Limits...
The Neural Correlates of Chronic Symptoms of Vertigo Proneness in Humans.

Alsalman O, Ost J, Vanspauwen R, Blaivie C, De Ridder D, Vanneste S - PLoS ONE (2016)

Bottom Line: Vestibular signals are of significant importance for variable functions including gaze stabilization, spatial perception, navigation, cognition, and bodily self-consciousness.A region of interest analysis found reduced functional connectivity for gamma activity within the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex.This suggests that these patients have a neural signature or trait that makes them prone to developing chronic balance problems.

View Article: PubMed Central - PubMed

Affiliation: Lab for Clinical & Integrative Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, United States of America.

ABSTRACT
Vestibular signals are of significant importance for variable functions including gaze stabilization, spatial perception, navigation, cognition, and bodily self-consciousness. The vestibular network governs functions that might be impaired in patients affected with vestibular dysfunction. It is currently unclear how different brain regions/networks process vestibular information and integrate the information into a unified spatial percept related to somatosensory awareness and whether people with recurrent balance complaints have a neural signature as a trait affecting their development of chronic symptoms of vertigo. Pivotal evidence points to a vestibular-related brain network in humans that is widely distributed in nature. By using resting state source localized electroencephalography in non-vertiginous state, electrophysiological changes in activity and functional connectivity of 23 patients with balance complaints where chronic symptoms of vertigo and dizziness are among the most common reported complaints are analyzed and compared to healthy subjects. The analyses showed increased alpha2 activity within the posterior cingulate cortex and the precuneues/cuneus and reduced beta3 and gamma activity within the pregenual and subgenual anterior cingulate cortex for the subjects with balance complaints. These electrophysiological variations were correlated with reported chronic symptoms of vertigo intensity. A region of interest analysis found reduced functional connectivity for gamma activity within the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex. In addition, there was a positive correlation between chronic symptoms of vertigo intensity and increased alpha-gamma nesting in the left frontal eye field. When compared to healthy subjects, there is evidence of electrophysiological changes in the brain of patients with balance complaints even outside chronic symptoms of vertigo episodes. This suggests that these patients have a neural signature or trait that makes them prone to developing chronic balance problems.

Show MeSH

Related in: MedlinePlus

Region of interest (ROI) analysis.A one-way MANOVA analysis of variance showed a significant difference for the left and right frontal eye field (p = .007, p = .005), left and right precuneus (p = .00, p = .003), left and right orbitofrontal cortex (p = .004, p = .009), and the left and right dorsal anterior cingulate cortex (p < .001). The left and right vestibular cortex, as well as the left and right intra-parietal sulcus yielded no significant effects. Error bars designate standard errors, and a * indicate a significant difference.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4835222&req=5

pone.0152309.g003: Region of interest (ROI) analysis.A one-way MANOVA analysis of variance showed a significant difference for the left and right frontal eye field (p = .007, p = .005), left and right precuneus (p = .00, p = .003), left and right orbitofrontal cortex (p = .004, p = .009), and the left and right dorsal anterior cingulate cortex (p < .001). The left and right vestibular cortex, as well as the left and right intra-parietal sulcus yielded no significant effects. Error bars designate standard errors, and a * indicate a significant difference.

Mentions: A one-way MANOVA analysis of variance was conducted for each of the eight frequency bands separately. Results from MANOVA demonstrated a significant effect for the gamma frequency band and the left frontal eye field (F = 7.93, p = .007), right frontal eye field (F = 8.64, p = .005), left precuneus (F = 13.90, p = .001), right precuneus (F = 9.56, p = .003), left orbitofrontal cortex (F = 9.26, p = .004), right orbitofrontal cortex (F = 7.38, p = .009), left dorsal anterior cingulate cortex (F = 17.11, p < .001), and the right dorsal anterior cingulate cortex (F = 16.12, p < .001). No significant effect was obtained between gamma and the left vestibular cortex (F = .26, p = .61), right vestibular cortex (F = .47, p = .54), left intrapartiel sulcus (F = .00013, p = .97), or right intrapartiel sulcus (F = .01, p = .92). See Fig 3 of log-transformed current density for gamma frequency band activity with the different regions of interest. No significant differences were obtained for the delta, theta, alpha1, alpha2 beta1, beta2, and beta3 frequency bands.


