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Simple models based on gamma-glutamyl transpeptidase and platelets for predicting survival in hepatitis B-associated hepatocellular carcinoma.

Pang Q, Bi JB, Wang ZX, Xu XS, Qu K, Miao RC, Chen W, Zhou YY, Liu C - Onco Targets Ther (2016)

Bottom Line: GPR and S-index were both found to be significantly associated with survival by univariate log-rank test.Multivariate analysis identified tumor size ≥5 and high level of GPR, but not high Barcelona Clinic Liver Cancer stage or S-index, as independent factors for predicting poor overall survival and recurrence-free survival.The GPR is an effective preoperative predictor for outcomes in hepatitis B-associated HCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Shaanxi Province, People's Republic of China.

ABSTRACT

Background: Several hepatic cirrhosis-derived noninvasive models have been developed to predict the incidence and outcomes of hepatocellular carcinoma (HCC). We aimed to investigate the prognostic significance of the two novel established cirrhosis-associated models based on gamma-glutamyl transpeptidase (GGT) and platelets in hepatitis B-associated HCC.

Methods: We retrospectively evaluated 182 HCC patients with positive hepatitis B surface antigen who received radical therapy at a single institution between 2002 and 2012. Laboratory data prior to operation were collected to calculate the GGT to platelets ratio (GPR) and the S-index. Predictive factors associated with overall survival and recurrence-free survival were assessed using log-rank test and multivariate Cox analysis. Additional analyses were performed after patients were stratified based on cirrhosis status, tumor size, therapy methods, and so forth, to investigate the prognostic significance in different subgroups.

Results: During a median follow-up time of 45.0 months, a total of 88 (48.4%) patients died and 79 (43.4%) patients recurred. The cut-off points for GPR and S-index in predicting death were determined to be 0.76 and 0.56, respectively. Compared with patients with a lower GPR, those with GPR ≥0.76 had a higher probability of cirrhosis and a larger tumor (both P<0.05). GPR and S-index were both found to be significantly associated with survival by univariate log-rank test. Multivariate analysis identified tumor size ≥5 and high level of GPR, but not high Barcelona Clinic Liver Cancer stage or S-index, as independent factors for predicting poor overall survival and recurrence-free survival.

Conclusion: The GPR is an effective preoperative predictor for outcomes in hepatitis B-associated HCC.

No MeSH data available.


Related in: MedlinePlus

The box plots reflect the associations between GPR and tumor size (A and B) and between S-index and Child–Pugh stage (C and D).Notes: Scatter plot (C) reflects the associations between GPR and tumor size, and the diagnostic performance of S-index (D) in detecting the Child-Pugh B/C stage. The P-values in (A) and (C) were calculated by Wilcoxon test.Abbreviations: GPR, gamma-glutamyl transpeptidase to platelet ratio; ROC, receiver operating characteristic.
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f2-ott-9-2099: The box plots reflect the associations between GPR and tumor size (A and B) and between S-index and Child–Pugh stage (C and D).Notes: Scatter plot (C) reflects the associations between GPR and tumor size, and the diagnostic performance of S-index (D) in detecting the Child-Pugh B/C stage. The P-values in (A) and (C) were calculated by Wilcoxon test.Abbreviations: GPR, gamma-glutamyl transpeptidase to platelet ratio; ROC, receiver operating characteristic.

Mentions: Figure 2A and B further indicated that GPR score was positively related with tumor size, and Figure 2C and D showed that patients with Child–Pugh B/C stage had a high level of S-index, compared to patients with Child–Pugh A stage.


Simple models based on gamma-glutamyl transpeptidase and platelets for predicting survival in hepatitis B-associated hepatocellular carcinoma.

Pang Q, Bi JB, Wang ZX, Xu XS, Qu K, Miao RC, Chen W, Zhou YY, Liu C - Onco Targets Ther (2016)

The box plots reflect the associations between GPR and tumor size (A and B) and between S-index and Child–Pugh stage (C and D).Notes: Scatter plot (C) reflects the associations between GPR and tumor size, and the diagnostic performance of S-index (D) in detecting the Child-Pugh B/C stage. The P-values in (A) and (C) were calculated by Wilcoxon test.Abbreviations: GPR, gamma-glutamyl transpeptidase to platelet ratio; ROC, receiver operating characteristic.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4835119&req=5

f2-ott-9-2099: The box plots reflect the associations between GPR and tumor size (A and B) and between S-index and Child–Pugh stage (C and D).Notes: Scatter plot (C) reflects the associations between GPR and tumor size, and the diagnostic performance of S-index (D) in detecting the Child-Pugh B/C stage. The P-values in (A) and (C) were calculated by Wilcoxon test.Abbreviations: GPR, gamma-glutamyl transpeptidase to platelet ratio; ROC, receiver operating characteristic.
Mentions: Figure 2A and B further indicated that GPR score was positively related with tumor size, and Figure 2C and D showed that patients with Child–Pugh B/C stage had a high level of S-index, compared to patients with Child–Pugh A stage.

Bottom Line: GPR and S-index were both found to be significantly associated with survival by univariate log-rank test.Multivariate analysis identified tumor size ≥5 and high level of GPR, but not high Barcelona Clinic Liver Cancer stage or S-index, as independent factors for predicting poor overall survival and recurrence-free survival.The GPR is an effective preoperative predictor for outcomes in hepatitis B-associated HCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Shaanxi Province, People's Republic of China.

ABSTRACT

Background: Several hepatic cirrhosis-derived noninvasive models have been developed to predict the incidence and outcomes of hepatocellular carcinoma (HCC). We aimed to investigate the prognostic significance of the two novel established cirrhosis-associated models based on gamma-glutamyl transpeptidase (GGT) and platelets in hepatitis B-associated HCC.

Methods: We retrospectively evaluated 182 HCC patients with positive hepatitis B surface antigen who received radical therapy at a single institution between 2002 and 2012. Laboratory data prior to operation were collected to calculate the GGT to platelets ratio (GPR) and the S-index. Predictive factors associated with overall survival and recurrence-free survival were assessed using log-rank test and multivariate Cox analysis. Additional analyses were performed after patients were stratified based on cirrhosis status, tumor size, therapy methods, and so forth, to investigate the prognostic significance in different subgroups.

Results: During a median follow-up time of 45.0 months, a total of 88 (48.4%) patients died and 79 (43.4%) patients recurred. The cut-off points for GPR and S-index in predicting death were determined to be 0.76 and 0.56, respectively. Compared with patients with a lower GPR, those with GPR ≥0.76 had a higher probability of cirrhosis and a larger tumor (both P<0.05). GPR and S-index were both found to be significantly associated with survival by univariate log-rank test. Multivariate analysis identified tumor size ≥5 and high level of GPR, but not high Barcelona Clinic Liver Cancer stage or S-index, as independent factors for predicting poor overall survival and recurrence-free survival.

Conclusion: The GPR is an effective preoperative predictor for outcomes in hepatitis B-associated HCC.

No MeSH data available.


Related in: MedlinePlus