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The Neural Correlates of Chronic Symptoms of Vertigo Proneness in Humans.

Alsalman O, Ost J, Vanspauwen R, Blaivie C, De Ridder D, Vanneste S - PLoS ONE (2016)

Bottom Line: Vestibular signals are of significant importance for variable functions including gaze stabilization, spatial perception, navigation, cognition, and bodily self-consciousness.A region of interest analysis found reduced functional connectivity for gamma activity within the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex.This suggests that these patients have a neural signature or trait that makes them prone to developing chronic balance problems.

View Article: PubMed Central - PubMed

Affiliation: Lab for Clinical & Integrative Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, United States of America.

ABSTRACT
Vestibular signals are of significant importance for variable functions including gaze stabilization, spatial perception, navigation, cognition, and bodily self-consciousness. The vestibular network governs functions that might be impaired in patients affected with vestibular dysfunction. It is currently unclear how different brain regions/networks process vestibular information and integrate the information into a unified spatial percept related to somatosensory awareness and whether people with recurrent balance complaints have a neural signature as a trait affecting their development of chronic symptoms of vertigo. Pivotal evidence points to a vestibular-related brain network in humans that is widely distributed in nature. By using resting state source localized electroencephalography in non-vertiginous state, electrophysiological changes in activity and functional connectivity of 23 patients with balance complaints where chronic symptoms of vertigo and dizziness are among the most common reported complaints are analyzed and compared to healthy subjects. The analyses showed increased alpha2 activity within the posterior cingulate cortex and the precuneues/cuneus and reduced beta3 and gamma activity within the pregenual and subgenual anterior cingulate cortex for the subjects with balance complaints. These electrophysiological variations were correlated with reported chronic symptoms of vertigo intensity. A region of interest analysis found reduced functional connectivity for gamma activity within the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex. In addition, there was a positive correlation between chronic symptoms of vertigo intensity and increased alpha-gamma nesting in the left frontal eye field. When compared to healthy subjects, there is evidence of electrophysiological changes in the brain of patients with balance complaints even outside chronic symptoms of vertigo episodes. This suggests that these patients have a neural signature or trait that makes them prone to developing chronic balance problems.

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Related in: MedlinePlus

Functional connectivity analysis.Functional connectivity as measured by lagged phase synchronization for the gamma frequency band. (A) A decreased lagged phase synchronization is found for gamma between the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex. (B). Schematic representation of the interactions and connections between the different region of interests.
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pone.0152309.g004: Functional connectivity analysis.Functional connectivity as measured by lagged phase synchronization for the gamma frequency band. (A) A decreased lagged phase synchronization is found for gamma between the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex. (B). Schematic representation of the interactions and connections between the different region of interests.

Mentions: A comparison between patients with chronic symptoms of vertigo and healthy subjects for the functional connectivity analysis (lagged phase synchronization) yielded a significant difference (p < .05) for the gamma frequency band (Fig 4A & 4B). In general, reduced lagged phase coherence could be found for gamma band activity in the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex.


The Neural Correlates of Chronic Symptoms of Vertigo Proneness in Humans.

Alsalman O, Ost J, Vanspauwen R, Blaivie C, De Ridder D, Vanneste S - PLoS ONE (2016)

Functional connectivity analysis.Functional connectivity as measured by lagged phase synchronization for the gamma frequency band. (A) A decreased lagged phase synchronization is found for gamma between the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex. (B). Schematic representation of the interactions and connections between the different region of interests.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835222&req=5

pone.0152309.g004: Functional connectivity analysis.Functional connectivity as measured by lagged phase synchronization for the gamma frequency band. (A) A decreased lagged phase synchronization is found for gamma between the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex. (B). Schematic representation of the interactions and connections between the different region of interests.
Mentions: A comparison between patients with chronic symptoms of vertigo and healthy subjects for the functional connectivity analysis (lagged phase synchronization) yielded a significant difference (p < .05) for the gamma frequency band (Fig 4A & 4B). In general, reduced lagged phase coherence could be found for gamma band activity in the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex.

Bottom Line: Vestibular signals are of significant importance for variable functions including gaze stabilization, spatial perception, navigation, cognition, and bodily self-consciousness.A region of interest analysis found reduced functional connectivity for gamma activity within the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex.This suggests that these patients have a neural signature or trait that makes them prone to developing chronic balance problems.

View Article: PubMed Central - PubMed

Affiliation: Lab for Clinical & Integrative Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, United States of America.

ABSTRACT
Vestibular signals are of significant importance for variable functions including gaze stabilization, spatial perception, navigation, cognition, and bodily self-consciousness. The vestibular network governs functions that might be impaired in patients affected with vestibular dysfunction. It is currently unclear how different brain regions/networks process vestibular information and integrate the information into a unified spatial percept related to somatosensory awareness and whether people with recurrent balance complaints have a neural signature as a trait affecting their development of chronic symptoms of vertigo. Pivotal evidence points to a vestibular-related brain network in humans that is widely distributed in nature. By using resting state source localized electroencephalography in non-vertiginous state, electrophysiological changes in activity and functional connectivity of 23 patients with balance complaints where chronic symptoms of vertigo and dizziness are among the most common reported complaints are analyzed and compared to healthy subjects. The analyses showed increased alpha2 activity within the posterior cingulate cortex and the precuneues/cuneus and reduced beta3 and gamma activity within the pregenual and subgenual anterior cingulate cortex for the subjects with balance complaints. These electrophysiological variations were correlated with reported chronic symptoms of vertigo intensity. A region of interest analysis found reduced functional connectivity for gamma activity within the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex. In addition, there was a positive correlation between chronic symptoms of vertigo intensity and increased alpha-gamma nesting in the left frontal eye field. When compared to healthy subjects, there is evidence of electrophysiological changes in the brain of patients with balance complaints even outside chronic symptoms of vertigo episodes. This suggests that these patients have a neural signature or trait that makes them prone to developing chronic balance problems.

Show MeSH
Related in: MedlinePlus