cm2, and 10 Hz, respectively. The action potentials with DCs of 5, 50, and 95% are shown in Figures 8A–C, respectively. The firing form of the neuron was also a cluster discharge. The time interval between the clusters decreased with the increase in repetition frequency. The AMP, ISI, and FR of the action potential in relation to the duty cycle are shown in Figures 8D–F, respectively. The results showed a weak decrease in the AMP and ISI with the increase in DC. We also found that the FR gradually decreased with the increase in DC.

Bottom Line: However, the effect of TMAS on the neuronal firing pattern remains unknown.The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound.The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound.

View Article: PubMed Central - PubMed

Affiliation: Department of Automation, Institute of Electrical Engineering, Yanshan University Qinhuangdao, China.

ABSTRACT
Transcranial magneto-acoustical stimulation (TMAS) is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities. As a key part of the neural network, neurons transmit information in the nervous system. However, the effect of TMAS on the neuronal firing pattern remains unknown. To address this problem, we investigated the stimulatory mechanism of TMAS on neurons, by using a Hodgkin-Huxley neuron model. The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound. The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound. This study may help to reveal and explain the biological mechanism of TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.

No MeSH data available.