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Sleep deprivation disturbed regional brain activity in healthy subjects: evidence from a functional magnetic resonance-imaging study.

Wang L, Chen Y, Yao Y, Pan Y, Sun Y - Neuropsychiatr Dis Treat (2016)

Bottom Line: In the SD group, mean ALFF of the right claustrum showed a significant positive correlation with accuracy rate (r=0.687, P=0.013) and a negative correlation with lapse rate (r=-0.706, P=0.01).Mean ALFF of the dorsolateral prefrontal cortex showed a significant positive correlation with response time (r=0.675, P=0.016).SD disturbed the regional brain activity of the default-mode network, its anticorrelated "task-positive" network, and the advanced cognitive function brain areas.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

ABSTRACT

Objective: The aim of this study was to use amplitude of low-frequency fluctuation (ALFF) to explore regional brain activities in healthy subjects after sleep deprivation (SD).

Materials and methods: A total of 16 healthy subjects (eight females, eight males) underwent the session twice: once was after normal sleep (NS), and the other was after SD. ALFF was used to assess local brain features. The mean ALFF-signal values of the different brain areas were evaluated to investigate relationships with clinical features and were analyzed with a receiver-operating characteristic curve.

Results: Compared with NS subjects, SD subjects showed a lower response-accuracy rate, longer response time, and higher lapse rate. Compared with NS subjects, SD subjects showed higher ALFF area in the right cuneus and lower ALFF area in the right lentiform nucleus, right claustrum, left dorsolateral prefrontal cortex, and left inferior parietal cortex. ALFF differences in regional brain areas showed high sensitivity and specificity. In the SD group, mean ALFF of the right claustrum showed a significant positive correlation with accuracy rate (r=0.687, P=0.013) and a negative correlation with lapse rate (r=-0.706, P=0.01). Mean ALFF of the dorsolateral prefrontal cortex showed a significant positive correlation with response time (r=0.675, P=0.016).

Conclusion: SD disturbed the regional brain activity of the default-mode network, its anticorrelated "task-positive" network, and the advanced cognitive function brain areas.

No MeSH data available.


Related in: MedlinePlus

ALFF differences between the SD and NS groups.Notes: Colors in the map represent differences. Red signifies higher ALFF area in the right cuneus, and blue signifies lower ALFF area in the right lentiform nucleus, right claustrum, left middle frontal gyrus, and left inferior parietal cortices.Abbreviations: ALFF, amplitude of low-frequency fluctuation; SD, sleep deprivation; NS, normal sleep.
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f1-ndt-12-801: ALFF differences between the SD and NS groups.Notes: Colors in the map represent differences. Red signifies higher ALFF area in the right cuneus, and blue signifies lower ALFF area in the right lentiform nucleus, right claustrum, left middle frontal gyrus, and left inferior parietal cortices.Abbreviations: ALFF, amplitude of low-frequency fluctuation; SD, sleep deprivation; NS, normal sleep.

Mentions: Compared with the NS subjects, the SD subjects showed higher ALFF area in the right cuneus (Brodmann’s area [BA] 17, BA 18), and lower ALFF area in the right lentiform nucleus, right claustrum, left middle frontal gyrus (BA 46), and left inferior parietal cortex (IPC; BA 39). Details are presented in Figure 1 and Table 1.


Sleep deprivation disturbed regional brain activity in healthy subjects: evidence from a functional magnetic resonance-imaging study.

Wang L, Chen Y, Yao Y, Pan Y, Sun Y - Neuropsychiatr Dis Treat (2016)

ALFF differences between the SD and NS groups.Notes: Colors in the map represent differences. Red signifies higher ALFF area in the right cuneus, and blue signifies lower ALFF area in the right lentiform nucleus, right claustrum, left middle frontal gyrus, and left inferior parietal cortices.Abbreviations: ALFF, amplitude of low-frequency fluctuation; SD, sleep deprivation; NS, normal sleep.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4835129&req=5

f1-ndt-12-801: ALFF differences between the SD and NS groups.Notes: Colors in the map represent differences. Red signifies higher ALFF area in the right cuneus, and blue signifies lower ALFF area in the right lentiform nucleus, right claustrum, left middle frontal gyrus, and left inferior parietal cortices.Abbreviations: ALFF, amplitude of low-frequency fluctuation; SD, sleep deprivation; NS, normal sleep.
Mentions: Compared with the NS subjects, the SD subjects showed higher ALFF area in the right cuneus (Brodmann’s area [BA] 17, BA 18), and lower ALFF area in the right lentiform nucleus, right claustrum, left middle frontal gyrus (BA 46), and left inferior parietal cortex (IPC; BA 39). Details are presented in Figure 1 and Table 1.

Bottom Line: In the SD group, mean ALFF of the right claustrum showed a significant positive correlation with accuracy rate (r=0.687, P=0.013) and a negative correlation with lapse rate (r=-0.706, P=0.01).Mean ALFF of the dorsolateral prefrontal cortex showed a significant positive correlation with response time (r=0.675, P=0.016).SD disturbed the regional brain activity of the default-mode network, its anticorrelated "task-positive" network, and the advanced cognitive function brain areas.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

ABSTRACT

Objective: The aim of this study was to use amplitude of low-frequency fluctuation (ALFF) to explore regional brain activities in healthy subjects after sleep deprivation (SD).

Materials and methods: A total of 16 healthy subjects (eight females, eight males) underwent the session twice: once was after normal sleep (NS), and the other was after SD. ALFF was used to assess local brain features. The mean ALFF-signal values of the different brain areas were evaluated to investigate relationships with clinical features and were analyzed with a receiver-operating characteristic curve.

Results: Compared with NS subjects, SD subjects showed a lower response-accuracy rate, longer response time, and higher lapse rate. Compared with NS subjects, SD subjects showed higher ALFF area in the right cuneus and lower ALFF area in the right lentiform nucleus, right claustrum, left dorsolateral prefrontal cortex, and left inferior parietal cortex. ALFF differences in regional brain areas showed high sensitivity and specificity. In the SD group, mean ALFF of the right claustrum showed a significant positive correlation with accuracy rate (r=0.687, P=0.013) and a negative correlation with lapse rate (r=-0.706, P=0.01). Mean ALFF of the dorsolateral prefrontal cortex showed a significant positive correlation with response time (r=0.675, P=0.016).

Conclusion: SD disturbed the regional brain activity of the default-mode network, its anticorrelated "task-positive" network, and the advanced cognitive function brain areas.

No MeSH data available.


Related in: MedlinePlus