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Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity.

Li W, Zhu J, Li Q, Ye J, Chen J, Liu J, Li Z, Li Y, Yan X, Wang Y, Wang W - Brain Behav (2016)

Bottom Line: Cognitive deficits caused by heroin-induced white matter (WM) impairments hinder addicts' engagement in and benefit from treatment.Compared with HA group, HR group had reduced FA in the right retrolenticular part, left anterior and posterior limb of internal capsule, bilateral anterior corona radiata, and right external capsule.Three out of the six regions showed increased RD, with no changes in AD.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology Tangdu Hospital The Fourth Military Medical University Xi'an Shaanxi China.

ABSTRACT

Introduction: Cognitive deficits caused by heroin-induced white matter (WM) impairments hinder addicts' engagement in and benefit from treatment. The predictive value of WM integrity in heroin addicts during methadone maintenance treatment (MMT) for future relapse is unclear.

Methods: Forty-eight MMT patients were given baseline diffusion tensor imaging scans and divided into heroin relapsers (HR, 25 cases) and abstainers (HA, 23 cases) according to the results of 6-month follow-up. Intergroup comparisons were performed for fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). The correlation between diffusion tensor imaging indices and the degree of heroin relapse was analyzed.

Results: Compared with HA group, HR group had reduced FA in the right retrolenticular part, left anterior and posterior limb of internal capsule, bilateral anterior corona radiata, and right external capsule. Three out of the six regions showed increased RD, with no changes in AD. The FA and AD values in the left posterior limb of internal capsule correlated negatively with the heroin-positive urinalysis rate within follow-up.

Conclusions: Lower WM integrity in MMT patients may add to neurobiological factors associated with relapse to heroin use. Strategies for improving WM integrity provide a new perspective to prevent future relapse to heroin abuse.

No MeSH data available.


Related in: MedlinePlus

TBSS analysis of fractional anisotropy (FA) between heroin relapsers (HR) and abstainers (HA). Red areas indicate where FA was significantly lower in HR group than in HA group (P < 0.05, corrected by TFCE and FWE). To help visualization, regions with reduced FA (red) were thickened using the ‘tbss_fill’ script implemented in FSL. Green color shows ‘group mean_FA_skeleton’ and the number below each brain image indicates Z coordinate in MNI space. The left side of the image corresponds to the right hemisphere of the brain.
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brb3436-fig-0001: TBSS analysis of fractional anisotropy (FA) between heroin relapsers (HR) and abstainers (HA). Red areas indicate where FA was significantly lower in HR group than in HA group (P < 0.05, corrected by TFCE and FWE). To help visualization, regions with reduced FA (red) were thickened using the ‘tbss_fill’ script implemented in FSL. Green color shows ‘group mean_FA_skeleton’ and the number below each brain image indicates Z coordinate in MNI space. The left side of the image corresponds to the right hemisphere of the brain.

Mentions: Fractional anisotropy was significantly lower in HR group than in HA group in the right retrolenticular part of internal capsule, left posterior limb of internal capsule, bilateral anterior corona radiata, left anterior limb of internal capsule, and right external capsule (P < 0.05, corrected by TFCE and FWE) (Fig. 1, Table 2). No WM regions showed significant reduction of FA in HA group compared with HR group.


Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity.

Li W, Zhu J, Li Q, Ye J, Chen J, Liu J, Li Z, Li Y, Yan X, Wang Y, Wang W - Brain Behav (2016)

TBSS analysis of fractional anisotropy (FA) between heroin relapsers (HR) and abstainers (HA). Red areas indicate where FA was significantly lower in HR group than in HA group (P < 0.05, corrected by TFCE and FWE). To help visualization, regions with reduced FA (red) were thickened using the ‘tbss_fill’ script implemented in FSL. Green color shows ‘group mean_FA_skeleton’ and the number below each brain image indicates Z coordinate in MNI space. The left side of the image corresponds to the right hemisphere of the brain.
© Copyright Policy - creativeCommonsBy
Related In: Results  -  Collection

License
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getmorefigures.php?uid=PMC4834937&req=5

brb3436-fig-0001: TBSS analysis of fractional anisotropy (FA) between heroin relapsers (HR) and abstainers (HA). Red areas indicate where FA was significantly lower in HR group than in HA group (P < 0.05, corrected by TFCE and FWE). To help visualization, regions with reduced FA (red) were thickened using the ‘tbss_fill’ script implemented in FSL. Green color shows ‘group mean_FA_skeleton’ and the number below each brain image indicates Z coordinate in MNI space. The left side of the image corresponds to the right hemisphere of the brain.
Mentions: Fractional anisotropy was significantly lower in HR group than in HA group in the right retrolenticular part of internal capsule, left posterior limb of internal capsule, bilateral anterior corona radiata, left anterior limb of internal capsule, and right external capsule (P < 0.05, corrected by TFCE and FWE) (Fig. 1, Table 2). No WM regions showed significant reduction of FA in HA group compared with HR group.

Bottom Line: Cognitive deficits caused by heroin-induced white matter (WM) impairments hinder addicts' engagement in and benefit from treatment.Compared with HA group, HR group had reduced FA in the right retrolenticular part, left anterior and posterior limb of internal capsule, bilateral anterior corona radiata, and right external capsule.Three out of the six regions showed increased RD, with no changes in AD.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology Tangdu Hospital The Fourth Military Medical University Xi'an Shaanxi China.

ABSTRACT

Introduction: Cognitive deficits caused by heroin-induced white matter (WM) impairments hinder addicts' engagement in and benefit from treatment. The predictive value of WM integrity in heroin addicts during methadone maintenance treatment (MMT) for future relapse is unclear.

Methods: Forty-eight MMT patients were given baseline diffusion tensor imaging scans and divided into heroin relapsers (HR, 25 cases) and abstainers (HA, 23 cases) according to the results of 6-month follow-up. Intergroup comparisons were performed for fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). The correlation between diffusion tensor imaging indices and the degree of heroin relapse was analyzed.

Results: Compared with HA group, HR group had reduced FA in the right retrolenticular part, left anterior and posterior limb of internal capsule, bilateral anterior corona radiata, and right external capsule. Three out of the six regions showed increased RD, with no changes in AD. The FA and AD values in the left posterior limb of internal capsule correlated negatively with the heroin-positive urinalysis rate within follow-up.

Conclusions: Lower WM integrity in MMT patients may add to neurobiological factors associated with relapse to heroin use. Strategies for improving WM integrity provide a new perspective to prevent future relapse to heroin abuse.

No MeSH data available.


Related in: MedlinePlus