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The Neural Correlates of Chronic Symptoms of Vertigo Proneness in Humans.

Alsalman O, Ost J, Vanspauwen R, Blaivie C, De Ridder D, Vanneste S - PLoS ONE (2016)

Bottom Line: Vestibular signals are of significant importance for variable functions including gaze stabilization, spatial perception, navigation, cognition, and bodily self-consciousness.A region of interest analysis found reduced functional connectivity for gamma activity within the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex.This suggests that these patients have a neural signature or trait that makes them prone to developing chronic balance problems.

View Article: PubMed Central - PubMed

Affiliation: Lab for Clinical & Integrative Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, United States of America.

ABSTRACT
Vestibular signals are of significant importance for variable functions including gaze stabilization, spatial perception, navigation, cognition, and bodily self-consciousness. The vestibular network governs functions that might be impaired in patients affected with vestibular dysfunction. It is currently unclear how different brain regions/networks process vestibular information and integrate the information into a unified spatial percept related to somatosensory awareness and whether people with recurrent balance complaints have a neural signature as a trait affecting their development of chronic symptoms of vertigo. Pivotal evidence points to a vestibular-related brain network in humans that is widely distributed in nature. By using resting state source localized electroencephalography in non-vertiginous state, electrophysiological changes in activity and functional connectivity of 23 patients with balance complaints where chronic symptoms of vertigo and dizziness are among the most common reported complaints are analyzed and compared to healthy subjects. The analyses showed increased alpha2 activity within the posterior cingulate cortex and the precuneues/cuneus and reduced beta3 and gamma activity within the pregenual and subgenual anterior cingulate cortex for the subjects with balance complaints. These electrophysiological variations were correlated with reported chronic symptoms of vertigo intensity. A region of interest analysis found reduced functional connectivity for gamma activity within the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex. In addition, there was a positive correlation between chronic symptoms of vertigo intensity and increased alpha-gamma nesting in the left frontal eye field. When compared to healthy subjects, there is evidence of electrophysiological changes in the brain of patients with balance complaints even outside chronic symptoms of vertigo episodes. This suggests that these patients have a neural signature or trait that makes them prone to developing chronic balance problems.

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Correlation between brain frequency band activity and the VAS measure of intensity.There was a negative correlation between delta activity and the VAS measure of intensity (r = -.59) in the frontal eye fields, while delta activity correlated positively (r = .69) with the subgenual anterior cingulate cortex, anterior medial temporal cortex, insula, vestibular cortex, and the intensity of chronic symptoms of vertigo. As for theta activity a negative correlation (r = -.49) between the precuneus/cuneus, and a positive correlation (r = .69) with subgenual anterior cingulate cortex, anterior medial temporal cortex, insula, vestibular cortex, and the VAS measure of intensity was obtained. Alpha1 (r = .40), alpha2 (r = .36), beta1, beta2, and beta3 (r = .45) were positively correlated with the VAS measure of intensity and activity in the posterior insula, the subgenual anterior cingulate cortex, anterior medial temporal cortex, and the dorsal anterior cingulate cortex, respectively, As for gamma, a negative correlation (r = -.69) was identified for the frontal eye fields, and a positive correlation (r = .60) for the posterior insula extending into the vestibular cortex.
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pone.0152309.g002: Correlation between brain frequency band activity and the VAS measure of intensity.There was a negative correlation between delta activity and the VAS measure of intensity (r = -.59) in the frontal eye fields, while delta activity correlated positively (r = .69) with the subgenual anterior cingulate cortex, anterior medial temporal cortex, insula, vestibular cortex, and the intensity of chronic symptoms of vertigo. As for theta activity a negative correlation (r = -.49) between the precuneus/cuneus, and a positive correlation (r = .69) with subgenual anterior cingulate cortex, anterior medial temporal cortex, insula, vestibular cortex, and the VAS measure of intensity was obtained. Alpha1 (r = .40), alpha2 (r = .36), beta1, beta2, and beta3 (r = .45) were positively correlated with the VAS measure of intensity and activity in the posterior insula, the subgenual anterior cingulate cortex, anterior medial temporal cortex, and the dorsal anterior cingulate cortex, respectively, As for gamma, a negative correlation (r = -.69) was identified for the frontal eye fields, and a positive correlation (r = .60) for the posterior insula extending into the vestibular cortex.

Mentions: For the alpha1, alpha2, beta1, beta2, and beta3 frequency bands, the VAS measure of intensity is correlated positively with the posterior insula extending into the vestibular cortex. In addition, for the beta1 frequency a positive correlation was obtained with the subgenual anterior cingulate cortex and anterior medial temporal cortex, while for the beta2 and beta3 frequency bands, a positive correlation was found with the dorsal anterior cingulate cortex. For the gamma frequency band, a negative correlation was identified with the frontal eye fields and a positive correlation was revealed with the posterior insula extending into the vestibular cortex. Fig 2 shows a summary of the obtained results. A correlation analysis with DHI and VAS measure of discomfort obtained no significant results for the delta, theta, alpha1, alpha2 beta1, beta2, beta3, and gamma frequency bands.


The Neural Correlates of Chronic Symptoms of Vertigo Proneness in Humans.

