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Effects of exercise intervention in breast cancer survivors: a meta-analysis of 33 randomized controlled trails.

Zhu G, Zhang X, Wang Y, Xiong H, Zhao Y, Sun F - Onco Targets Ther (2016)

Bottom Line: A systematic search of PubMed, Elsevier, and Google scholar was conducted up to March 2015.In addition, the serum concentration of insulin, insulin-like growth factor-II, and insulin-like growth factor binding protein-1 was significantly reduced in exercise intervention group.However, based on the current data of this meta-analysis, there were no significant differences in sleep dysfunction or fatigue between groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, People's Republic of China.

ABSTRACT

Background: Exercise is associated with favorable outcomes in cancer survivors. The purpose of this meta-analysis is to comprehensively summarize the effects of exercise intervention in breast cancer survivors.

Methods: A systematic search of PubMed, Elsevier, and Google scholar was conducted up to March 2015. References from relevant meta-analyses and reviews were also checked.

Results: Thirty-three randomized controlled trials were included in this meta-analysis, including 2,659 breast cancer survivors. Compared with the control group, quality of life was significantly improved in exercise intervention group, especially in mental health and general health subscales of short form 36 questionnaire, as well as emotion well-being and social well-being subscales of the Functional Assessment of Cancer Therapy. Besides, exercise alleviated the symptoms of depression and anxiety in the exercise group. Furthermore, exercise was also associated with positive outcomes in body mass index, lean mass, and muscle strength. In addition, the serum concentration of insulin, insulin-like growth factor-II, and insulin-like growth factor binding protein-1 was significantly reduced in exercise intervention group. However, based on the current data of this meta-analysis, there were no significant differences in sleep dysfunction or fatigue between groups.

Conclusion: Our study suggested that exercise intervention was beneficial to breast cancer survivors. Therefore, exercise should be recommended to this patient group.

No MeSH data available.


Related in: MedlinePlus

The association between exercise intervention and insulin and IGFBP-1 in breast cancer survivors.Notes: (A) Insulin and (B) IGFBP-1.Abbreviations: CI, confidence interval; IFGBP-1, insulin-like growth factor binding protein-1; SD, standard deviation; df, degree of freedom.
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f7-ott-9-2153: The association between exercise intervention and insulin and IGFBP-1 in breast cancer survivors.Notes: (A) Insulin and (B) IGFBP-1.Abbreviations: CI, confidence interval; IFGBP-1, insulin-like growth factor binding protein-1; SD, standard deviation; df, degree of freedom.

Mentions: Eight physiological markers were examined in this meta-analysis (Table 3). When the data of postintervention were used, only insulin (I2=95%, P=0.05, 95% CI: −13.64, 0.06) and insulin-like growth factor binding protein (IGFBP)-1 (I2=46%, P<0.00001, 95% CI: −4.40, −1.91) were signifi-cantly reduced after exercise intervention. However, based on the changed serum concentration of physiological markers after intervention (postintervention minus baseline), exercise significantly reduced the serum concentration of insulin (I2=97%, P<0.00001, 95% CI: −9.26, −0.33, Figure 7), IGFBP-1 (I2=0%, P<0.00001, 95% CI: −3.93, −1.93, Figure 7), and insulin-like growth factor (IGF)-II (I2=0%, P<0.00001, 95% CI: −61.41, −47.00). Significant increases were shown in interleukin (IL)-6 (I2=69%, P=0.02, 95% CI: 0.27, 2.65) and glucose (I2=99%, P<0.00001, 95% CI: 0.27, 2.65). There were substantial heterogeneity in some of the physiological markers, and evident publication bias was only observed in IL-6 (P=0.046) (Table 3).


Effects of exercise intervention in breast cancer survivors: a meta-analysis of 33 randomized controlled trails.

Zhu G, Zhang X, Wang Y, Xiong H, Zhao Y, Sun F - Onco Targets Ther (2016)

The association between exercise intervention and insulin and IGFBP-1 in breast cancer survivors.Notes: (A) Insulin and (B) IGFBP-1.Abbreviations: CI, confidence interval; IFGBP-1, insulin-like growth factor binding protein-1; SD, standard deviation; df, degree of freedom.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4835133&req=5

f7-ott-9-2153: The association between exercise intervention and insulin and IGFBP-1 in breast cancer survivors.Notes: (A) Insulin and (B) IGFBP-1.Abbreviations: CI, confidence interval; IFGBP-1, insulin-like growth factor binding protein-1; SD, standard deviation; df, degree of freedom.
Mentions: Eight physiological markers were examined in this meta-analysis (Table 3). When the data of postintervention were used, only insulin (I2=95%, P=0.05, 95% CI: −13.64, 0.06) and insulin-like growth factor binding protein (IGFBP)-1 (I2=46%, P<0.00001, 95% CI: −4.40, −1.91) were signifi-cantly reduced after exercise intervention. However, based on the changed serum concentration of physiological markers after intervention (postintervention minus baseline), exercise significantly reduced the serum concentration of insulin (I2=97%, P<0.00001, 95% CI: −9.26, −0.33, Figure 7), IGFBP-1 (I2=0%, P<0.00001, 95% CI: −3.93, −1.93, Figure 7), and insulin-like growth factor (IGF)-II (I2=0%, P<0.00001, 95% CI: −61.41, −47.00). Significant increases were shown in interleukin (IL)-6 (I2=69%, P=0.02, 95% CI: 0.27, 2.65) and glucose (I2=99%, P<0.00001, 95% CI: 0.27, 2.65). There were substantial heterogeneity in some of the physiological markers, and evident publication bias was only observed in IL-6 (P=0.046) (Table 3).

Bottom Line: A systematic search of PubMed, Elsevier, and Google scholar was conducted up to March 2015.In addition, the serum concentration of insulin, insulin-like growth factor-II, and insulin-like growth factor binding protein-1 was significantly reduced in exercise intervention group.However, based on the current data of this meta-analysis, there were no significant differences in sleep dysfunction or fatigue between groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, People's Republic of China.

ABSTRACT

Background: Exercise is associated with favorable outcomes in cancer survivors. The purpose of this meta-analysis is to comprehensively summarize the effects of exercise intervention in breast cancer survivors.

Methods: A systematic search of PubMed, Elsevier, and Google scholar was conducted up to March 2015. References from relevant meta-analyses and reviews were also checked.

Results: Thirty-three randomized controlled trials were included in this meta-analysis, including 2,659 breast cancer survivors. Compared with the control group, quality of life was significantly improved in exercise intervention group, especially in mental health and general health subscales of short form 36 questionnaire, as well as emotion well-being and social well-being subscales of the Functional Assessment of Cancer Therapy. Besides, exercise alleviated the symptoms of depression and anxiety in the exercise group. Furthermore, exercise was also associated with positive outcomes in body mass index, lean mass, and muscle strength. In addition, the serum concentration of insulin, insulin-like growth factor-II, and insulin-like growth factor binding protein-1 was significantly reduced in exercise intervention group. However, based on the current data of this meta-analysis, there were no significant differences in sleep dysfunction or fatigue between groups.

Conclusion: Our study suggested that exercise intervention was beneficial to breast cancer survivors. Therefore, exercise should be recommended to this patient group.

No MeSH data available.


Related in: MedlinePlus