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Sleep deprivation disturbed regional brain activity in healthy subjects: evidence from a functional magnetic resonance-imaging study.

Wang L, Chen Y, Yao Y, Pan Y, Sun Y - Neuropsychiatr Dis Treat (2016)

Bottom Line: In the SD group, mean ALFF of the right claustrum showed a significant positive correlation with accuracy rate (r=0.687, P=0.013) and a negative correlation with lapse rate (r=-0.706, P=0.01).Mean ALFF of the dorsolateral prefrontal cortex showed a significant positive correlation with response time (r=0.675, P=0.016).SD disturbed the regional brain activity of the default-mode network, its anticorrelated "task-positive" network, and the advanced cognitive function brain areas.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

ABSTRACT

Objective: The aim of this study was to use amplitude of low-frequency fluctuation (ALFF) to explore regional brain activities in healthy subjects after sleep deprivation (SD).

Materials and methods: A total of 16 healthy subjects (eight females, eight males) underwent the session twice: once was after normal sleep (NS), and the other was after SD. ALFF was used to assess local brain features. The mean ALFF-signal values of the different brain areas were evaluated to investigate relationships with clinical features and were analyzed with a receiver-operating characteristic curve.

Results: Compared with NS subjects, SD subjects showed a lower response-accuracy rate, longer response time, and higher lapse rate. Compared with NS subjects, SD subjects showed higher ALFF area in the right cuneus and lower ALFF area in the right lentiform nucleus, right claustrum, left dorsolateral prefrontal cortex, and left inferior parietal cortex. ALFF differences in regional brain areas showed high sensitivity and specificity. In the SD group, mean ALFF of the right claustrum showed a significant positive correlation with accuracy rate (r=0.687, P=0.013) and a negative correlation with lapse rate (r=-0.706, P=0.01). Mean ALFF of the dorsolateral prefrontal cortex showed a significant positive correlation with response time (r=0.675, P=0.016).

Conclusion: SD disturbed the regional brain activity of the default-mode network, its anticorrelated "task-positive" network, and the advanced cognitive function brain areas.

No MeSH data available.


Related in: MedlinePlus

ROC curve of the mean ALFF value of the different brain areas.Note: The different brain areas showed high sensitivity and specificity.Abbreviations: ROC, receiver-operating characteristic; ALFF, amplitude of low-frequency fluctuation.
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f3-ndt-12-801: ROC curve of the mean ALFF value of the different brain areas.Note: The different brain areas showed high sensitivity and specificity.Abbreviations: ROC, receiver-operating characteristic; ALFF, amplitude of low-frequency fluctuation.

Mentions: Figure 2 shows the mean ALFF-signal values of the altered regional brain areas. These different values were used for ROC-curve analysis to investigate whether these specific ALFF differences had the sensitivity and specificity to distinguish the SD group from the NS group. ROC-curve analysis showed that the area under the curve of the five different brain areas (from cluster 1 to cluster 5) was 0.861 with a cutoff point of 0.996 (mean ALFF-signal value), 0.757 with a cutoff point of −0.538, 0.944 with a cutoff point of −0.93, 0.826 with a cutoff point of 0.084, and 0.736 with a cutoff point of 0.471. Further diagnostic analysis showed that the different brain areas alone discriminated SD status from NS status with high sensitivity and specificity: corresponding values from clusters 1–5 were 0.667 and 0.917, 0.667 and 0.833, 0.833 and 0.917, 0.833 and 0.833, and 0.583 and 0.833, respectively. Details are presented in Figure 3.


Sleep deprivation disturbed regional brain activity in healthy subjects: evidence from a functional magnetic resonance-imaging study.

Wang L, Chen Y, Yao Y, Pan Y, Sun Y - Neuropsychiatr Dis Treat (2016)

ROC curve of the mean ALFF value of the different brain areas.Note: The different brain areas showed high sensitivity and specificity.Abbreviations: ROC, receiver-operating characteristic; ALFF, amplitude of low-frequency fluctuation.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4835129&req=5

f3-ndt-12-801: ROC curve of the mean ALFF value of the different brain areas.Note: The different brain areas showed high sensitivity and specificity.Abbreviations: ROC, receiver-operating characteristic; ALFF, amplitude of low-frequency fluctuation.
Mentions: Figure 2 shows the mean ALFF-signal values of the altered regional brain areas. These different values were used for ROC-curve analysis to investigate whether these specific ALFF differences had the sensitivity and specificity to distinguish the SD group from the NS group. ROC-curve analysis showed that the area under the curve of the five different brain areas (from cluster 1 to cluster 5) was 0.861 with a cutoff point of 0.996 (mean ALFF-signal value), 0.757 with a cutoff point of −0.538, 0.944 with a cutoff point of −0.93, 0.826 with a cutoff point of 0.084, and 0.736 with a cutoff point of 0.471. Further diagnostic analysis showed that the different brain areas alone discriminated SD status from NS status with high sensitivity and specificity: corresponding values from clusters 1–5 were 0.667 and 0.917, 0.667 and 0.833, 0.833 and 0.917, 0.833 and 0.833, and 0.583 and 0.833, respectively. Details are presented in Figure 3.

Bottom Line: In the SD group, mean ALFF of the right claustrum showed a significant positive correlation with accuracy rate (r=0.687, P=0.013) and a negative correlation with lapse rate (r=-0.706, P=0.01).Mean ALFF of the dorsolateral prefrontal cortex showed a significant positive correlation with response time (r=0.675, P=0.016).SD disturbed the regional brain activity of the default-mode network, its anticorrelated "task-positive" network, and the advanced cognitive function brain areas.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

ABSTRACT

Objective: The aim of this study was to use amplitude of low-frequency fluctuation (ALFF) to explore regional brain activities in healthy subjects after sleep deprivation (SD).

Materials and methods: A total of 16 healthy subjects (eight females, eight males) underwent the session twice: once was after normal sleep (NS), and the other was after SD. ALFF was used to assess local brain features. The mean ALFF-signal values of the different brain areas were evaluated to investigate relationships with clinical features and were analyzed with a receiver-operating characteristic curve.

Results: Compared with NS subjects, SD subjects showed a lower response-accuracy rate, longer response time, and higher lapse rate. Compared with NS subjects, SD subjects showed higher ALFF area in the right cuneus and lower ALFF area in the right lentiform nucleus, right claustrum, left dorsolateral prefrontal cortex, and left inferior parietal cortex. ALFF differences in regional brain areas showed high sensitivity and specificity. In the SD group, mean ALFF of the right claustrum showed a significant positive correlation with accuracy rate (r=0.687, P=0.013) and a negative correlation with lapse rate (r=-0.706, P=0.01). Mean ALFF of the dorsolateral prefrontal cortex showed a significant positive correlation with response time (r=0.675, P=0.016).

Conclusion: SD disturbed the regional brain activity of the default-mode network, its anticorrelated "task-positive" network, and the advanced cognitive function brain areas.

No MeSH data available.


Related in: MedlinePlus