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Obesity and the Role of Short Duration Submaximal Work on Cardiovascular and Cerebral Hemodynamics.

Cavuoto LA, Maikala RV - PLoS ONE (2016)

Bottom Line: The non-obese group reached ~43% of their predicted maximal aerobic capacity as compared to ~34% in the obese group, with the non-obese working at a relatively higher workload and for more duration than the obese.The obese had elevated baseline heart rate and reduced whole-body oxygen uptake per body weight at baseline and task termination.However, both groups exhibited similar cerebral hemodynamics during recovery.

View Article: PubMed Central - PubMed

Affiliation: Industrial and Systems Engineering, University at Buffalo, Buffalo, New York, 14260, United States of America.

ABSTRACT
The objective of this study was to compare gas exchange, cardiac and cerebral hemodynamic responses between 10 non-obese and 10 obese men during submaximal work. With the increasing prevalence of obesity, there is a need to understand the impact of obesity on work-induced responses. Participants completed a step-wise incremental cycling until they reached 60% of their age-predicted maximum heart rate. Gas exchange, cardiac and pre-frontal cortex hemodynamic responses were simultaneously measured during rest, work, and recovery. The non-obese group reached ~43% of their predicted maximal aerobic capacity as compared to ~34% in the obese group, with the non-obese working at a relatively higher workload and for more duration than the obese. The obese had elevated baseline heart rate and reduced whole-body oxygen uptake per body weight at baseline and task termination. Other cardiac and cerebral responses, although increased from baseline, were similar between groups during submaximal effort. In the obese, during recovery oxygen uptake and heart-rate recovery were slowest; cardiac output and rate pressure product were greatest, and left ventricle ejection time was shortest. However, both groups exhibited similar cerebral hemodynamics during recovery. These finding imply that, irrespective of their low aerobic fitness, obesity does not impair myocardial performance and cerebrovascular function during graded submaximal work, however, recovery from a short duration of work was influenced by their fitness level. Since a majority of activities of daily living are performed at individual's submaximal level, understanding influence of obesity on submaximal work is critical.

No MeSH data available.


Related in: MedlinePlus

Prefrontal cortex oxygenated hemoglobin (HbO2; (a) left side, (b) right side) and total oxygenation index (TOI; (c) left side, (d) right side) in obese and non-obese groups during incremental submaximal cycling.
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pone.0153826.g003: Prefrontal cortex oxygenated hemoglobin (HbO2; (a) left side, (b) right side) and total oxygenation index (TOI; (c) left side, (d) right side) in obese and non-obese groups during incremental submaximal cycling.

Mentions: The trends in cerebral hemodynamics were consistent between groups and between both sides of the forehead (see Fig 3). Both groups exhibited an increase in oxygenated hemoglobin with increasing time normalized to task duration (p<0.001, Fig 3A and 3B). There was also a significant effect of time on the TOI (p<0.001, Fig 3C and 3D), however none of the measures showed significant group or group by time interaction effects. The correlations between systolic blood pressure and oxygenated hemoglobin were r = -0.38 (left region, p = 0.036) and -0.44 (right region, p = 0.016) for the non-obese group and r = -0.42 for both regions for the obese group (p = 0.031 and 0.033, respectively). Correlations between diastolic blood pressure and oxygenated hemoglobin were r = -0.72 (left region, p<0.001) and -0.49 (right region, p = 0.065) for the non-obese group while they were not significant for the obese group (r = -0.09 (left region, p = 0.67) and -0.17 (right region, p = 0.40).


Obesity and the Role of Short Duration Submaximal Work on Cardiovascular and Cerebral Hemodynamics.

Cavuoto LA, Maikala RV - PLoS ONE (2016)

Prefrontal cortex oxygenated hemoglobin (HbO2; (a) left side, (b) right side) and total oxygenation index (TOI; (c) left side, (d) right side) in obese and non-obese groups during incremental submaximal cycling.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835079&req=5

pone.0153826.g003: Prefrontal cortex oxygenated hemoglobin (HbO2; (a) left side, (b) right side) and total oxygenation index (TOI; (c) left side, (d) right side) in obese and non-obese groups during incremental submaximal cycling.
Mentions: The trends in cerebral hemodynamics were consistent between groups and between both sides of the forehead (see Fig 3). Both groups exhibited an increase in oxygenated hemoglobin with increasing time normalized to task duration (p<0.001, Fig 3A and 3B). There was also a significant effect of time on the TOI (p<0.001, Fig 3C and 3D), however none of the measures showed significant group or group by time interaction effects. The correlations between systolic blood pressure and oxygenated hemoglobin were r = -0.38 (left region, p = 0.036) and -0.44 (right region, p = 0.016) for the non-obese group and r = -0.42 for both regions for the obese group (p = 0.031 and 0.033, respectively). Correlations between diastolic blood pressure and oxygenated hemoglobin were r = -0.72 (left region, p<0.001) and -0.49 (right region, p = 0.065) for the non-obese group while they were not significant for the obese group (r = -0.09 (left region, p = 0.67) and -0.17 (right region, p = 0.40).

Bottom Line: The non-obese group reached ~43% of their predicted maximal aerobic capacity as compared to ~34% in the obese group, with the non-obese working at a relatively higher workload and for more duration than the obese.The obese had elevated baseline heart rate and reduced whole-body oxygen uptake per body weight at baseline and task termination.However, both groups exhibited similar cerebral hemodynamics during recovery.

View Article: PubMed Central - PubMed

Affiliation: Industrial and Systems Engineering, University at Buffalo, Buffalo, New York, 14260, United States of America.

ABSTRACT
The objective of this study was to compare gas exchange, cardiac and cerebral hemodynamic responses between 10 non-obese and 10 obese men during submaximal work. With the increasing prevalence of obesity, there is a need to understand the impact of obesity on work-induced responses. Participants completed a step-wise incremental cycling until they reached 60% of their age-predicted maximum heart rate. Gas exchange, cardiac and pre-frontal cortex hemodynamic responses were simultaneously measured during rest, work, and recovery. The non-obese group reached ~43% of their predicted maximal aerobic capacity as compared to ~34% in the obese group, with the non-obese working at a relatively higher workload and for more duration than the obese. The obese had elevated baseline heart rate and reduced whole-body oxygen uptake per body weight at baseline and task termination. Other cardiac and cerebral responses, although increased from baseline, were similar between groups during submaximal effort. In the obese, during recovery oxygen uptake and heart-rate recovery were slowest; cardiac output and rate pressure product were greatest, and left ventricle ejection time was shortest. However, both groups exhibited similar cerebral hemodynamics during recovery. These finding imply that, irrespective of their low aerobic fitness, obesity does not impair myocardial performance and cerebrovascular function during graded submaximal work, however, recovery from a short duration of work was influenced by their fitness level. Since a majority of activities of daily living are performed at individual's submaximal level, understanding influence of obesity on submaximal work is critical.

No MeSH data available.


Related in: MedlinePlus