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The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy.

Zhao MX, Zhu BJ - Nanoscale Res Lett (2016)

Bottom Line: In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization.So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years.In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng, 475004, China. zhaomeixia2011@henu.edu.cn.

ABSTRACT
Quantum dots (QDs), nano-carriers for drugs, can help realize the targeting of drugs, and improve the bioavailability of drugs in biological fields. And, a QD nano-carrier system for drugs has the potential to realize early detection, monitoring, and localized treatments of specific disease sites. In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization. So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years. In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

No MeSH data available.


Related in: MedlinePlus

Schematic illustration of preparation steps of the Mn:ZnSe QD-based siRNA carriers [39]
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Fig5: Schematic illustration of preparation steps of the Mn:ZnSe QD-based siRNA carriers [39]

Mentions: The QD delivery systems are widely used to carry and image on siRNA in vivo and in vitro due to their inherent excellent optical properties. QDs are the ideal tool for discovering and validating in cells and small animals, but their potential uses in humans as drug delivery vehicles are unclear at present because bio-conjugated QDs cannot be efficiently cleared from the body either as intact particles or as ions [37, 38]. The large surface area of the amine-terminated nano-complex presents plenty of opportunities for further bio-functionalization while maintaining a high siRNA loading efficiency [37]. For example, the Mn:ZnSe d-dot can be used as a biocompatible nano-carrier for gene delivery in vitro (Fig. 5) [39]. Using a d-dot/polymer nano-complex as a transfection agent, siRNAs targeting the mutant oncogenic K-Ras gene were delivered into pancreatic cancer cells for sequence-specific gene therapy. The prepared nano-complex formulation achieved high gene transfection efficiency. Therapeutic effect was confirmed by the suppressed expression of the mutant K-Ras gene at the mRNA level. And, the d-dot/PAH nano-complex formulation is highly biocompatible even at a concentration as high as 160 μg mL−1, so the d-dots can act as a promising candidate for biomedical applications. And, the nano-complex can be functionalized with FA for receptor mediated cancer cell targeting and gene delivery.Fig. 5


The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy.

Zhao MX, Zhu BJ - Nanoscale Res Lett (2016)

Schematic illustration of preparation steps of the Mn:ZnSe QD-based siRNA carriers [39]
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835414&req=5

Fig5: Schematic illustration of preparation steps of the Mn:ZnSe QD-based siRNA carriers [39]
Mentions: The QD delivery systems are widely used to carry and image on siRNA in vivo and in vitro due to their inherent excellent optical properties. QDs are the ideal tool for discovering and validating in cells and small animals, but their potential uses in humans as drug delivery vehicles are unclear at present because bio-conjugated QDs cannot be efficiently cleared from the body either as intact particles or as ions [37, 38]. The large surface area of the amine-terminated nano-complex presents plenty of opportunities for further bio-functionalization while maintaining a high siRNA loading efficiency [37]. For example, the Mn:ZnSe d-dot can be used as a biocompatible nano-carrier for gene delivery in vitro (Fig. 5) [39]. Using a d-dot/polymer nano-complex as a transfection agent, siRNAs targeting the mutant oncogenic K-Ras gene were delivered into pancreatic cancer cells for sequence-specific gene therapy. The prepared nano-complex formulation achieved high gene transfection efficiency. Therapeutic effect was confirmed by the suppressed expression of the mutant K-Ras gene at the mRNA level. And, the d-dot/PAH nano-complex formulation is highly biocompatible even at a concentration as high as 160 μg mL−1, so the d-dots can act as a promising candidate for biomedical applications. And, the nano-complex can be functionalized with FA for receptor mediated cancer cell targeting and gene delivery.Fig. 5

Bottom Line: In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization.So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years.In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng, 475004, China. zhaomeixia2011@henu.edu.cn.

ABSTRACT
Quantum dots (QDs), nano-carriers for drugs, can help realize the targeting of drugs, and improve the bioavailability of drugs in biological fields. And, a QD nano-carrier system for drugs has the potential to realize early detection, monitoring, and localized treatments of specific disease sites. In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization. So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years. In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

No MeSH data available.


Related in: MedlinePlus