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The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy.

Zhao MX, Zhu BJ - Nanoscale Res Lett (2016)

Bottom Line: In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization.So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years.In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng, 475004, China. zhaomeixia2011@henu.edu.cn.

ABSTRACT
Quantum dots (QDs), nano-carriers for drugs, can help realize the targeting of drugs, and improve the bioavailability of drugs in biological fields. And, a QD nano-carrier system for drugs has the potential to realize early detection, monitoring, and localized treatments of specific disease sites. In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization. So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years. In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

No MeSH data available.


Related in: MedlinePlus

The scheme of folic acid
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Fig1: The scheme of folic acid

Mentions: Folate (folic acid, FA), which is a donor number of carbon unit in vivo, is a necessary material to biosynthesize nucleic acids, amino and pantothenic acid, and its structure is shown in Fig. 1. FA is a needed vitamin for everyone, and it not only can participate in a variety of metabolic pathways of one-carbon transfer reactions, but also is the targeting ligand of FR. With the development of molecular biology and molecular medicine and in-depth study of tumor molecular level, researchers have found a series of receptors associated with tumor growth on the surface of tumor cells or tumor-associated blood vessels, and found the receptors high affinity to combine with its ligands. Therefore, ligands as targeting molecules of drug carriers can enhance therapeutic efficacy via a receptor-mediating mechanism, and then to achieve targeted therapy. FR is highly expressed in most tumor cells (such as ovarian cancer, cervical cancer, endometrial cancer, breast cancer, colon cancer, lung cancer, nasopharyngeal carcinoma choroid, and ependymal cell tumor cells), so as a low molecular weight targeting molecule, FA quickly becomes a hot topic of research [20]. Studies have shown that FA complexes modified by carboxyl deuterogenic remained a strong binding capacity with FR [21]. Typically, protein toxins, small molecule chemotherapeutic agents, radio-therapeutic agents, polymer-wrapped drugs, gene carriers, pro-drug inhibitors, and immunotherapeutic agents can form multimeric complexes bound with FA by covalent coupling. These FA complexes have better targeting ability and more therapeutic effect than the original drug, so the FA complexes have higher potential for drug delivery system [22, 23].Fig. 1


The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy.

Zhao MX, Zhu BJ - Nanoscale Res Lett (2016)

The scheme of folic acid
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835414&req=5

Fig1: The scheme of folic acid
Mentions: Folate (folic acid, FA), which is a donor number of carbon unit in vivo, is a necessary material to biosynthesize nucleic acids, amino and pantothenic acid, and its structure is shown in Fig. 1. FA is a needed vitamin for everyone, and it not only can participate in a variety of metabolic pathways of one-carbon transfer reactions, but also is the targeting ligand of FR. With the development of molecular biology and molecular medicine and in-depth study of tumor molecular level, researchers have found a series of receptors associated with tumor growth on the surface of tumor cells or tumor-associated blood vessels, and found the receptors high affinity to combine with its ligands. Therefore, ligands as targeting molecules of drug carriers can enhance therapeutic efficacy via a receptor-mediating mechanism, and then to achieve targeted therapy. FR is highly expressed in most tumor cells (such as ovarian cancer, cervical cancer, endometrial cancer, breast cancer, colon cancer, lung cancer, nasopharyngeal carcinoma choroid, and ependymal cell tumor cells), so as a low molecular weight targeting molecule, FA quickly becomes a hot topic of research [20]. Studies have shown that FA complexes modified by carboxyl deuterogenic remained a strong binding capacity with FR [21]. Typically, protein toxins, small molecule chemotherapeutic agents, radio-therapeutic agents, polymer-wrapped drugs, gene carriers, pro-drug inhibitors, and immunotherapeutic agents can form multimeric complexes bound with FA by covalent coupling. These FA complexes have better targeting ability and more therapeutic effect than the original drug, so the FA complexes have higher potential for drug delivery system [22, 23].Fig. 1

Bottom Line: In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization.So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years.In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Natural Medicine and Immune Engineering, Henan University, Kaifeng, 475004, China. zhaomeixia2011@henu.edu.cn.

ABSTRACT
Quantum dots (QDs), nano-carriers for drugs, can help realize the targeting of drugs, and improve the bioavailability of drugs in biological fields. And, a QD nano-carrier system for drugs has the potential to realize early detection, monitoring, and localized treatments of specific disease sites. In addition, QD nano-carrier systems for drugs can improve stability of drugs, lengthen circulation time in vivo, enhance targeted absorption, and improve the distribution and metabolism process of drugs in organization. So, the development of QD nano-carriers for drugs has become a hotspot in the fields of nano-drug research in recent years. In this paper, we review the advantages and applications of the QD nano-carriers for drugs in biological fields.

No MeSH data available.


Related in: MedlinePlus