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Effects of teneligliptin on PDMPs and PAI-1 in patients with diabetes on hemodialysis.

Okuda Y, Omoto S, Taniura T, Shouzu A, Nomura S - Int J Gen Med (2016)

Bottom Line: Teneligliptin therapy significantly reduced plasma levels of sP-selectin, PDMPs, and PAI-1 compared with baseline levels, while significantly increasing adiponectin levels. sE-selectin and sVCAM-1 levels were significantly decreased only at 6 months.The reduction in sP-selectin, PDMPs, and PAI-1 was more significant in HD patients than in non-HD patients.By modulating PDMPs or PAI-1, teneligliptin shows an antiatherothrombotic effect that may be beneficial in the primary prevention of CVD in patients with T2DM on HD.

View Article: PubMed Central - PubMed

Affiliation: Division of Internal Medicine, Meisei Memorial Hospital, Osaka, Japan.

ABSTRACT

Background: Cardiovascular disease (CVD) is the main cause of death among hemodialysis (HD) patients. The effects of the dipeptidyl peptidase-4 inhibitor teneligliptin on CVD-related biomarkers in patients with type 2 diabetes mellitus (T2DM) receiving HD treatment are poorly understood. To determine whether teneligliptin has anti-CVD properties, we assessed its effects on soluble P-selectin (sP-selectin), platelet-derived microparticles (PDMPs), plasminogen activator inhibitor 1 (PAI-1), soluble E-selectin (sE-selectin), soluble vascular adhesion molecule 1 (sVCAM-1), and adiponectin plasma levels in HD and non-HD patients with T2DM.

Methods: Patients with T2DM eligible for teneligliptin monotherapy or combination therapy (eg, teneligliptin plus a sulfonylurea) were administered teneligliptin (20 mg/d) once daily for 6 months. Plasma levels of sP-selectin, PDMPs, PAI-1, sE-selectin, sVCAM-1, and adiponectin were measured by enzyme-linked immunosorbent assay at baseline and after 3 months and 6 months of treatment.

Results: Teneligliptin therapy significantly reduced plasma levels of sP-selectin, PDMPs, and PAI-1 compared with baseline levels, while significantly increasing adiponectin levels. sE-selectin and sVCAM-1 levels were significantly decreased only at 6 months. The reduction in sP-selectin, PDMPs, and PAI-1 was more significant in HD patients than in non-HD patients. However, the improvement in adiponectin levels was unchanged with HD treatment.

Conclusion: By modulating PDMPs or PAI-1, teneligliptin shows an antiatherothrombotic effect that may be beneficial in the primary prevention of CVD in patients with T2DM on HD.

No MeSH data available.


Related in: MedlinePlus

Plasma concentrations of sP-selectin (A), PDMP (B), PAI-1 (C), adiponectin (D), sE-selectin (E), and sVCAM-1 (F) before and after teneligliptin treatment of patients with diabetes.Notes: Data are shown as mean ± SD. P-values shown for 0 M vs 3 M and 0 M vs 6 M.Abbreviations: sP-selectin, soluble P-selectin; PDMP, platelet-derived microparticle; PAI-1, plasminogen activator inhibitor; sE-selectin, soluble E-selectin; sVCAM-1, soluble vascular cell adhesion molecule; 0 M, 0 months (baseline); 3 M, 3 months after treatment; 6 M, 6 months after treatment; NS, not significant; SD, standard deviation.
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f1-ijgm-9-065: Plasma concentrations of sP-selectin (A), PDMP (B), PAI-1 (C), adiponectin (D), sE-selectin (E), and sVCAM-1 (F) before and after teneligliptin treatment of patients with diabetes.Notes: Data are shown as mean ± SD. P-values shown for 0 M vs 3 M and 0 M vs 6 M.Abbreviations: sP-selectin, soluble P-selectin; PDMP, platelet-derived microparticle; PAI-1, plasminogen activator inhibitor; sE-selectin, soluble E-selectin; sVCAM-1, soluble vascular cell adhesion molecule; 0 M, 0 months (baseline); 3 M, 3 months after treatment; 6 M, 6 months after treatment; NS, not significant; SD, standard deviation.

Mentions: Administration of teneligliptin to 103 patients for 3 months significantly reduced fasting blood glucose and HbA1c levels (data not shown). In addition, both 3-month and 6-month administration significantly reduced plasma concentrations of sP-selectin, PDMPs, and PAI-1, relative to baseline (3 months, P<0.05; 6 months, P<0.01 each; Figure 1A–C). Furthermore, teneligliptin treatment significantly increased adiponectin concentrations after 3 months (P<0.05) and 6 months (P<0.01), relative to baseline (Figure 1D). Teneligliptin also decreased sE-selectin and sVCAM-1 concentrations after 6 months, relative to baseline, although the differences were not significant after 3 months (Figure 1E and F).


