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The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy.

Zhao MX, Zhu BJ - Nanoscale Res Lett (2016)

Bottom Line: In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization.So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years.In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng, 475004, China. zhaomeixia2011@henu.edu.cn.

ABSTRACT
Quantum dots (QDs), nano-carriers for drugs, can help realize the targeting of drugs, and improve the bioavailability of drugs in biological fields. And, a QD nano-carrier system for drugs has the potential to realize early detection, monitoring, and localized treatments of specific disease sites. In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization. So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years. In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

No MeSH data available.


Related in: MedlinePlus

Schematic representation of cationic nanoparticles for targeted delivery of siRNA-aptamer chimeras [40]
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Fig6: Schematic representation of cationic nanoparticles for targeted delivery of siRNA-aptamer chimeras [40]

Mentions: SiRNA-aptamer chimeras are emerging as a highly promising approach for cell-type-specific delivery of siRNA due to the outstanding targeting capability of aptamers and the compatibility of chimeras with native ribonuclease (Dicer) processing [40]. For efficient RNAi, some challenges must be addressed, for example, how to get siRNA from the endosome after entering cells and how to retain aptamer targeting specificity when chimeras are combined with delivery carriers. Since both siRNA and aptamer are RNA molecules and often share similar molecular weight, so it is hard to design cationic delivery vehicles that selectively bind to the siRNA, leaving the targeting exposed aptamer. A rationally designed nano-particle carrier that simultaneously displays large surface area for high siRNA payload, exposed aptamer for specific targeting, proton sponge effect for endosome escape, and fluorescence for imaging and quantification were reported (Fig. 6) [40]. This method improved gene silencing efficiency over the conventional approaches based on simple mixing of siRNA-aptamer chimeras with cationic nanoparticles. This remarkable difference in RNAi efficiency using nano-particle-chimera complexes is directly related to cell uptake discrepancy resulting from aptamer conformation on nano-particle surface (intact vs. random).Fig. 6


The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy.

Zhao MX, Zhu BJ - Nanoscale Res Lett (2016)

Schematic representation of cationic nanoparticles for targeted delivery of siRNA-aptamer chimeras [40]
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835414&req=5

Fig6: Schematic representation of cationic nanoparticles for targeted delivery of siRNA-aptamer chimeras [40]
Mentions: SiRNA-aptamer chimeras are emerging as a highly promising approach for cell-type-specific delivery of siRNA due to the outstanding targeting capability of aptamers and the compatibility of chimeras with native ribonuclease (Dicer) processing [40]. For efficient RNAi, some challenges must be addressed, for example, how to get siRNA from the endosome after entering cells and how to retain aptamer targeting specificity when chimeras are combined with delivery carriers. Since both siRNA and aptamer are RNA molecules and often share similar molecular weight, so it is hard to design cationic delivery vehicles that selectively bind to the siRNA, leaving the targeting exposed aptamer. A rationally designed nano-particle carrier that simultaneously displays large surface area for high siRNA payload, exposed aptamer for specific targeting, proton sponge effect for endosome escape, and fluorescence for imaging and quantification were reported (Fig. 6) [40]. This method improved gene silencing efficiency over the conventional approaches based on simple mixing of siRNA-aptamer chimeras with cationic nanoparticles. This remarkable difference in RNAi efficiency using nano-particle-chimera complexes is directly related to cell uptake discrepancy resulting from aptamer conformation on nano-particle surface (intact vs. random).Fig. 6

Bottom Line: In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization.So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years.In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng, 475004, China. zhaomeixia2011@henu.edu.cn.

ABSTRACT
Quantum dots (QDs), nano-carriers for drugs, can help realize the targeting of drugs, and improve the bioavailability of drugs in biological fields. And, a QD nano-carrier system for drugs has the potential to realize early detection, monitoring, and localized treatments of specific disease sites. In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization. So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years. In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

No MeSH data available.


Related in: MedlinePlus