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A Survey of Serum Bactericidal Antibodies against Neisseria meningitidis Serogroups A, C, W and Y in Adolescents and Adults in the Republic of Korea.

Kang JH, Miao Y, Lee S, Kim JH, Lee KY, Ma SH, Jo DS, Song H, Haag M - Infect Chemother (2016)

Bottom Line: Percentages of subjects with hSBA titres ≥4 and ≥8, geometric mean titres (GMTs), and associated 95% confidence intervals (CIs), were estimated.These trends were maintained across age groups and regions.The highest GMTs for serogroups A, W and Y were observed in the >19-29 years group.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

ABSTRACT

Background: This descriptive epidemiological study aimed to assess the prevalence of serum bactericidal antibodies against Neisseria meningitidis serogroups A, C, W and Y in adolescents and adults in the Republic of Korea.

Materials and methods: In total, 987 subjects aged 11-55 years from five geographical regions of Korea were included in the study. Human serum bactericidal assay (hSBA) was used to measure hSBA titres for serogroups A, C, W and Y. Percentages of subjects with hSBA titres ≥4 and ≥8, geometric mean titres (GMTs), and associated 95% confidence intervals (CIs), were estimated. Analysis was performed for the entire study population and stratified by age group or region. No statistical hypotheses were tested.

Results: The highest percentage of subjects with hSBA titres ≥8 was observed for serogroup W (74%), was similar for serogroups C (34%) and Y (36%), and was lowest for serogroup A (9%). The percentages of subjects with hSBA titres ≥4 were similar to those with hSBA titres ≥8 for all serogroups. GMTs were 2.56 µg/mL (serogroup A), 5.14 µg/mL (serogroup C), 22.63 µg/mL (serogroup W) and 5.28 µg/mL (serogroup Y). Similar trends in GMTs across serogroups were seen for individual regions and age groups. The highest GMTs for serogroups A, W and Y were recorded in the >19-29 years group, and for serogroup C in the >49-55 years group. Across all regions, GMTs were very similar for serogroups A, C and Y, while more variation was seen for serogroup W.

Conclusion: In the Korean population, among Neisseria meningitidis serogroups A, C, W and Y, serum bactericidal antibodies were most prevalent against serogroup W and least prevalent against serogroup A. These trends were maintained across age groups and regions. The highest GMTs for serogroups A, W and Y were observed in the >19-29 years group. The reasons behind the observed differences in prevalence of bactericidal antibodies against the serogroups are currently not understood, although carriage and cross-reactivity of the assay may be important influences.

No MeSH data available.


Percentage of subjects 11 to 55 years of age with human serum bactericidal assay (hSBA) titres ≥4, ≥8 and hSBA geometric mean titres (GMTs) for each of the serogroups, stratified by (A) age group and (B) region of Korea.
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Figure 1: Percentage of subjects 11 to 55 years of age with human serum bactericidal assay (hSBA) titres ≥4, ≥8 and hSBA geometric mean titres (GMTs) for each of the serogroups, stratified by (A) age group and (B) region of Korea.

Mentions: When stratified by age group, observed trends for the prevalence of bactericidal antibodies against serogroups A, C, W were similar to those seen for the entire population. There was some variation among age groups for individual serogroups (Fig. 1A); percentages of subjects with hSBA titres ≥4 and ≥8 and GMTs were highest for the >19-29 years age group, compared with other age groups, except for serogroup C, where the highest GMTs were observed for the >49-55 years group. Similarly, results by region showed the same trend as for the entire study population, although there were some small regional variations, with higher prevalence of bactericidal antibodies seen in the Jeolla-do region for serogroup W and the lowest prevalence for all serogroups seen in Seoul (Fig. 1B).


A Survey of Serum Bactericidal Antibodies against Neisseria meningitidis Serogroups A, C, W and Y in Adolescents and Adults in the Republic of Korea.

Kang JH, Miao Y, Lee S, Kim JH, Lee KY, Ma SH, Jo DS, Song H, Haag M - Infect Chemother (2016)

Percentage of subjects 11 to 55 years of age with human serum bactericidal assay (hSBA) titres ≥4, ≥8 and hSBA geometric mean titres (GMTs) for each of the serogroups, stratified by (A) age group and (B) region of Korea.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835430&req=5

Figure 1: Percentage of subjects 11 to 55 years of age with human serum bactericidal assay (hSBA) titres ≥4, ≥8 and hSBA geometric mean titres (GMTs) for each of the serogroups, stratified by (A) age group and (B) region of Korea.
Mentions: When stratified by age group, observed trends for the prevalence of bactericidal antibodies against serogroups A, C, W were similar to those seen for the entire population. There was some variation among age groups for individual serogroups (Fig. 1A); percentages of subjects with hSBA titres ≥4 and ≥8 and GMTs were highest for the >19-29 years age group, compared with other age groups, except for serogroup C, where the highest GMTs were observed for the >49-55 years group. Similarly, results by region showed the same trend as for the entire study population, although there were some small regional variations, with higher prevalence of bactericidal antibodies seen in the Jeolla-do region for serogroup W and the lowest prevalence for all serogroups seen in Seoul (Fig. 1B).

Bottom Line: Percentages of subjects with hSBA titres ≥4 and ≥8, geometric mean titres (GMTs), and associated 95% confidence intervals (CIs), were estimated.These trends were maintained across age groups and regions.The highest GMTs for serogroups A, W and Y were observed in the >19-29 years group.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

ABSTRACT

Background: This descriptive epidemiological study aimed to assess the prevalence of serum bactericidal antibodies against Neisseria meningitidis serogroups A, C, W and Y in adolescents and adults in the Republic of Korea.

Materials and methods: In total, 987 subjects aged 11-55 years from five geographical regions of Korea were included in the study. Human serum bactericidal assay (hSBA) was used to measure hSBA titres for serogroups A, C, W and Y. Percentages of subjects with hSBA titres ≥4 and ≥8, geometric mean titres (GMTs), and associated 95% confidence intervals (CIs), were estimated. Analysis was performed for the entire study population and stratified by age group or region. No statistical hypotheses were tested.

Results: The highest percentage of subjects with hSBA titres ≥8 was observed for serogroup W (74%), was similar for serogroups C (34%) and Y (36%), and was lowest for serogroup A (9%). The percentages of subjects with hSBA titres ≥4 were similar to those with hSBA titres ≥8 for all serogroups. GMTs were 2.56 µg/mL (serogroup A), 5.14 µg/mL (serogroup C), 22.63 µg/mL (serogroup W) and 5.28 µg/mL (serogroup Y). Similar trends in GMTs across serogroups were seen for individual regions and age groups. The highest GMTs for serogroups A, W and Y were recorded in the >19-29 years group, and for serogroup C in the >49-55 years group. Across all regions, GMTs were very similar for serogroups A, C and Y, while more variation was seen for serogroup W.

Conclusion: In the Korean population, among Neisseria meningitidis serogroups A, C, W and Y, serum bactericidal antibodies were most prevalent against serogroup W and least prevalent against serogroup A. These trends were maintained across age groups and regions. The highest GMTs for serogroups A, W and Y were observed in the >19-29 years group. The reasons behind the observed differences in prevalence of bactericidal antibodies against the serogroups are currently not understood, although carriage and cross-reactivity of the assay may be important influences.

No MeSH data available.