Alsalman O, Ost J, Vanspauwen R, Blaivie C, De Ridder D, Vanneste S - PLoS ONE (2016)

Correlation between brain frequency band activity and the VAS measure of intensity.There was a negative correlation between delta activity and the VAS measure of intensity (r = -.59) in the frontal eye fields, while delta activity correlated positively (r = .69) with the subgenual anterior cingulate cortex, anterior medial temporal cortex, insula, vestibular cortex, and the intensity of chronic symptoms of vertigo. As for theta activity a negative correlation (r = -.49) between the precuneus/cuneus, and a positive correlation (r = .69) with subgenual anterior cingulate cortex, anterior medial temporal cortex, insula, vestibular cortex, and the VAS measure of intensity was obtained. Alpha1 (r = .40), alpha2 (r = .36), beta1, beta2, and beta3 (r = .45) were positively correlated with the VAS measure of intensity and activity in the posterior insula, the subgenual anterior cingulate cortex, anterior medial temporal cortex, and the dorsal anterior cingulate cortex, respectively, As for gamma, a negative correlation (r = -.69) was identified for the frontal eye fields, and a positive correlation (r = .60) for the posterior insula extending into the vestibular cortex.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835222&req=5

pone.0152309.g002: Correlation between brain frequency band activity and the VAS measure of intensity.There was a negative correlation between delta activity and the VAS measure of intensity (r = -.59) in the frontal eye fields, while delta activity correlated positively (r = .69) with the subgenual anterior cingulate cortex, anterior medial temporal cortex, insula, vestibular cortex, and the intensity of chronic symptoms of vertigo. As for theta activity a negative correlation (r = -.49) between the precuneus/cuneus, and a positive correlation (r = .69) with subgenual anterior cingulate cortex, anterior medial temporal cortex, insula, vestibular cortex, and the VAS measure of intensity was obtained. Alpha1 (r = .40), alpha2 (r = .36), beta1, beta2, and beta3 (r = .45) were positively correlated with the VAS measure of intensity and activity in the posterior insula, the subgenual anterior cingulate cortex, anterior medial temporal cortex, and the dorsal anterior cingulate cortex, respectively, As for gamma, a negative correlation (r = -.69) was identified for the frontal eye fields, and a positive correlation (r = .60) for the posterior insula extending into the vestibular cortex.
Mentions: For the alpha1, alpha2, beta1, beta2, and beta3 frequency bands, the VAS measure of intensity is correlated positively with the posterior insula extending into the vestibular cortex. In addition, for the beta1 frequency a positive correlation was obtained with the subgenual anterior cingulate cortex and anterior medial temporal cortex, while for the beta2 and beta3 frequency bands, a positive correlation was found with the dorsal anterior cingulate cortex. For the gamma frequency band, a negative correlation was identified with the frontal eye fields and a positive correlation was revealed with the posterior insula extending into the vestibular cortex. Fig 2 shows a summary of the obtained results. A correlation analysis with DHI and VAS measure of discomfort obtained no significant results for the delta, theta, alpha1, alpha2 beta1, beta2, beta3, and gamma frequency bands.

Bottom Line: Vestibular signals are of significant importance for variable functions including gaze stabilization, spatial perception, navigation, cognition, and bodily self-consciousness.A region of interest analysis found reduced functional connectivity for gamma activity within the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex.This suggests that these patients have a neural signature or trait that makes them prone to developing chronic balance problems.

View Article: PubMed Central - PubMed

Affiliation: Lab for Clinical & Integrative Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, United States of America.

ABSTRACT
Vestibular signals are of significant importance for variable functions including gaze stabilization, spatial perception, navigation, cognition, and bodily self-consciousness. The vestibular network governs functions that might be impaired in patients affected with vestibular dysfunction. It is currently unclear how different brain regions/networks process vestibular information and integrate the information into a unified spatial percept related to somatosensory awareness and whether people with recurrent balance complaints have a neural signature as a trait affecting their development of chronic symptoms of vertigo. Pivotal evidence points to a vestibular-related brain network in humans that is widely distributed in nature. By using resting state source localized electroencephalography in non-vertiginous state, electrophysiological changes in activity and functional connectivity of 23 patients with balance complaints where chronic symptoms of vertigo and dizziness are among the most common reported complaints are analyzed and compared to healthy subjects. The analyses showed increased alpha2 activity within the posterior cingulate cortex and the precuneues/cuneus and reduced beta3 and gamma activity within the pregenual and subgenual anterior cingulate cortex for the subjects with balance complaints. These electrophysiological variations were correlated with reported chronic symptoms of vertigo intensity. A region of interest analysis found reduced functional connectivity for gamma activity within the vestibular cortex, precuneus, frontal eye field, intra-parietal sulcus, orbitofrontal cortex, and the dorsal anterior cingulate cortex. In addition, there was a positive correlation between chronic symptoms of vertigo intensity and increased alpha-gamma nesting in the left frontal eye field. When compared to healthy subjects, there is evidence of electrophysiological changes in the brain of patients with balance complaints even outside chronic symptoms of vertigo episodes. This suggests that these patients have a neural signature or trait that makes them prone to developing chronic balance problems.

Show MeSH
Related in: MedlinePlus