Limits...
Plasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the urotensin-2 gene are associated with migraines.

Geyik S, Ergun S, Kuzudişli S, Şensoy F, Temiz E, Altunışık E, Korkmaz M, Dağlı H, Kul S, Akçalı A, Neyal AM - J Headache Pain (2016)

Bottom Line: Plasma U-II levels were measured in attack free period.Plasma U-II levels were significantly higher in MWoA patients (p = 0.002).A significant relationship was found between U-II levels and MIDAS score (β = 0.508, p = 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. drsirmageyik@hotmail.com.

ABSTRACT

Background: Urotensin-II (U-II) is a peptide recognized by its potent vasoconstrictor activity in many vascular events, however the role of urotensin-II in migraine has not been considered yet. The molecular mechanisms and genetics of migraine have not been fully clarified yet, but it is well-known that vascular changes considerably contribute in pathophysiology of migraine and also its complications. The aim of this study was to analyze the plasma U-II levels along with genotype distributions and allele frequencies for UTS2 Thr21Met and Ser89Asn polymorphisms among the patients with migraine without aura (MWoA).

Methods: One hundred eighty-six patients with MWoA and 171 healthy individuals were included in this study. Plasma U-II levels were measured in attack free period. The genotype and allele frequencies for the Thr21Met (T21M) and Ser89Asn (S89N) polymorphisms in the UTS2 gene were analyzed.

Results: Plasma U-II levels were significantly higher in MWoA patients (p = 0.002). We detected a significant association between the T21M polymorphism in the UTS2 gene and migraine (53.8 % in patients, 40.4 % in controls, p = 0.035), but not with S89N polymorphism (p = 0.620). A significant relationship was found between U-II levels and MIDAS score (β = 0.508, p = 0.001).

Conclusion: Our study suggests that U-II may play a role in migraine pathogenesis; also Thr21Met polymorphism was associated with the risk of migraine disease. Further studies are needed for considering the role of U-II in migraine pathophysiology and for deciding if UTS2 gene may be a novel candidate gene in migraine cases.

No MeSH data available.


Related in: MedlinePlus

The correlation between U-II levels and MIDAS scores
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4835397&req=5

Fig2: The correlation between U-II levels and MIDAS scores

Mentions: The mean U-II levels were 1.19 ± 0.69 pg/ml in the migraine group and 0.97 ± 0.7 pg/ml in the control group. U-II plasma levels were significantly higher in the migraine group (p = 0.002) (Fig. 1). No differences in U-II levels were found in terms of gender, smoking status, symptomatic medication history in either group (Table 2). Disease duration and attack frequency were not significantly correlated with U-II levels (β:0.48/p:0.657, β: 0.195/p:0.175; respectively). A significant relationship was found between U-II levels and MIDAS score. U-II levels were significantly higher in patients with higher MIDAS scores. A 1 unit increase in the MIDAS score resulted in a 0.508 unit increase in U-II levels (β = 0.508, p = 0.001) (Fig. 2).Fig. 1


Plasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the urotensin-2 gene are associated with migraines.

Geyik S, Ergun S, Kuzudişli S, Şensoy F, Temiz E, Altunışık E, Korkmaz M, Dağlı H, Kul S, Akçalı A, Neyal AM - J Headache Pain (2016)

The correlation between U-II levels and MIDAS scores
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835397&req=5

Fig2: The correlation between U-II levels and MIDAS scores
Mentions: The mean U-II levels were 1.19 ± 0.69 pg/ml in the migraine group and 0.97 ± 0.7 pg/ml in the control group. U-II plasma levels were significantly higher in the migraine group (p = 0.002) (Fig. 1). No differences in U-II levels were found in terms of gender, smoking status, symptomatic medication history in either group (Table 2). Disease duration and attack frequency were not significantly correlated with U-II levels (β:0.48/p:0.657, β: 0.195/p:0.175; respectively). A significant relationship was found between U-II levels and MIDAS score. U-II levels were significantly higher in patients with higher MIDAS scores. A 1 unit increase in the MIDAS score resulted in a 0.508 unit increase in U-II levels (β = 0.508, p = 0.001) (Fig. 2).Fig. 1

Bottom Line: Plasma U-II levels were measured in attack free period.Plasma U-II levels were significantly higher in MWoA patients (p = 0.002).A significant relationship was found between U-II levels and MIDAS score (β = 0.508, p = 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. drsirmageyik@hotmail.com.

ABSTRACT

Background: Urotensin-II (U-II) is a peptide recognized by its potent vasoconstrictor activity in many vascular events, however the role of urotensin-II in migraine has not been considered yet. The molecular mechanisms and genetics of migraine have not been fully clarified yet, but it is well-known that vascular changes considerably contribute in pathophysiology of migraine and also its complications. The aim of this study was to analyze the plasma U-II levels along with genotype distributions and allele frequencies for UTS2 Thr21Met and Ser89Asn polymorphisms among the patients with migraine without aura (MWoA).

Methods: One hundred eighty-six patients with MWoA and 171 healthy individuals were included in this study. Plasma U-II levels were measured in attack free period. The genotype and allele frequencies for the Thr21Met (T21M) and Ser89Asn (S89N) polymorphisms in the UTS2 gene were analyzed.

Results: Plasma U-II levels were significantly higher in MWoA patients (p = 0.002). We detected a significant association between the T21M polymorphism in the UTS2 gene and migraine (53.8 % in patients, 40.4 % in controls, p = 0.035), but not with S89N polymorphism (p = 0.620). A significant relationship was found between U-II levels and MIDAS score (β = 0.508, p = 0.001).

Conclusion: Our study suggests that U-II may play a role in migraine pathogenesis; also Thr21Met polymorphism was associated with the risk of migraine disease. Further studies are needed for considering the role of U-II in migraine pathophysiology and for deciding if UTS2 gene may be a novel candidate gene in migraine cases.

No MeSH data available.


Related in: MedlinePlus