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The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy.

Zhao MX, Zhu BJ - Nanoscale Res Lett (2016)

Bottom Line: In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization.So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years.In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng, 475004, China. zhaomeixia2011@henu.edu.cn.

ABSTRACT
Quantum dots (QDs), nano-carriers for drugs, can help realize the targeting of drugs, and improve the bioavailability of drugs in biological fields. And, a QD nano-carrier system for drugs has the potential to realize early detection, monitoring, and localized treatments of specific disease sites. In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization. So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years. In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

No MeSH data available.


Related in: MedlinePlus

Schematic illustration of the preparative procedures of 1-NPs-QDs-FA [25]
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Fig3: Schematic illustration of the preparative procedures of 1-NPs-QDs-FA [25]

Mentions: FA, as a guiding molecule of anti-tumor drugs, has many advantages, such as low cost, high chemical stability, good receptor affinity, small size conducive to enter tumor cells through blood vessels, and completely infiltrate tumor tissues, etc., besides, FA complexes can well target to tumor cells. Now FA complexes have shown obvious advantages in targeting diagnosis and treatment on cancer. HSV-TK/GCV suicide gene systems are combined with near-infrared QDs, and the former is quite effective in liver cancer treatment, the latter facilitates tumor imaging [24]. A folate-modified theranostic (FL/QD-TK) was composed of an HSV-TK suicide gene covalently coupled with near-infrared fluorescent CdSeTe/ZnS core/shell QDs. FL/QD-TK exhibited highly specific tumor imaging and strong inhibition of the FR-over-expressed Bel-7402 mouse xenografts without systematic toxicity (Fig. 2) [24]. The facile surface-functionalization of one type of biocompatible, oligomeric nanoparticles 1-NPs binds with NIR-emitting CdTe/CdS QDs and folate could obtain tumor-targeted imaging in vivo (Fig. 3) [25]. As-prepared nanoparticles showed excellent targeting property to FR-expressing tumor cells in vitro and were successfully applied to selectively imaging FR over-expressing tumors in vivo.Fig. 2


The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy.

Zhao MX, Zhu BJ - Nanoscale Res Lett (2016)

Schematic illustration of the preparative procedures of 1-NPs-QDs-FA [25]
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835414&req=5

Fig3: Schematic illustration of the preparative procedures of 1-NPs-QDs-FA [25]
Mentions: FA, as a guiding molecule of anti-tumor drugs, has many advantages, such as low cost, high chemical stability, good receptor affinity, small size conducive to enter tumor cells through blood vessels, and completely infiltrate tumor tissues, etc., besides, FA complexes can well target to tumor cells. Now FA complexes have shown obvious advantages in targeting diagnosis and treatment on cancer. HSV-TK/GCV suicide gene systems are combined with near-infrared QDs, and the former is quite effective in liver cancer treatment, the latter facilitates tumor imaging [24]. A folate-modified theranostic (FL/QD-TK) was composed of an HSV-TK suicide gene covalently coupled with near-infrared fluorescent CdSeTe/ZnS core/shell QDs. FL/QD-TK exhibited highly specific tumor imaging and strong inhibition of the FR-over-expressed Bel-7402 mouse xenografts without systematic toxicity (Fig. 2) [24]. The facile surface-functionalization of one type of biocompatible, oligomeric nanoparticles 1-NPs binds with NIR-emitting CdTe/CdS QDs and folate could obtain tumor-targeted imaging in vivo (Fig. 3) [25]. As-prepared nanoparticles showed excellent targeting property to FR-expressing tumor cells in vitro and were successfully applied to selectively imaging FR over-expressing tumors in vivo.Fig. 2

Bottom Line: In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization.So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years.In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng, 475004, China. zhaomeixia2011@henu.edu.cn.

ABSTRACT
Quantum dots (QDs), nano-carriers for drugs, can help realize the targeting of drugs, and improve the bioavailability of drugs in biological fields. And, a QD nano-carrier system for drugs has the potential to realize early detection, monitoring, and localized treatments of specific disease sites. In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization. So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years. In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

No MeSH data available.


Related in: MedlinePlus