Effects of teneligliptin on PDMPs and PAI-1 in patients with diabetes on hemodialysis.

Okuda Y, Omoto S, Taniura T, Shouzu A, Nomura S - Int J Gen Med (2016)

Plasma concentrations of sP-selectin (A), PDMP (B), PAI-1 (C), adiponectin (D), sE-selectin (E), and sVCAM-1 (F) before and after teneligliptin treatment of patients with diabetes.Notes: Data are shown as mean ± SD. P-values shown for 0 M vs 3 M and 0 M vs 6 M.Abbreviations: sP-selectin, soluble P-selectin; PDMP, platelet-derived microparticle; PAI-1, plasminogen activator inhibitor; sE-selectin, soluble E-selectin; sVCAM-1, soluble vascular cell adhesion molecule; 0 M, 0 months (baseline); 3 M, 3 months after treatment; 6 M, 6 months after treatment; NS, not significant; SD, standard deviation.
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getmorefigures.php?uid=PMC4835142&req=5

f1-ijgm-9-065: Plasma concentrations of sP-selectin (A), PDMP (B), PAI-1 (C), adiponectin (D), sE-selectin (E), and sVCAM-1 (F) before and after teneligliptin treatment of patients with diabetes.Notes: Data are shown as mean ± SD. P-values shown for 0 M vs 3 M and 0 M vs 6 M.Abbreviations: sP-selectin, soluble P-selectin; PDMP, platelet-derived microparticle; PAI-1, plasminogen activator inhibitor; sE-selectin, soluble E-selectin; sVCAM-1, soluble vascular cell adhesion molecule; 0 M, 0 months (baseline); 3 M, 3 months after treatment; 6 M, 6 months after treatment; NS, not significant; SD, standard deviation.
Mentions: Administration of teneligliptin to 103 patients for 3 months significantly reduced fasting blood glucose and HbA1c levels (data not shown). In addition, both 3-month and 6-month administration significantly reduced plasma concentrations of sP-selectin, PDMPs, and PAI-1, relative to baseline (3 months, P<0.05; 6 months, P<0.01 each; Figure 1A–C). Furthermore, teneligliptin treatment significantly increased adiponectin concentrations after 3 months (P<0.05) and 6 months (P<0.01), relative to baseline (Figure 1D). Teneligliptin also decreased sE-selectin and sVCAM-1 concentrations after 6 months, relative to baseline, although the differences were not significant after 3 months (Figure 1E and F).

Bottom Line: Teneligliptin therapy significantly reduced plasma levels of sP-selectin, PDMPs, and PAI-1 compared with baseline levels, while significantly increasing adiponectin levels. sE-selectin and sVCAM-1 levels were significantly decreased only at 6 months.The reduction in sP-selectin, PDMPs, and PAI-1 was more significant in HD patients than in non-HD patients.By modulating PDMPs or PAI-1, teneligliptin shows an antiatherothrombotic effect that may be beneficial in the primary prevention of CVD in patients with T2DM on HD.

View Article: PubMed Central - PubMed

Affiliation: Division of Internal Medicine, Meisei Memorial Hospital, Osaka, Japan.

ABSTRACT

Background: Cardiovascular disease (CVD) is the main cause of death among hemodialysis (HD) patients. The effects of the dipeptidyl peptidase-4 inhibitor teneligliptin on CVD-related biomarkers in patients with type 2 diabetes mellitus (T2DM) receiving HD treatment are poorly understood. To determine whether teneligliptin has anti-CVD properties, we assessed its effects on soluble P-selectin (sP-selectin), platelet-derived microparticles (PDMPs), plasminogen activator inhibitor 1 (PAI-1), soluble E-selectin (sE-selectin), soluble vascular adhesion molecule 1 (sVCAM-1), and adiponectin plasma levels in HD and non-HD patients with T2DM.

Methods: Patients with T2DM eligible for teneligliptin monotherapy or combination therapy (eg, teneligliptin plus a sulfonylurea) were administered teneligliptin (20 mg/d) once daily for 6 months. Plasma levels of sP-selectin, PDMPs, PAI-1, sE-selectin, sVCAM-1, and adiponectin were measured by enzyme-linked immunosorbent assay at baseline and after 3 months and 6 months of treatment.

Results: Teneligliptin therapy significantly reduced plasma levels of sP-selectin, PDMPs, and PAI-1 compared with baseline levels, while significantly increasing adiponectin levels. sE-selectin and sVCAM-1 levels were significantly decreased only at 6 months. The reduction in sP-selectin, PDMPs, and PAI-1 was more significant in HD patients than in non-HD patients. However, the improvement in adiponectin levels was unchanged with HD treatment.

Conclusion: By modulating PDMPs or PAI-1, teneligliptin shows an antiatherothrombotic effect that may be beneficial in the primary prevention of CVD in patients with T2DM on HD.

No MeSH data available.


Related in: MedlinePlus