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How electromagnetic fields can influence adult stem cells: positive and negative impacts.

Maziarz A, Kocan B, Bester M, Budzik S, Cholewa M, Ochiya T, Banas A - Stem Cell Res Ther (2016)

Bottom Line: In this article we review the current knowledge on the effects of EMFs on human adult stem cell biology, such as proliferation, the cell cycle, or differentiation.It has been demonstrated that the effects of EMF stimulation depend on the intensity and frequency of the EMF and the time of exposure to it.Exploration of this research area may enhance the development of EMF-based technologies used in medical applications and thereby improve stem cell-based therapy and tissue engineering.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Stem Cells' Biology, Department of Immunology, Chair of Molecular Medicine, Faculty of Medicine, University of Rzeszow, ul. Kopisto 2a, 35-310, Rzeszow, Poland.

ABSTRACT
The electromagnetic field (EMF) has a great impact on our body. It has been successfully used in physiotherapy for the treatment of bone disorders and osteoarthritis, as well as for cartilage regeneration or pain reduction. Recently, EMFs have also been applied in in vitro experiments on cell/stem cell cultures. Stem cells reside in almost all tissues within the human body, where they exhibit various potential. These cells are of great importance because they control homeostasis, regeneration, and healing. Nevertheless, stem cells when become cancer stem cells, may influence the pathological condition. In this article we review the current knowledge on the effects of EMFs on human adult stem cell biology, such as proliferation, the cell cycle, or differentiation. We present the characteristics of the EMFs used in miscellaneous assays. Most research has so far been performed during osteogenic and chondrogenic differentiation of mesenchymal stem cells. It has been demonstrated that the effects of EMF stimulation depend on the intensity and frequency of the EMF and the time of exposure to it. However, other factors may affect these processes, such as growth factors, reactive oxygen species, and so forth. Exploration of this research area may enhance the development of EMF-based technologies used in medical applications and thereby improve stem cell-based therapy and tissue engineering.

No MeSH data available.


Related in: MedlinePlus

Parameters of a sinusoidal EMF and b pulsed EMF mostly used in current studies together with references
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Fig4: Parameters of a sinusoidal EMF and b pulsed EMF mostly used in current studies together with references

Mentions: Scientific reports referring to the effects of the EMF on stem cell proliferation and the cell cycle have been inconsistent (Fig. 2a, b). Most research concerns human mesenchymal stem cells (MSCs). There have been numerous efforts to evaluate the effects of EMFs on different parameters; all of these are included and described precisely in Table 1. Consequently, we attempted to determine whether there is any general trend for selection of EMF characteristics and parameters in studies on human stem cell responses to EMF exposure (Fig. 3a, b). We gathered parameters of the EMF used in different studies for a sinusoidal EMF (Fig. 4a) and for a pulsed electromagnetic field (PEMF) (Fig. 4b).Fig. 3


How electromagnetic fields can influence adult stem cells: positive and negative impacts.

Maziarz A, Kocan B, Bester M, Budzik S, Cholewa M, Ochiya T, Banas A - Stem Cell Res Ther (2016)

Parameters of a sinusoidal EMF and b pulsed EMF mostly used in current studies together with references
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4834823&req=5

Fig4: Parameters of a sinusoidal EMF and b pulsed EMF mostly used in current studies together with references
Mentions: Scientific reports referring to the effects of the EMF on stem cell proliferation and the cell cycle have been inconsistent (Fig. 2a, b). Most research concerns human mesenchymal stem cells (MSCs). There have been numerous efforts to evaluate the effects of EMFs on different parameters; all of these are included and described precisely in Table 1. Consequently, we attempted to determine whether there is any general trend for selection of EMF characteristics and parameters in studies on human stem cell responses to EMF exposure (Fig. 3a, b). We gathered parameters of the EMF used in different studies for a sinusoidal EMF (Fig. 4a) and for a pulsed electromagnetic field (PEMF) (Fig. 4b).Fig. 3

Bottom Line: In this article we review the current knowledge on the effects of EMFs on human adult stem cell biology, such as proliferation, the cell cycle, or differentiation.It has been demonstrated that the effects of EMF stimulation depend on the intensity and frequency of the EMF and the time of exposure to it.Exploration of this research area may enhance the development of EMF-based technologies used in medical applications and thereby improve stem cell-based therapy and tissue engineering.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Stem Cells' Biology, Department of Immunology, Chair of Molecular Medicine, Faculty of Medicine, University of Rzeszow, ul. Kopisto 2a, 35-310, Rzeszow, Poland.

ABSTRACT
The electromagnetic field (EMF) has a great impact on our body. It has been successfully used in physiotherapy for the treatment of bone disorders and osteoarthritis, as well as for cartilage regeneration or pain reduction. Recently, EMFs have also been applied in in vitro experiments on cell/stem cell cultures. Stem cells reside in almost all tissues within the human body, where they exhibit various potential. These cells are of great importance because they control homeostasis, regeneration, and healing. Nevertheless, stem cells when become cancer stem cells, may influence the pathological condition. In this article we review the current knowledge on the effects of EMFs on human adult stem cell biology, such as proliferation, the cell cycle, or differentiation. We present the characteristics of the EMFs used in miscellaneous assays. Most research has so far been performed during osteogenic and chondrogenic differentiation of mesenchymal stem cells. It has been demonstrated that the effects of EMF stimulation depend on the intensity and frequency of the EMF and the time of exposure to it. However, other factors may affect these processes, such as growth factors, reactive oxygen species, and so forth. Exploration of this research area may enhance the development of EMF-based technologies used in medical applications and thereby improve stem cell-based therapy and tissue engineering.

No MeSH data available.


Related in: MedlinePlus