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Understanding Suicidal Behavior: The Contribution of Recent Resting-State fMRI Techniques.

Serafini G, Pardini M, Pompili M, Girardi P, Amore M - Front Psychiatry (2016)

View Article: PubMed Central - PubMed

Affiliation: Section of Psychiatry, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, University of Genoa , Genoa , Italy.

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Suicidal behavior is a relevant and multifaceted public health issue and is commonly associated with a significant disability and psychosocial impairment... Indeed, task-based fMRI has been used to probe the neural substrates of specific cognitive and emotional intermediate phenotype of suicide, such as error monitoring and decision-making, but task-based fMRI is inherently limited by the need of active collaboration by the scanned subject as well as by the nature of the task during fMRI data acquisition. fMRI data can be also acquired while the subject is not performing any task – i.e., at rest (rsfMRI) – to evaluate which brain regions present same patterns of activation over time that are supposed to represent a valid surrogate marker of functional connectivity between different gray matter areas and over the whole brain... Moreover, rsfMRI allows to explore the resting-state brain networks, in particular, the default mode network (DMN), that have been reported to be altered in several psychopathological conditions and may be not easily investigated using the commonly available task-based fMRI... Aiming to investigate the neural correlates of suicide thoughts, fMRI during presentation of autobiographical memories in depressed patients who recently attempted suicide has been also carried out... Interestingly, Northoff and colleagues suggested that hopelessness and self-related processing were associated with higher resting-state neural activity in the DMN... Grimm and colleagues aimed to investigate whether self-related emotional judgment may induce reduced negative BOLD responses (NBRs) in DMN regions of depressed patients... Reduced NBRs in the anterior regions of the DMN associated with abnormally increased self-focus together with ruminations, self-blame, abnormal coupling of the self to negative emotions, and enhanced attention to the own self were found among depressed patients relative to healthy individuals... Figure 1 showed the potential of rsfMRI techniques to inform about vulnerability to suicidal behavior... We mainly focused on self-relatedness of negative stimuli that, according to Grimm and colleagues, are predominantly related to reduced NBRs in the anterior regions of the DMN and increased vulnerability to suicidal behavior, whereas we omitted to mention the role of motivational and consummatory anhedonia that are presumably associated with reward network dysfunctions [for more details about this topic, see the recent review of Lener and Iosifescu ]... Overall, rsfMRI studies suggest the potential to identify functional intermediate phenotypes that may provide interesting information about suicide risk identification... Moreover, existing rsfMRI studies usually include relatively small and clinically heterogeneous samples (e.g., predominantly suicidal young adults) that may have seriously limited their statistical power... Furthermore, subject motion during the scan may significantly influence rsfMRI findings, although several methods have been proposed including approaches to reduce the impact of motion artifacts... Studies may also lack detailed information regarding medication doses or the duration of treatment... In conclusion, elucidating the functional deficits associated with specific network disturbances may help to clarify the pathophysiological mechanisms underlying suicidal behavior and assist in identifying high-risk individuals in clinical practice.

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The relationship between fMRI abnormalities and vulnerability to suicidal behavior. Note: default mode network (DMN), negative blood oxygenation level-dependent responses (NBRs), resting-state functional magnetic resonance imaging (rsfMRI).
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Figure 1: The relationship between fMRI abnormalities and vulnerability to suicidal behavior. Note: default mode network (DMN), negative blood oxygenation level-dependent responses (NBRs), resting-state functional magnetic resonance imaging (rsfMRI).

Mentions: Figure 1 showed the potential of rsfMRI techniques to inform about vulnerability to suicidal behavior. We mainly focused on self-relatedness of negative stimuli that, according to Grimm and colleagues (17), are predominantly related to reduced NBRs in the anterior regions of the DMN and increased vulnerability to suicidal behavior, whereas we omitted to mention the role of motivational and consummatory anhedonia that are presumably associated with reward network dysfunctions [for more details about this topic, see the recent review of Lener and Iosifescu (20)].


