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Effects of Ncl. Basalis Meynert volume on the Trail-Making-Test are restricted to the left hemisphere.

Lammers F, Mobascher A, Musso F, Shah NJ, Warbrick T, Zaborszky L, Winterer G - Brain Behav (2015)

Bottom Line: We found a quadratic effect of the left CH4 subregion on performance of the TMT.Both extremes have detrimental effects on attention.Comparable nonlinear effects have already been reported in pharmacological studies on the effects cholinergic agonists on attention.

View Article: PubMed Central - PubMed

Affiliation: Department of Anaesthesiology and Surgical Intensive Care Medicine Charité - University Medicine Berlin Berlin Germany.

ABSTRACT

Background: Cortical acetylcholine released from cells in the basal forebrain facilitates cue detection and improves attentional performance. Cholinergic fibres to the cortex originate from the CH4 cell group, sometimes referred to as the Nucleus basalis of Meynert and the Nucleus subputaminalis of Ayala. The aim of this work was to investigate the effects of volumes of cholinergic nuclei on attention and executive function.

Methods: The volumes of CH4 and CH4p subregions were measured in a subgroup of 38 subjects (33.5 ± 11 years, 20 females) from a population-based cohort study of smokers and never-smokers who have undergone additional MR imaging. To define regions of interest, we applied a DARTEL-based procedure implemented in SPM8 and a validated probabilistic map of the basal forebrain. Attention and executive function were measured with Trail-Making Test (TMT A+B) and Stroop-Task.

Results: We found a quadratic effect of the left CH4 subregion on performance of the TMT. Extremely small as well as extremely large volumes are associated with poor test performance.

Conclusions: Our results indicate that a small CH4 volume predisposes for a hypocholinergic state, whereas an extremely large volume predisposes for a hypercholinergic state. Both extremes have detrimental effects on attention. Comparable nonlinear effects have already been reported in pharmacological studies on the effects cholinergic agonists on attention.

No MeSH data available.


Segmentation example for one brain. The blue ROI refers to CH4, CH4p is shown in yellow. Slices were chosen with the intention to show that CH4p covers a cell cluster often referred to as the Nucleus subputaminalis of Ayala which is rostrolateral extension of the NBM (at 12, 14 and 15 mm). Slice positions are indicated with reference to the most anterior slice on the top left.
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brb3421-fig-0001: Segmentation example for one brain. The blue ROI refers to CH4, CH4p is shown in yellow. Slices were chosen with the intention to show that CH4p covers a cell cluster often referred to as the Nucleus subputaminalis of Ayala which is rostrolateral extension of the NBM (at 12, 14 and 15 mm). Slice positions are indicated with reference to the most anterior slice on the top left.

Mentions: Segmentation results for one subject are shown in Figure 1. According to the Kolmogorov‐Smirnov‐test, we could not reject the assumption of normal distribution for test performance (pTMT‐A = 0.976, pTMT‐B = 0.728, pStroop = 0.336). VIFs were below the threshold of 2.5 in all analyses.


Effects of Ncl. Basalis Meynert volume on the Trail-Making-Test are restricted to the left hemisphere.

Lammers F, Mobascher A, Musso F, Shah NJ, Warbrick T, Zaborszky L, Winterer G - Brain Behav (2015)

Segmentation example for one brain. The blue ROI refers to CH4, CH4p is shown in yellow. Slices were chosen with the intention to show that CH4p covers a cell cluster often referred to as the Nucleus subputaminalis of Ayala which is rostrolateral extension of the NBM (at 12, 14 and 15 mm). Slice positions are indicated with reference to the most anterior slice on the top left.
© Copyright Policy - creativeCommonsBy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834944&req=5

brb3421-fig-0001: Segmentation example for one brain. The blue ROI refers to CH4, CH4p is shown in yellow. Slices were chosen with the intention to show that CH4p covers a cell cluster often referred to as the Nucleus subputaminalis of Ayala which is rostrolateral extension of the NBM (at 12, 14 and 15 mm). Slice positions are indicated with reference to the most anterior slice on the top left.
Mentions: Segmentation results for one subject are shown in Figure 1. According to the Kolmogorov‐Smirnov‐test, we could not reject the assumption of normal distribution for test performance (pTMT‐A = 0.976, pTMT‐B = 0.728, pStroop = 0.336). VIFs were below the threshold of 2.5 in all analyses.

Bottom Line: We found a quadratic effect of the left CH4 subregion on performance of the TMT.Both extremes have detrimental effects on attention.Comparable nonlinear effects have already been reported in pharmacological studies on the effects cholinergic agonists on attention.

View Article: PubMed Central - PubMed

Affiliation: Department of Anaesthesiology and Surgical Intensive Care Medicine Charité - University Medicine Berlin Berlin Germany.

ABSTRACT

Background: Cortical acetylcholine released from cells in the basal forebrain facilitates cue detection and improves attentional performance. Cholinergic fibres to the cortex originate from the CH4 cell group, sometimes referred to as the Nucleus basalis of Meynert and the Nucleus subputaminalis of Ayala. The aim of this work was to investigate the effects of volumes of cholinergic nuclei on attention and executive function.

Methods: The volumes of CH4 and CH4p subregions were measured in a subgroup of 38 subjects (33.5 ± 11 years, 20 females) from a population-based cohort study of smokers and never-smokers who have undergone additional MR imaging. To define regions of interest, we applied a DARTEL-based procedure implemented in SPM8 and a validated probabilistic map of the basal forebrain. Attention and executive function were measured with Trail-Making Test (TMT A+B) and Stroop-Task.

Results: We found a quadratic effect of the left CH4 subregion on performance of the TMT. Extremely small as well as extremely large volumes are associated with poor test performance.

Conclusions: Our results indicate that a small CH4 volume predisposes for a hypocholinergic state, whereas an extremely large volume predisposes for a hypercholinergic state. Both extremes have detrimental effects on attention. Comparable nonlinear effects have already been reported in pharmacological studies on the effects cholinergic agonists on attention.

No MeSH data available.