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Theoretical Analysis of Transcranial Magneto-Acoustical Stimulation with Hodgkin-Huxley Neuron Model.

Yuan Y, Chen Y, Li X - Front Comput Neurosci (2016)

Bottom Line: However, the effect of TMAS on the neuronal firing pattern remains unknown.The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound.The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound.

View Article: PubMed Central - PubMed

Affiliation: Department of Automation, Institute of Electrical Engineering, Yanshan University Qinhuangdao, China.

ABSTRACT
Transcranial magneto-acoustical stimulation (TMAS) is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities. As a key part of the neural network, neurons transmit information in the nervous system. However, the effect of TMAS on the neuronal firing pattern remains unknown. To address this problem, we investigated the stimulatory mechanism of TMAS on neurons, by using a Hodgkin-Huxley neuron model. The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound. The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound. This study may help to reveal and explain the biological mechanism of TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.

No MeSH data available.


(A–C) Waveforms of neuronal action potentials generated by TMAS under pulsed ultrasound with different ultrasound power, (A) 1 W/cm2, (B) 10 W/cm2, (C) 30 W/cm2, (D) 60 W/cm2, (E) 100 W/cm2. (F–H). The AMP, ISI and FR of action potentials vs. ultrasonic powers, (F) AMP, (G) ISI, (H) FR.
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Figure 7: (A–C) Waveforms of neuronal action potentials generated by TMAS under pulsed ultrasound with different ultrasound power, (A) 1 W/cm2, (B) 10 W/cm2, (C) 30 W/cm2, (D) 60 W/cm2, (E) 100 W/cm2. (F–H). The AMP, ISI and FR of action potentials vs. ultrasonic powers, (F) AMP, (G) ISI, (H) FR.

Mentions: First, to evaluate the effect of ultrasonic power on the firing pattern of neuronal action potential, the action potential was simulated under pulsed wave ultrasound with various ultrasonic powers. The values of the magnetostatic field strength, ultrasound frequency, duty cycle (DC), and repetition frequency (RF) were 3 T, 500 kHz, 50%, and 10 Hz, respectively. Figures 7A–E shows the waveforms of action potentials with ultrasonic powers of 1, 10, 30, 60, and 100 W/cm2, respectively. The neuronal firing form was a cluster discharge with the characteristics of a periodic variation and equal time intervals between the clusters. The number of pulses per cluster increased with the increase in ultrasonic power. The AMP, ISI, and FR of the action potential were quantitatively calculated, and the results are shown in Figures 7F–H. The results showed that the AMP significantly decreased with the increase in ultrasonic power. We also found that the ISI decreased with the increase in ultrasonic power from 1 to 100 W/cm2. The FR gradually increased in a multilevel ladder shape. The above results indicate that the firing pattern of neuronal action potential is selective for ultrasonic powers.


Theoretical Analysis of Transcranial Magneto-Acoustical Stimulation with Hodgkin-Huxley Neuron Model.

Yuan Y, Chen Y, Li X - Front Comput Neurosci (2016)

(A–C) Waveforms of neuronal action potentials generated by TMAS under pulsed ultrasound with different ultrasound power, (A) 1 W/cm2, (B) 10 W/cm2, (C) 30 W/cm2, (D) 60 W/cm2, (E) 100 W/cm2. (F–H). The AMP, ISI and FR of action potentials vs. ultrasonic powers, (F) AMP, (G) ISI, (H) FR.
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
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Figure 7: (A–C) Waveforms of neuronal action potentials generated by TMAS under pulsed ultrasound with different ultrasound power, (A) 1 W/cm2, (B) 10 W/cm2, (C) 30 W/cm2, (D) 60 W/cm2, (E) 100 W/cm2. (F–H). The AMP, ISI and FR of action potentials vs. ultrasonic powers, (F) AMP, (G) ISI, (H) FR.
Mentions: First, to evaluate the effect of ultrasonic power on the firing pattern of neuronal action potential, the action potential was simulated under pulsed wave ultrasound with various ultrasonic powers. The values of the magnetostatic field strength, ultrasound frequency, duty cycle (DC), and repetition frequency (RF) were 3 T, 500 kHz, 50%, and 10 Hz, respectively. Figures 7A–E shows the waveforms of action potentials with ultrasonic powers of 1, 10, 30, 60, and 100 W/cm2, respectively. The neuronal firing form was a cluster discharge with the characteristics of a periodic variation and equal time intervals between the clusters. The number of pulses per cluster increased with the increase in ultrasonic power. The AMP, ISI, and FR of the action potential were quantitatively calculated, and the results are shown in Figures 7F–H. The results showed that the AMP significantly decreased with the increase in ultrasonic power. We also found that the ISI decreased with the increase in ultrasonic power from 1 to 100 W/cm2. The FR gradually increased in a multilevel ladder shape. The above results indicate that the firing pattern of neuronal action potential is selective for ultrasonic powers.

Bottom Line: However, the effect of TMAS on the neuronal firing pattern remains unknown.The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound.The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound.

View Article: PubMed Central - PubMed

Affiliation: Department of Automation, Institute of Electrical Engineering, Yanshan University Qinhuangdao, China.

ABSTRACT
Transcranial magneto-acoustical stimulation (TMAS) is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities. As a key part of the neural network, neurons transmit information in the nervous system. However, the effect of TMAS on the neuronal firing pattern remains unknown. To address this problem, we investigated the stimulatory mechanism of TMAS on neurons, by using a Hodgkin-Huxley neuron model. The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound. The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound. This study may help to reveal and explain the biological mechanism of TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.

No MeSH data available.