Understanding Suicidal Behavior: The Contribution of Recent Resting-State fMRI Techniques.

Serafini G, Pardini M, Pompili M, Girardi P, Amore M - Front Psychiatry (2016)

The relationship between fMRI abnormalities and vulnerability to suicidal behavior. Note: default mode network (DMN), negative blood oxygenation level-dependent responses (NBRs), resting-state functional magnetic resonance imaging (rsfMRI).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835442&req=5

Figure 1: The relationship between fMRI abnormalities and vulnerability to suicidal behavior. Note: default mode network (DMN), negative blood oxygenation level-dependent responses (NBRs), resting-state functional magnetic resonance imaging (rsfMRI).
Mentions: Figure 1 showed the potential of rsfMRI techniques to inform about vulnerability to suicidal behavior. We mainly focused on self-relatedness of negative stimuli that, according to Grimm and colleagues (17), are predominantly related to reduced NBRs in the anterior regions of the DMN and increased vulnerability to suicidal behavior, whereas we omitted to mention the role of motivational and consummatory anhedonia that are presumably associated with reward network dysfunctions [for more details about this topic, see the recent review of Lener and Iosifescu (20)].

View Article: PubMed Central - PubMed

Affiliation: Section of Psychiatry, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, University of Genoa , Genoa , Italy.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Suicidal behavior is a relevant and multifaceted public health issue and is commonly associated with a significant disability and psychosocial impairment... Indeed, task-based fMRI has been used to probe the neural substrates of specific cognitive and emotional intermediate phenotype of suicide, such as error monitoring and decision-making, but task-based fMRI is inherently limited by the need of active collaboration by the scanned subject as well as by the nature of the task during fMRI data acquisition. fMRI data can be also acquired while the subject is not performing any task – i.e., at rest (rsfMRI) – to evaluate which brain regions present same patterns of activation over time that are supposed to represent a valid surrogate marker of functional connectivity between different gray matter areas and over the whole brain... Moreover, rsfMRI allows to explore the resting-state brain networks, in particular, the default mode network (DMN), that have been reported to be altered in several psychopathological conditions and may be not easily investigated using the commonly available task-based fMRI... Aiming to investigate the neural correlates of suicide thoughts, fMRI during presentation of autobiographical memories in depressed patients who recently attempted suicide has been also carried out... Interestingly, Northoff and colleagues suggested that hopelessness and self-related processing were associated with higher resting-state neural activity in the DMN... Grimm and colleagues aimed to investigate whether self-related emotional judgment may induce reduced negative BOLD responses (NBRs) in DMN regions of depressed patients... Reduced NBRs in the anterior regions of the DMN associated with abnormally increased self-focus together with ruminations, self-blame, abnormal coupling of the self to negative emotions, and enhanced attention to the own self were found among depressed patients relative to healthy individuals... Figure 1 showed the potential of rsfMRI techniques to inform about vulnerability to suicidal behavior... We mainly focused on self-relatedness of negative stimuli that, according to Grimm and colleagues, are predominantly related to reduced NBRs in the anterior regions of the DMN and increased vulnerability to suicidal behavior, whereas we omitted to mention the role of motivational and consummatory anhedonia that are presumably associated with reward network dysfunctions [for more details about this topic, see the recent review of Lener and Iosifescu ]... Overall, rsfMRI studies suggest the potential to identify functional intermediate phenotypes that may provide interesting information about suicide risk identification... Moreover, existing rsfMRI studies usually include relatively small and clinically heterogeneous samples (e.g., predominantly suicidal young adults) that may have seriously limited their statistical power... Furthermore, subject motion during the scan may significantly influence rsfMRI findings, although several methods have been proposed including approaches to reduce the impact of motion artifacts... Studies may also lack detailed information regarding medication doses or the duration of treatment... In conclusion, elucidating the functional deficits associated with specific network disturbances may help to clarify the pathophysiological mechanisms underlying suicidal behavior and assist in identifying high-risk individuals in clinical practice.

No MeSH data available.


Related in: MedlinePlus