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Effects of Ncl. Basalis Meynert volume on the Trail-Making-Test are restricted to the left hemisphere.

Lammers F, Mobascher A, Musso F, Shah NJ, Warbrick T, Zaborszky L, Winterer G - Brain Behav (2015)

Bottom Line: We found a quadratic effect of the left CH4 subregion on performance of the TMT.Both extremes have detrimental effects on attention.Comparable nonlinear effects have already been reported in pharmacological studies on the effects cholinergic agonists on attention.

View Article: PubMed Central - PubMed

Affiliation: Department of Anaesthesiology and Surgical Intensive Care Medicine Charité - University Medicine Berlin Berlin Germany.

ABSTRACT

Background: Cortical acetylcholine released from cells in the basal forebrain facilitates cue detection and improves attentional performance. Cholinergic fibres to the cortex originate from the CH4 cell group, sometimes referred to as the Nucleus basalis of Meynert and the Nucleus subputaminalis of Ayala. The aim of this work was to investigate the effects of volumes of cholinergic nuclei on attention and executive function.

Methods: The volumes of CH4 and CH4p subregions were measured in a subgroup of 38 subjects (33.5 ± 11 years, 20 females) from a population-based cohort study of smokers and never-smokers who have undergone additional MR imaging. To define regions of interest, we applied a DARTEL-based procedure implemented in SPM8 and a validated probabilistic map of the basal forebrain. Attention and executive function were measured with Trail-Making Test (TMT A+B) and Stroop-Task.

Results: We found a quadratic effect of the left CH4 subregion on performance of the TMT. Extremely small as well as extremely large volumes are associated with poor test performance.

Conclusions: Our results indicate that a small CH4 volume predisposes for a hypocholinergic state, whereas an extremely large volume predisposes for a hypercholinergic state. Both extremes have detrimental effects on attention. Comparable nonlinear effects have already been reported in pharmacological studies on the effects cholinergic agonists on attention.

No MeSH data available.


Related in: MedlinePlus

Effects of the left CH4 volume on Trail‐Making Test (TMT) performance analysed in a linear (left) and quadratic (right) regression. The proportion of variance in TMT performance explained exclusively by the left CH4 volume is shown on the bottom left of each plot (R2). ** indicates a significant corrected P‐value for the quadratic term. The adjusted R2 for each test was larger for the quadratic (adj. R2TMT‐A = 0.361, adj. R2TMT‐B = 0.571) than the linear model (adj. R2TMT‐A = 0.332, adj. R2TMT‐B = 0.423), indicating an improvement of the model by using quadratic regression.
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brb3421-fig-0002: Effects of the left CH4 volume on Trail‐Making Test (TMT) performance analysed in a linear (left) and quadratic (right) regression. The proportion of variance in TMT performance explained exclusively by the left CH4 volume is shown on the bottom left of each plot (R2). ** indicates a significant corrected P‐value for the quadratic term. The adjusted R2 for each test was larger for the quadratic (adj. R2TMT‐A = 0.361, adj. R2TMT‐B = 0.571) than the linear model (adj. R2TMT‐A = 0.332, adj. R2TMT‐B = 0.423), indicating an improvement of the model by using quadratic regression.

Mentions: The linear models showed no significant main effects of the cholinergic subregions on TMT or Stroop‐Task. However, significant interactions of the left CH4 region and sex were found for all three tests (Stroop‐Task and TMT Part A and B). Sex moderated the effect of the right CH4 region on performance in TMT Part A. Details of main effects of subregion volumes on test performance as well as interactions with covariates are shown in Table 1. Partial regression plots pointed to a quadratic relationship of the left CH4 volume and performance in the TMT (see Fig. 2).


Effects of Ncl. Basalis Meynert volume on the Trail-Making-Test are restricted to the left hemisphere.

Lammers F, Mobascher A, Musso F, Shah NJ, Warbrick T, Zaborszky L, Winterer G - Brain Behav (2015)

Effects of the left CH4 volume on Trail‐Making Test (TMT) performance analysed in a linear (left) and quadratic (right) regression. The proportion of variance in TMT performance explained exclusively by the left CH4 volume is shown on the bottom left of each plot (R2). ** indicates a significant corrected P‐value for the quadratic term. The adjusted R2 for each test was larger for the quadratic (adj. R2TMT‐A = 0.361, adj. R2TMT‐B = 0.571) than the linear model (adj. R2TMT‐A = 0.332, adj. R2TMT‐B = 0.423), indicating an improvement of the model by using quadratic regression.
© Copyright Policy - creativeCommonsBy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4834944&req=5

brb3421-fig-0002: Effects of the left CH4 volume on Trail‐Making Test (TMT) performance analysed in a linear (left) and quadratic (right) regression. The proportion of variance in TMT performance explained exclusively by the left CH4 volume is shown on the bottom left of each plot (R2). ** indicates a significant corrected P‐value for the quadratic term. The adjusted R2 for each test was larger for the quadratic (adj. R2TMT‐A = 0.361, adj. R2TMT‐B = 0.571) than the linear model (adj. R2TMT‐A = 0.332, adj. R2TMT‐B = 0.423), indicating an improvement of the model by using quadratic regression.
Mentions: The linear models showed no significant main effects of the cholinergic subregions on TMT or Stroop‐Task. However, significant interactions of the left CH4 region and sex were found for all three tests (Stroop‐Task and TMT Part A and B). Sex moderated the effect of the right CH4 region on performance in TMT Part A. Details of main effects of subregion volumes on test performance as well as interactions with covariates are shown in Table 1. Partial regression plots pointed to a quadratic relationship of the left CH4 volume and performance in the TMT (see Fig. 2).

Bottom Line: We found a quadratic effect of the left CH4 subregion on performance of the TMT.Both extremes have detrimental effects on attention.Comparable nonlinear effects have already been reported in pharmacological studies on the effects cholinergic agonists on attention.

View Article: PubMed Central - PubMed

Affiliation: Department of Anaesthesiology and Surgical Intensive Care Medicine Charité - University Medicine Berlin Berlin Germany.

ABSTRACT

Background: Cortical acetylcholine released from cells in the basal forebrain facilitates cue detection and improves attentional performance. Cholinergic fibres to the cortex originate from the CH4 cell group, sometimes referred to as the Nucleus basalis of Meynert and the Nucleus subputaminalis of Ayala. The aim of this work was to investigate the effects of volumes of cholinergic nuclei on attention and executive function.

Methods: The volumes of CH4 and CH4p subregions were measured in a subgroup of 38 subjects (33.5 ± 11 years, 20 females) from a population-based cohort study of smokers and never-smokers who have undergone additional MR imaging. To define regions of interest, we applied a DARTEL-based procedure implemented in SPM8 and a validated probabilistic map of the basal forebrain. Attention and executive function were measured with Trail-Making Test (TMT A+B) and Stroop-Task.

Results: We found a quadratic effect of the left CH4 subregion on performance of the TMT. Extremely small as well as extremely large volumes are associated with poor test performance.

Conclusions: Our results indicate that a small CH4 volume predisposes for a hypocholinergic state, whereas an extremely large volume predisposes for a hypercholinergic state. Both extremes have detrimental effects on attention. Comparable nonlinear effects have already been reported in pharmacological studies on the effects cholinergic agonists on attention.

No MeSH data available.


Related in: MedlinePlus