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Fatherhood contributes to increased hippocampal spine density and anxiety regulation in California mice.

Glasper ER, Hyer MM, Katakam J, Harper R, Ameri C, Wolz T - Brain Behav (2015)

Bottom Line: Parenting alters the hippocampus, an area of the brain that undergoes significant experience-induced plasticity and contributes to emotional regulation.Fatherhood also increased dendritic spine density of granule cells in the dentate gyrus and basal dendrites of pyramidal cells in area CA1 of the hippocampus.These findings parallel those observed in maternal rodents, suggesting that the hippocampus of fathers and mothers respond similarly to offspring.

View Article: PubMed Central - PubMed

Affiliation: Department of PsychologyUniversity of MarylandCollege ParkMaryland20742; Program in Neuroscience and Cognitive ScienceUniversity of MarylandCollege ParkMaryland20742.

ABSTRACT

Introduction: Parenting alters the hippocampus, an area of the brain that undergoes significant experience-induced plasticity and contributes to emotional regulation. While the relationship between maternal care and hippocampal neuroplasticity has been characterized, the extent to which fatherhood alters the structure and function of the hippocampus is far less understood.

Methods: Here, we investigated to what extent fatherhood altered anxiety regulation and dendritic morphology of the hippocampus using the highly paternal California mouse (Peromyscus californicus).

Results: Fathers spent significantly more time on the open arms of the elevated plus maze, compared to non-fathers. Total distance traveled in the EPM was not changed by paternal experience, which suggests that the increased time spent on the open arms of the maze indicates decreased anxiety-like behavior. Fatherhood also increased dendritic spine density of granule cells in the dentate gyrus and basal dendrites of pyramidal cells in area CA1 of the hippocampus.

Conclusions: These findings parallel those observed in maternal rodents, suggesting that the hippocampus of fathers and mothers respond similarly to offspring.

No MeSH data available.


Related in: MedlinePlus

Fatherhood decreases anxiety‐like behavior in California mice. (A) Fatherhood increases the percent time spent in the open arms of the elevated plus maze (EPM), compared to non‐fathers. Heat maps indicate the average location of mice. Warmer colors represent more, while cooler colors represent less, time spent in a location on the EPM. Greater heat is observed on the open arm of the elevated plus maze in fathers. (B) No difference in the total distance traveled within the EPM was observed. (C) The number of entries into the open or closed arms did not differ between groups. Bars represent mean+SEM. *P ≤ 0.05.
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brb3416-fig-0001: Fatherhood decreases anxiety‐like behavior in California mice. (A) Fatherhood increases the percent time spent in the open arms of the elevated plus maze (EPM), compared to non‐fathers. Heat maps indicate the average location of mice. Warmer colors represent more, while cooler colors represent less, time spent in a location on the EPM. Greater heat is observed on the open arm of the elevated plus maze in fathers. (B) No difference in the total distance traveled within the EPM was observed. (C) The number of entries into the open or closed arms did not differ between groups. Bars represent mean+SEM. *P ≤ 0.05.

Mentions: Fatherhood significantly decreased anxiety‐like behavior on the EPM. Increased percent time spent exploring the open arms of the EPM was observed among fathers, compared to non‐fathers (t (14) = 2.53, P ≤ 0.05; Fig. 1A). No differences in the total distance traveled within the EPM were observed (P > 0.05; Fig. 1B). Open and closed arm entries did not differ between groups (P > 0.05; Fig. 1C). Due to increased freezing behavior, three non‐fathers were excluded from the analyses. This likely increased the variance in open arm entries that may have prevented non‐fathers and fathers from being statistically different from each other.


Fatherhood contributes to increased hippocampal spine density and anxiety regulation in California mice.

Glasper ER, Hyer MM, Katakam J, Harper R, Ameri C, Wolz T - Brain Behav (2015)

Fatherhood decreases anxiety‐like behavior in California mice. (A) Fatherhood increases the percent time spent in the open arms of the elevated plus maze (EPM), compared to non‐fathers. Heat maps indicate the average location of mice. Warmer colors represent more, while cooler colors represent less, time spent in a location on the EPM. Greater heat is observed on the open arm of the elevated plus maze in fathers. (B) No difference in the total distance traveled within the EPM was observed. (C) The number of entries into the open or closed arms did not differ between groups. Bars represent mean+SEM. *P ≤ 0.05.
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brb3416-fig-0001: Fatherhood decreases anxiety‐like behavior in California mice. (A) Fatherhood increases the percent time spent in the open arms of the elevated plus maze (EPM), compared to non‐fathers. Heat maps indicate the average location of mice. Warmer colors represent more, while cooler colors represent less, time spent in a location on the EPM. Greater heat is observed on the open arm of the elevated plus maze in fathers. (B) No difference in the total distance traveled within the EPM was observed. (C) The number of entries into the open or closed arms did not differ between groups. Bars represent mean+SEM. *P ≤ 0.05.
Mentions: Fatherhood significantly decreased anxiety‐like behavior on the EPM. Increased percent time spent exploring the open arms of the EPM was observed among fathers, compared to non‐fathers (t (14) = 2.53, P ≤ 0.05; Fig. 1A). No differences in the total distance traveled within the EPM were observed (P > 0.05; Fig. 1B). Open and closed arm entries did not differ between groups (P > 0.05; Fig. 1C). Due to increased freezing behavior, three non‐fathers were excluded from the analyses. This likely increased the variance in open arm entries that may have prevented non‐fathers and fathers from being statistically different from each other.

Bottom Line: Parenting alters the hippocampus, an area of the brain that undergoes significant experience-induced plasticity and contributes to emotional regulation.Fatherhood also increased dendritic spine density of granule cells in the dentate gyrus and basal dendrites of pyramidal cells in area CA1 of the hippocampus.These findings parallel those observed in maternal rodents, suggesting that the hippocampus of fathers and mothers respond similarly to offspring.

View Article: PubMed Central - PubMed

Affiliation: Department of PsychologyUniversity of MarylandCollege ParkMaryland20742; Program in Neuroscience and Cognitive ScienceUniversity of MarylandCollege ParkMaryland20742.

ABSTRACT

Introduction: Parenting alters the hippocampus, an area of the brain that undergoes significant experience-induced plasticity and contributes to emotional regulation. While the relationship between maternal care and hippocampal neuroplasticity has been characterized, the extent to which fatherhood alters the structure and function of the hippocampus is far less understood.

Methods: Here, we investigated to what extent fatherhood altered anxiety regulation and dendritic morphology of the hippocampus using the highly paternal California mouse (Peromyscus californicus).

Results: Fathers spent significantly more time on the open arms of the elevated plus maze, compared to non-fathers. Total distance traveled in the EPM was not changed by paternal experience, which suggests that the increased time spent on the open arms of the maze indicates decreased anxiety-like behavior. Fatherhood also increased dendritic spine density of granule cells in the dentate gyrus and basal dendrites of pyramidal cells in area CA1 of the hippocampus.

Conclusions: These findings parallel those observed in maternal rodents, suggesting that the hippocampus of fathers and mothers respond similarly to offspring.

No MeSH data available.


Related in: MedlinePlus