The Neural Correlates of Chronic Symptoms of Vertigo Proneness in Humans.

Alsalman O, Ost J, Vanspauwen R, Blaivie C, De Ridder D, Vanneste S - PLoS ONE (2016)

Region of interest (ROI) analysis.A one-way MANOVA analysis of variance showed a significant difference for the left and right frontal eye field (p = .007, p = .005), left and right precuneus (p = .00, p = .003), left and right orbitofrontal cortex (p = .004, p = .009), and the left and right dorsal anterior cingulate cortex (p < .001). The left and right vestibular cortex, as well as the left and right intra-parietal sulcus yielded no significant effects. Error bars designate standard errors, and a * indicate a significant difference.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835222&req=5

pone.0152309.g003: Region of interest (ROI) analysis.A one-way MANOVA analysis of variance showed a significant difference for the left and right frontal eye field (p = .007, p = .005), left and right precuneus (p = .00, p = .003), left and right orbitofrontal cortex (p = .004, p = .009), and the left and right dorsal anterior cingulate cortex (p < .001). The left and right vestibular cortex, as well as the left and right intra-parietal sulcus yielded no significant effects. Error bars designate standard errors, and a * indicate a significant difference.
Mentions: A one-way MANOVA analysis of variance was conducted for each of the eight frequency bands separately. Results from MANOVA demonstrated a significant effect for the gamma frequency band and the left frontal eye field (F = 7.93, p = .007), right frontal eye field (F = 8.64, p = .005), left precuneus (F = 13.90, p = .001), right precuneus (F = 9.56, p = .003), left orbitofrontal cortex (F = 9.26, p = .004), right orbitofrontal cortex (F = 7.38, p = .009), left dorsal anterior cingulate cortex (F = 17.11, p < .001), and the right dorsal anterior cingulate cortex (F = 16.12, p < .001). No significant effect was obtained between gamma and the left vestibular cortex (F = .26, p = .61), right vestibular cortex (F = .47, p = .54), left intrapartiel sulcus (F = .00013, p = .97), or right intrapartiel sulcus (F = .01, p = .92). See Fig 3 of log-transformed current density for gamma frequency band activity with the different regions of interest. No significant differences were obtained for the delta, theta, alpha1, alpha2 beta1, beta2, and beta3 frequency bands.

Bottom Line: Vestibular signals are of significant importance for variable functions including gaze stabilization, spatial perception, navigation, cognition, and bodily self-consciousness.A region of interest analysis found reduced functional connectivity for gamma activity within the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex.This suggests that these patients have a neural signature or trait that makes them prone to developing chronic balance problems.

View Article: PubMed Central - PubMed

Affiliation: Lab for Clinical & Integrative Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, United States of America.

ABSTRACT
Vestibular signals are of significant importance for variable functions including gaze stabilization, spatial perception, navigation, cognition, and bodily self-consciousness. The vestibular network governs functions that might be impaired in patients affected with vestibular dysfunction. It is currently unclear how different brain regions/networks process vestibular information and integrate the information into a unified spatial percept related to somatosensory awareness and whether people with recurrent balance complaints have a neural signature as a trait affecting their development of chronic symptoms of vertigo. Pivotal evidence points to a vestibular-related brain network in humans that is widely distributed in nature. By using resting state source localized electroencephalography in non-vertiginous state, electrophysiological changes in activity and functional connectivity of 23 patients with balance complaints where chronic symptoms of vertigo and dizziness are among the most common reported complaints are analyzed and compared to healthy subjects. The analyses showed increased alpha2 activity within the posterior cingulate cortex and the precuneues/cuneus and reduced beta3 and gamma activity within the pregenual and subgenual anterior cingulate cortex for the subjects with balance complaints. These electrophysiological variations were correlated with reported chronic symptoms of vertigo intensity. A region of interest analysis found reduced functional connectivity for gamma activity within the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex. In addition, there was a positive correlation between chronic symptoms of vertigo intensity and increased alpha-gamma nesting in the left frontal eye field. When compared to healthy subjects, there is evidence of electrophysiological changes in the brain of patients with balance complaints even outside chronic symptoms of vertigo episodes. This suggests that these patients have a neural signature or trait that makes them prone to developing chronic balance problems.

Show MeSH
Related in: MedlinePlus