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Theoretical Analysis of Transcranial Magneto-Acoustical Stimulation with Hodgkin-Huxley Neuron Model.

Yuan Y, Chen Y, Li X - Front Comput Neurosci (2016)

Bottom Line: However, the effect of TMAS on the neuronal firing pattern remains unknown.The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound.The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound.

View Article: PubMed Central - PubMed

Affiliation: Department of Automation, Institute of Electrical Engineering, Yanshan University Qinhuangdao, China.

ABSTRACT
Transcranial magneto-acoustical stimulation (TMAS) is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities. As a key part of the neural network, neurons transmit information in the nervous system. However, the effect of TMAS on the neuronal firing pattern remains unknown. To address this problem, we investigated the stimulatory mechanism of TMAS on neurons, by using a Hodgkin-Huxley neuron model. The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound. The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound. This study may help to reveal and explain the biological mechanism of TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.

No MeSH data available.


Two types of ultrasound and the related electric current. (A) Continuous wave ultrasound. (B) Pulsed ultrasound with the modulation of square wave and continuous wave.
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Figure 3: Two types of ultrasound and the related electric current. (A) Continuous wave ultrasound. (B) Pulsed ultrasound with the modulation of square wave and continuous wave.

Mentions: If the intensity of the magnetostatic field is constant, the current density of the nerve tissue is a function of the ultrasonic power, according to Equation (9). In this study, two types of ultrasound were used in the simulation. The first type, shown in Figure 3A, is continuous wave ultrasound, and the fundamental wave of ultrasound is a sine wave with offset (sin(2πft) + 1). The second type is pulsed ultrasound, with the modulation of a square wave and continuous wave (Figure 3B). It obeys the following Equation:(12)x(t)={1(n-1)1RF<t≤[(n-1)+DC]1RF,n=1,2,3…0 Otherswhere RF is the repetition frequency and DC is the duty cycle.


Theoretical Analysis of Transcranial Magneto-Acoustical Stimulation with Hodgkin-Huxley Neuron Model.

Yuan Y, Chen Y, Li X - Front Comput Neurosci (2016)

Two types of ultrasound and the related electric current. (A) Continuous wave ultrasound. (B) Pulsed ultrasound with the modulation of square wave and continuous wave.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835452&req=5

Figure 3: Two types of ultrasound and the related electric current. (A) Continuous wave ultrasound. (B) Pulsed ultrasound with the modulation of square wave and continuous wave.
Mentions: If the intensity of the magnetostatic field is constant, the current density of the nerve tissue is a function of the ultrasonic power, according to Equation (9). In this study, two types of ultrasound were used in the simulation. The first type, shown in Figure 3A, is continuous wave ultrasound, and the fundamental wave of ultrasound is a sine wave with offset (sin(2πft) + 1). The second type is pulsed ultrasound, with the modulation of a square wave and continuous wave (Figure 3B). It obeys the following Equation:(12)x(t)={1(n-1)1RF<t≤[(n-1)+DC]1RF,n=1,2,3…0 Otherswhere RF is the repetition frequency and DC is the duty cycle.

Bottom Line: However, the effect of TMAS on the neuronal firing pattern remains unknown.The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound.The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound.

View Article: PubMed Central - PubMed

Affiliation: Department of Automation, Institute of Electrical Engineering, Yanshan University Qinhuangdao, China.

ABSTRACT
Transcranial magneto-acoustical stimulation (TMAS) is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities. As a key part of the neural network, neurons transmit information in the nervous system. However, the effect of TMAS on the neuronal firing pattern remains unknown. To address this problem, we investigated the stimulatory mechanism of TMAS on neurons, by using a Hodgkin-Huxley neuron model. The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound. The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound. This study may help to reveal and explain the biological mechanism of TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.

No MeSH data available.