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Neurovestibular Compensation following Ototoxic Lesion and Labyrinthectomy.

Yazdanshenas H, Ashouri A, Kaufman G - Int Arch Otorhinolaryngol (2016)

Bottom Line: Results The gentamicin lesion resulted in a quicker recovery.Both groups displayed adaptation to the lesion by day 21, but long-term compensation did not completely revert to the original pre-lesion state.Static and dynamic compensations do not appear to be as independent as previous studies have suggested.

View Article: PubMed Central - PubMed

Affiliation: College of Medicine, UCLA & Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States.

ABSTRACT
Introduction Unilateral labyrinthectomy and intra-tympanic gentamycin have been employed in the treatment of Ménière's disease, but the efficacy of these techniques has not been well established. Objective The objective of this study is to measure the time course of recovery from a unilateral labyrinthectomy either after ipsilateral topical treatment with gentamicin to the inner ear or without the previous insult. Methods Twenty-nine adult Mongolian gerbils were randomized into two experimental groups. Group 1 (n = 17) received a right ear gentamicin drug-induced lesion by unilateral labyrinthectomy (UL). Group 2 (n = 12) only received a right unilateral labyrinthectomy lesion. We measured the horizontal vestibulo-ocular responses in gerbils before and after the lesion. The gerbils received an angular acceleration stimulus and their eye movements were recorded. Results The gentamicin lesion resulted in a quicker recovery. Experimental groups underwent a similar time course of recovery. Statistical analysis showed no significant difference between the two groups. Both groups displayed adaptation to the lesion by day 21, but long-term compensation did not completely revert to the original pre-lesion state. Conclusions In a lesion requiring both static and dynamic compensation as in UL, the need for a static compensation may alter pre-existing compensation from a previous dynamic insult and require a new compensation. A previous lesion and adaptation is not preserved for a second lesion and the subject has to re-compensate. Therefore, surgical treatment in Meniere's disease such as UL can be considered without prior gentamicin treatment. Static and dynamic compensations do not appear to be as independent as previous studies have suggested.

No MeSH data available.


Related in: MedlinePlus

VOR gain vs. time for gent, UL, and gent + UL groups at 0.5 Hz and 60° /sec (x-axis: logarithmic scale).
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FI0371or-5: VOR gain vs. time for gent, UL, and gent + UL groups at 0.5 Hz and 60° /sec (x-axis: logarithmic scale).

Mentions: After recovery from the gentamicin lesion (day 21), twelve gerbils underwent a second lesion (UL). This was done to indicate whether or not the prior compensation was beneficial for the second lesion compensation. The animals with the UL post-gentamicin lesion showed some bias velocity on day 1, as previously described (Fig. 2). Fig. 5 shows the Gentamicin, UL alone, Gent + UL animals at each half cycle for 0.5 Hz at 60°/sec velocity. The gentamicin compensation and gains were significantly above the gains for UL and Gent + UL groups. Data analysis showed no significant difference between the UL and Gent + UL groups at each time point (p ≥ 0.05).


Neurovestibular Compensation following Ototoxic Lesion and Labyrinthectomy.

Yazdanshenas H, Ashouri A, Kaufman G - Int Arch Otorhinolaryngol (2016)

VOR gain vs. time for gent, UL, and gent + UL groups at 0.5 Hz and 60° /sec (x-axis: logarithmic scale).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4835328&req=5

FI0371or-5: VOR gain vs. time for gent, UL, and gent + UL groups at 0.5 Hz and 60° /sec (x-axis: logarithmic scale).
Mentions: After recovery from the gentamicin lesion (day 21), twelve gerbils underwent a second lesion (UL). This was done to indicate whether or not the prior compensation was beneficial for the second lesion compensation. The animals with the UL post-gentamicin lesion showed some bias velocity on day 1, as previously described (Fig. 2). Fig. 5 shows the Gentamicin, UL alone, Gent + UL animals at each half cycle for 0.5 Hz at 60°/sec velocity. The gentamicin compensation and gains were significantly above the gains for UL and Gent + UL groups. Data analysis showed no significant difference between the UL and Gent + UL groups at each time point (p ≥ 0.05).

Bottom Line: Results The gentamicin lesion resulted in a quicker recovery.Both groups displayed adaptation to the lesion by day 21, but long-term compensation did not completely revert to the original pre-lesion state.Static and dynamic compensations do not appear to be as independent as previous studies have suggested.

View Article: PubMed Central - PubMed

Affiliation: College of Medicine, UCLA & Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States.

ABSTRACT
Introduction Unilateral labyrinthectomy and intra-tympanic gentamycin have been employed in the treatment of Ménière's disease, but the efficacy of these techniques has not been well established. Objective The objective of this study is to measure the time course of recovery from a unilateral labyrinthectomy either after ipsilateral topical treatment with gentamicin to the inner ear or without the previous insult. Methods Twenty-nine adult Mongolian gerbils were randomized into two experimental groups. Group 1 (n = 17) received a right ear gentamicin drug-induced lesion by unilateral labyrinthectomy (UL). Group 2 (n = 12) only received a right unilateral labyrinthectomy lesion. We measured the horizontal vestibulo-ocular responses in gerbils before and after the lesion. The gerbils received an angular acceleration stimulus and their eye movements were recorded. Results The gentamicin lesion resulted in a quicker recovery. Experimental groups underwent a similar time course of recovery. Statistical analysis showed no significant difference between the two groups. Both groups displayed adaptation to the lesion by day 21, but long-term compensation did not completely revert to the original pre-lesion state. Conclusions In a lesion requiring both static and dynamic compensation as in UL, the need for a static compensation may alter pre-existing compensation from a previous dynamic insult and require a new compensation. A previous lesion and adaptation is not preserved for a second lesion and the subject has to re-compensate. Therefore, surgical treatment in Meniere's disease such as UL can be considered without prior gentamicin treatment. Static and dynamic compensations do not appear to be as independent as previous studies have suggested.

No MeSH data available.


Related in: MedlinePlus