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Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity.

Li W, Zhu J, Li Q, Ye J, Chen J, Liu J, Li Z, Li Y, Yan X, Wang Y, Wang W - Brain Behav (2016)

Bottom Line: Cognitive deficits caused by heroin-induced white matter (WM) impairments hinder addicts' engagement in and benefit from treatment.Compared with HA group, HR group had reduced FA in the right retrolenticular part, left anterior and posterior limb of internal capsule, bilateral anterior corona radiata, and right external capsule.Three out of the six regions showed increased RD, with no changes in AD.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology Tangdu Hospital The Fourth Military Medical University Xi'an Shaanxi China.

ABSTRACT

Introduction: Cognitive deficits caused by heroin-induced white matter (WM) impairments hinder addicts' engagement in and benefit from treatment. The predictive value of WM integrity in heroin addicts during methadone maintenance treatment (MMT) for future relapse is unclear.

Methods: Forty-eight MMT patients were given baseline diffusion tensor imaging scans and divided into heroin relapsers (HR, 25 cases) and abstainers (HA, 23 cases) according to the results of 6-month follow-up. Intergroup comparisons were performed for fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). The correlation between diffusion tensor imaging indices and the degree of heroin relapse was analyzed.

Results: Compared with HA group, HR group had reduced FA in the right retrolenticular part, left anterior and posterior limb of internal capsule, bilateral anterior corona radiata, and right external capsule. Three out of the six regions showed increased RD, with no changes in AD. The FA and AD values in the left posterior limb of internal capsule correlated negatively with the heroin-positive urinalysis rate within follow-up.

Conclusions: Lower WM integrity in MMT patients may add to neurobiological factors associated with relapse to heroin use. Strategies for improving WM integrity provide a new perspective to prevent future relapse to heroin abuse.

No MeSH data available.


Related in: MedlinePlus

Graphical presentation of significant correlations between the heroin‐positive urinalysis rate (corrected for age, years of education, duration and dosage of smoking, and heroin/methadone use) within 6‐month follow‐up after baseline and FA/AD values in the left posterior limb of internal capsule in heroin relapsers.
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brb3436-fig-0002: Graphical presentation of significant correlations between the heroin‐positive urinalysis rate (corrected for age, years of education, duration and dosage of smoking, and heroin/methadone use) within 6‐month follow‐up after baseline and FA/AD values in the left posterior limb of internal capsule in heroin relapsers.

Mentions: ROI‐based correlation analysis demonstrated that in HR group, the FA and AD values in the left posterior limb of internal capsule significantly negatively correlated with the heroin‐positive urinalysis rate within 6‐month follow‐up (r = −0.89, P < 0.001; r = −0.88, P < 0.001, survived after Bonferroni correction) (Fig. 2). No significant correlation between DTI indices and the heroin‐positive urinalysis rate was found in other ROIs. The logistic regression results showed that all of variates which showed significant intergroup difference had no significant effects on group membership. While we found that age were negatively correlated with the FA and AD values in anterior corona radiata (r = −0.44, P = 0.028 in right and r = −0.42, P = 0.037 in left) and in internal capsule (r = −0.43, P = 0.033 in left posterior limb of internal capsule and r = −0.35, P = 0.006 in left anterior limb of internal capsule). Duration of cigarette smoking were negatively correlated with the AD values in right retrolenticular part of internal capsule and left anterior limb of internal capsule (r = −0.33, P = 0.024 and r = −0.39, P = 0.006, respectively).


Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity.

Li W, Zhu J, Li Q, Ye J, Chen J, Liu J, Li Z, Li Y, Yan X, Wang Y, Wang W - Brain Behav (2016)

Graphical presentation of significant correlations between the heroin‐positive urinalysis rate (corrected for age, years of education, duration and dosage of smoking, and heroin/methadone use) within 6‐month follow‐up after baseline and FA/AD values in the left posterior limb of internal capsule in heroin relapsers.
© Copyright Policy - creativeCommonsBy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834937&req=5

brb3436-fig-0002: Graphical presentation of significant correlations between the heroin‐positive urinalysis rate (corrected for age, years of education, duration and dosage of smoking, and heroin/methadone use) within 6‐month follow‐up after baseline and FA/AD values in the left posterior limb of internal capsule in heroin relapsers.
Mentions: ROI‐based correlation analysis demonstrated that in HR group, the FA and AD values in the left posterior limb of internal capsule significantly negatively correlated with the heroin‐positive urinalysis rate within 6‐month follow‐up (r = −0.89, P < 0.001; r = −0.88, P < 0.001, survived after Bonferroni correction) (Fig. 2). No significant correlation between DTI indices and the heroin‐positive urinalysis rate was found in other ROIs. The logistic regression results showed that all of variates which showed significant intergroup difference had no significant effects on group membership. While we found that age were negatively correlated with the FA and AD values in anterior corona radiata (r = −0.44, P = 0.028 in right and r = −0.42, P = 0.037 in left) and in internal capsule (r = −0.43, P = 0.033 in left posterior limb of internal capsule and r = −0.35, P = 0.006 in left anterior limb of internal capsule). Duration of cigarette smoking were negatively correlated with the AD values in right retrolenticular part of internal capsule and left anterior limb of internal capsule (r = −0.33, P = 0.024 and r = −0.39, P = 0.006, respectively).

Bottom Line: Cognitive deficits caused by heroin-induced white matter (WM) impairments hinder addicts' engagement in and benefit from treatment.Compared with HA group, HR group had reduced FA in the right retrolenticular part, left anterior and posterior limb of internal capsule, bilateral anterior corona radiata, and right external capsule.Three out of the six regions showed increased RD, with no changes in AD.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology Tangdu Hospital The Fourth Military Medical University Xi'an Shaanxi China.

ABSTRACT

Introduction: Cognitive deficits caused by heroin-induced white matter (WM) impairments hinder addicts' engagement in and benefit from treatment. The predictive value of WM integrity in heroin addicts during methadone maintenance treatment (MMT) for future relapse is unclear.

Methods: Forty-eight MMT patients were given baseline diffusion tensor imaging scans and divided into heroin relapsers (HR, 25 cases) and abstainers (HA, 23 cases) according to the results of 6-month follow-up. Intergroup comparisons were performed for fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). The correlation between diffusion tensor imaging indices and the degree of heroin relapse was analyzed.

Results: Compared with HA group, HR group had reduced FA in the right retrolenticular part, left anterior and posterior limb of internal capsule, bilateral anterior corona radiata, and right external capsule. Three out of the six regions showed increased RD, with no changes in AD. The FA and AD values in the left posterior limb of internal capsule correlated negatively with the heroin-positive urinalysis rate within follow-up.

Conclusions: Lower WM integrity in MMT patients may add to neurobiological factors associated with relapse to heroin use. Strategies for improving WM integrity provide a new perspective to prevent future relapse to heroin abuse.

No MeSH data available.


Related in: MedlinePlus