Limits...
The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy.

Zhao MX, Zhu BJ - Nanoscale Res Lett (2016)

Bottom Line: In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization.So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years.In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng, 475004, China. zhaomeixia2011@henu.edu.cn.

ABSTRACT
Quantum dots (QDs), nano-carriers for drugs, can help realize the targeting of drugs, and improve the bioavailability of drugs in biological fields. And, a QD nano-carrier system for drugs has the potential to realize early detection, monitoring, and localized treatments of specific disease sites. In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization. So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years. In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

No MeSH data available.


Related in: MedlinePlus

Schematic illustration of QD-aptamer (Dox) Bi-FRET system [43]
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4835414&req=5

Fig7: Schematic illustration of QD-aptamer (Dox) Bi-FRET system [43]

Mentions: In addition, the two-FRET system of QDs could release Dox in cells (Fig. 7) [43]. The identified prostate-specific membrane antigen A10 RNA aptamer were coated on the QD surface, and then they were mixed with Dox solution to make Dox inserted into the inner aptamer duplex to form QD-aptamer (Dox) complexes. The donor-acceptor consisting of Dox and QDs by cutting role and the donor-quenching body double FRET system consisting of Dox and aptamer resulted in reversible fluorescence self-quenching of complexes. With the extension of incubation time, and after the complexes are recognized and taken by prostate tumor cells, Dox is released from the complexes, and the fluorescence signals of QDs and Dox are significantly increased in cells. Both tumor cell localization and intracellular Dox release testing can be achieved by measuring the fluorescence signal changes.Fig. 7


The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy.

Zhao MX, Zhu BJ - Nanoscale Res Lett (2016)

Schematic illustration of QD-aptamer (Dox) Bi-FRET system [43]
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835414&req=5

Fig7: Schematic illustration of QD-aptamer (Dox) Bi-FRET system [43]
Mentions: In addition, the two-FRET system of QDs could release Dox in cells (Fig. 7) [43]. The identified prostate-specific membrane antigen A10 RNA aptamer were coated on the QD surface, and then they were mixed with Dox solution to make Dox inserted into the inner aptamer duplex to form QD-aptamer (Dox) complexes. The donor-acceptor consisting of Dox and QDs by cutting role and the donor-quenching body double FRET system consisting of Dox and aptamer resulted in reversible fluorescence self-quenching of complexes. With the extension of incubation time, and after the complexes are recognized and taken by prostate tumor cells, Dox is released from the complexes, and the fluorescence signals of QDs and Dox are significantly increased in cells. Both tumor cell localization and intracellular Dox release testing can be achieved by measuring the fluorescence signal changes.Fig. 7

Bottom Line: In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization.So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years.In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng, 475004, China. zhaomeixia2011@henu.edu.cn.

ABSTRACT
Quantum dots (QDs), nano-carriers for drugs, can help realize the targeting of drugs, and improve the bioavailability of drugs in biological fields. And, a QD nano-carrier system for drugs has the potential to realize early detection, monitoring, and localized treatments of specific disease sites. In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization. So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years. In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

No MeSH data available.


Related in: MedlinePlus