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The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy.

Zhao MX, Zhu BJ - Nanoscale Res Lett (2016)

Bottom Line: In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization.So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years.In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng, 475004, China. zhaomeixia2011@henu.edu.cn.

ABSTRACT
Quantum dots (QDs), nano-carriers for drugs, can help realize the targeting of drugs, and improve the bioavailability of drugs in biological fields. And, a QD nano-carrier system for drugs has the potential to realize early detection, monitoring, and localized treatments of specific disease sites. In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization. So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years. In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

No MeSH data available.


Related in: MedlinePlus

A scheme of folate-targeted DOX nano-aggregates with DOX-PEG-FOL conjugate, FOL folate [26]
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Fig4: A scheme of folate-targeted DOX nano-aggregates with DOX-PEG-FOL conjugate, FOL folate [26]

Mentions: Currently, as the tumor diagnosis materials, FA complexes have made some breakthroughs. For example some FA complexes coupled with radioactive elements (Fig. 4) have been used for clinical diagnosis of ovarian cancer [26]. But, the anti-tumor research about FA complexes in vivo was just the beginning. And, because FA complex structure and composition are complex, their metabolism and excretion in vivo, physiological function, stability, and toxicity are uncertain. In addition, some researchers consider that the release and treatment effects of drugs in FA complexes remain unsatisfactory in tumor tissues, so a lot of researches should be done before the FA complexes are used in clinical treatment of cancers. Along with widespread applications of QDs in biomedicine, more different fluorescent QDs made of FA complexes would be prepared for tumor diagnosis.Fig. 4


The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy.

Zhao MX, Zhu BJ - Nanoscale Res Lett (2016)

A scheme of folate-targeted DOX nano-aggregates with DOX-PEG-FOL conjugate, FOL folate [26]
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835414&req=5

Fig4: A scheme of folate-targeted DOX nano-aggregates with DOX-PEG-FOL conjugate, FOL folate [26]
Mentions: Currently, as the tumor diagnosis materials, FA complexes have made some breakthroughs. For example some FA complexes coupled with radioactive elements (Fig. 4) have been used for clinical diagnosis of ovarian cancer [26]. But, the anti-tumor research about FA complexes in vivo was just the beginning. And, because FA complex structure and composition are complex, their metabolism and excretion in vivo, physiological function, stability, and toxicity are uncertain. In addition, some researchers consider that the release and treatment effects of drugs in FA complexes remain unsatisfactory in tumor tissues, so a lot of researches should be done before the FA complexes are used in clinical treatment of cancers. Along with widespread applications of QDs in biomedicine, more different fluorescent QDs made of FA complexes would be prepared for tumor diagnosis.Fig. 4

Bottom Line: In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization.So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years.In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng, 475004, China. zhaomeixia2011@henu.edu.cn.

ABSTRACT
Quantum dots (QDs), nano-carriers for drugs, can help realize the targeting of drugs, and improve the bioavailability of drugs in biological fields. And, a QD nano-carrier system for drugs has the potential to realize early detection, monitoring, and localized treatments of specific disease sites. In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization. So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years. In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

No MeSH data available.


Related in: MedlinePlus