Limits...
Theoretical Analysis of Transcranial Magneto-Acoustical Stimulation with Hodgkin-Huxley Neuron Model.

Yuan Y, Chen Y, Li X - Front Comput Neurosci (2016)

Bottom Line: However, the effect of TMAS on the neuronal firing pattern remains unknown.The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound.The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound.

View Article: PubMed Central - PubMed

Affiliation: Department of Automation, Institute of Electrical Engineering, Yanshan University Qinhuangdao, China.

ABSTRACT
Transcranial magneto-acoustical stimulation (TMAS) is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities. As a key part of the neural network, neurons transmit information in the nervous system. However, the effect of TMAS on the neuronal firing pattern remains unknown. To address this problem, we investigated the stimulatory mechanism of TMAS on neurons, by using a Hodgkin-Huxley neuron model. The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound. The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound. This study may help to reveal and explain the biological mechanism of TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.

No MeSH data available.


Related in: MedlinePlus

(A) The usual Cartensian co-ordinate axes, the pressure waves longitudinal and propagating along z axis, and the magetostatic field along x axis, the created electric current density along y axis. (B) The schematic of TMAS principle.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4835452&req=5

Figure 1: (A) The usual Cartensian co-ordinate axes, the pressure waves longitudinal and propagating along z axis, and the magetostatic field along x axis, the created electric current density along y axis. (B) The schematic of TMAS principle.

Mentions: In our study, standard Cartesian coordinate axes were used. We assumed that the pressure waves were longitudinal and propagated along the z axis and that the magnetostatic field was along the x axis, thereby placing the current density along the y axis (Figures 1A,B).


Theoretical Analysis of Transcranial Magneto-Acoustical Stimulation with Hodgkin-Huxley Neuron Model.

Yuan Y, Chen Y, Li X - Front Comput Neurosci (2016)

(A) The usual Cartensian co-ordinate axes, the pressure waves longitudinal and propagating along z axis, and the magetostatic field along x axis, the created electric current density along y axis. (B) The schematic of TMAS principle.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835452&req=5

Figure 1: (A) The usual Cartensian co-ordinate axes, the pressure waves longitudinal and propagating along z axis, and the magetostatic field along x axis, the created electric current density along y axis. (B) The schematic of TMAS principle.
Mentions: In our study, standard Cartesian coordinate axes were used. We assumed that the pressure waves were longitudinal and propagated along the z axis and that the magnetostatic field was along the x axis, thereby placing the current density along the y axis (Figures 1A,B).

Bottom Line: However, the effect of TMAS on the neuronal firing pattern remains unknown.The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound.The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound.

View Article: PubMed Central - PubMed

Affiliation: Department of Automation, Institute of Electrical Engineering, Yanshan University Qinhuangdao, China.

ABSTRACT
Transcranial magneto-acoustical stimulation (TMAS) is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities. As a key part of the neural network, neurons transmit information in the nervous system. However, the effect of TMAS on the neuronal firing pattern remains unknown. To address this problem, we investigated the stimulatory mechanism of TMAS on neurons, by using a Hodgkin-Huxley neuron model. The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound. The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound. This study may help to reveal and explain the biological mechanism of TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.

No MeSH data available.


Related in: MedlinePlus