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Theoretical Analysis of Transcranial Magneto-Acoustical Stimulation with Hodgkin-Huxley Neuron Model.

Yuan Y, Chen Y, Li X - Front Comput Neurosci (2016)

Bottom Line: However, the effect of TMAS on the neuronal firing pattern remains unknown.The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound.The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound.

View Article: PubMed Central - PubMed

Affiliation: Department of Automation, Institute of Electrical Engineering, Yanshan University Qinhuangdao, China.

ABSTRACT
Transcranial magneto-acoustical stimulation (TMAS) is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities. As a key part of the neural network, neurons transmit information in the nervous system. However, the effect of TMAS on the neuronal firing pattern remains unknown. To address this problem, we investigated the stimulatory mechanism of TMAS on neurons, by using a Hodgkin-Huxley neuron model. The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound. The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound. This study may help to reveal and explain the biological mechanism of TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.

No MeSH data available.


(A) The fundamental wave of ultrasound with sine wave (top), the sodium current (center), the neuronal action potentials (bottom). (B) The fundamental wave of ultrasound with sine wave with offset (top), the sodium current (center), the neuronal action potentials (bottom).
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Figure 2: (A) The fundamental wave of ultrasound with sine wave (top), the sodium current (center), the neuronal action potentials (bottom). (B) The fundamental wave of ultrasound with sine wave with offset (top), the sodium current (center), the neuronal action potentials (bottom).

Mentions: We assumed that the fundamental wave of ultrasound is a cosine wave. The simulation results are shown in Figure 2. When ultrasound and the magnetic field are under the same intensity, we found that the stimulation cannot make the neurons generate sodium current and action potentials if the fundamental wave of ultrasound is a sine wave (sin(2πft)), (Figure 2A). If the fundamental wave of ultrasound is a sine wave with offset (sin(2πft) + 1), the neurons are able to generate sodium current and action potentials with stimulation (Figure 2B). According to Equation (9), if the fundamental wave of ultrasound is a cosine wave, the electric current changes with the cosine, the sodium channel opens and then closes in a very short period of time (), and there is not enough time to generate an action potential. If the fundamental wave of ultrasound is a sine wave with offset, there is no negative phase in the electric current, the sodium channel can be opened for a long period of time, and the action potential can be generated.


Theoretical Analysis of Transcranial Magneto-Acoustical Stimulation with Hodgkin-Huxley Neuron Model.

Yuan Y, Chen Y, Li X - Front Comput Neurosci (2016)

(A) The fundamental wave of ultrasound with sine wave (top), the sodium current (center), the neuronal action potentials (bottom). (B) The fundamental wave of ultrasound with sine wave with offset (top), the sodium current (center), the neuronal action potentials (bottom).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835452&req=5

Figure 2: (A) The fundamental wave of ultrasound with sine wave (top), the sodium current (center), the neuronal action potentials (bottom). (B) The fundamental wave of ultrasound with sine wave with offset (top), the sodium current (center), the neuronal action potentials (bottom).
Mentions: We assumed that the fundamental wave of ultrasound is a cosine wave. The simulation results are shown in Figure 2. When ultrasound and the magnetic field are under the same intensity, we found that the stimulation cannot make the neurons generate sodium current and action potentials if the fundamental wave of ultrasound is a sine wave (sin(2πft)), (Figure 2A). If the fundamental wave of ultrasound is a sine wave with offset (sin(2πft) + 1), the neurons are able to generate sodium current and action potentials with stimulation (Figure 2B). According to Equation (9), if the fundamental wave of ultrasound is a cosine wave, the electric current changes with the cosine, the sodium channel opens and then closes in a very short period of time (), and there is not enough time to generate an action potential. If the fundamental wave of ultrasound is a sine wave with offset, there is no negative phase in the electric current, the sodium channel can be opened for a long period of time, and the action potential can be generated.

Bottom Line: However, the effect of TMAS on the neuronal firing pattern remains unknown.The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound.The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound.

View Article: PubMed Central - PubMed

Affiliation: Department of Automation, Institute of Electrical Engineering, Yanshan University Qinhuangdao, China.

ABSTRACT
Transcranial magneto-acoustical stimulation (TMAS) is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities. As a key part of the neural network, neurons transmit information in the nervous system. However, the effect of TMAS on the neuronal firing pattern remains unknown. To address this problem, we investigated the stimulatory mechanism of TMAS on neurons, by using a Hodgkin-Huxley neuron model. The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound. The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound. This study may help to reveal and explain the biological mechanism of TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.

No MeSH data available.