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Calorie restriction as an intervention in ageing.

López-Lluch G, Navas P - J. Physiol. (Lond.) (2016)

Bottom Line: CR produces a pleiotropic effect and improves multiple metabolic pathways, generating benefits to the whole organism.Finally, the anti-inflammatory effect of CR is an interesting emerging factor to be taken into consideration.In the present revision we focus on the general effect of CR and other mimetics in longevity, focusing especially on the cardiovascular system and skeletal muscle.

View Article: PubMed Central - PubMed

Affiliation: Universidad Pablo de Olavide, Centro Andaluz de Biología del Desarrollo, CABD-CSIC, CIBERER, Instituto de Salud Carlos III, Carretera de Utrera km. 1, 41013, Sevilla, Spain.

No MeSH data available.


Related in: MedlinePlus

Role of sirtuins in the control of mitochondrial physiologyThe increase in the NAD+/NADH ratio produced by CR in cells may induce the activity of the cytosolic SIRT1 and the mitochondrial SIRT3 forms. Both have been involved in the induction of many processes involved in the modulation of mitochondrial physiology such as induction of mitochondrial biogenesis by activating NOS and PGC‐1α, which, coupled with the activation of autophagy by deacetylation of FOXO3, promotes the renovation of mitochondria, eliminating damaged and unbalanced mitochondria at the same time as undamaged and active mitochondria increase. At the same time, lipid catabolism is promoted and the activity of mitochondrial antioxidants increases through the activity of SIRT3. Thus, sirtuins seem to be at the centre of mitochondrial modulation during CR.
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tjp6990-fig-0003: Role of sirtuins in the control of mitochondrial physiologyThe increase in the NAD+/NADH ratio produced by CR in cells may induce the activity of the cytosolic SIRT1 and the mitochondrial SIRT3 forms. Both have been involved in the induction of many processes involved in the modulation of mitochondrial physiology such as induction of mitochondrial biogenesis by activating NOS and PGC‐1α, which, coupled with the activation of autophagy by deacetylation of FOXO3, promotes the renovation of mitochondria, eliminating damaged and unbalanced mitochondria at the same time as undamaged and active mitochondria increase. At the same time, lipid catabolism is promoted and the activity of mitochondrial antioxidants increases through the activity of SIRT3. Thus, sirtuins seem to be at the centre of mitochondrial modulation during CR.

Mentions: Further research is needed to clarify the complex network of interactions and protein modifications involved in metabolism regulation induced by CR and related to a higher energetic efficiency. However, it is clear that regulation of sirtuins activities are, together with AMPK activity and PGC‐1α‐dependent pathways, at the centre of the response to CR (Fig. 3).


Calorie restriction as an intervention in ageing.

López-Lluch G, Navas P - J. Physiol. (Lond.) (2016)

Role of sirtuins in the control of mitochondrial physiologyThe increase in the NAD+/NADH ratio produced by CR in cells may induce the activity of the cytosolic SIRT1 and the mitochondrial SIRT3 forms. Both have been involved in the induction of many processes involved in the modulation of mitochondrial physiology such as induction of mitochondrial biogenesis by activating NOS and PGC‐1α, which, coupled with the activation of autophagy by deacetylation of FOXO3, promotes the renovation of mitochondria, eliminating damaged and unbalanced mitochondria at the same time as undamaged and active mitochondria increase. At the same time, lipid catabolism is promoted and the activity of mitochondrial antioxidants increases through the activity of SIRT3. Thus, sirtuins seem to be at the centre of mitochondrial modulation during CR.
© Copyright Policy - creativeCommonsBy-nc-nd
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834802&req=5

tjp6990-fig-0003: Role of sirtuins in the control of mitochondrial physiologyThe increase in the NAD+/NADH ratio produced by CR in cells may induce the activity of the cytosolic SIRT1 and the mitochondrial SIRT3 forms. Both have been involved in the induction of many processes involved in the modulation of mitochondrial physiology such as induction of mitochondrial biogenesis by activating NOS and PGC‐1α, which, coupled with the activation of autophagy by deacetylation of FOXO3, promotes the renovation of mitochondria, eliminating damaged and unbalanced mitochondria at the same time as undamaged and active mitochondria increase. At the same time, lipid catabolism is promoted and the activity of mitochondrial antioxidants increases through the activity of SIRT3. Thus, sirtuins seem to be at the centre of mitochondrial modulation during CR.
Mentions: Further research is needed to clarify the complex network of interactions and protein modifications involved in metabolism regulation induced by CR and related to a higher energetic efficiency. However, it is clear that regulation of sirtuins activities are, together with AMPK activity and PGC‐1α‐dependent pathways, at the centre of the response to CR (Fig. 3).

Bottom Line: CR produces a pleiotropic effect and improves multiple metabolic pathways, generating benefits to the whole organism.Finally, the anti-inflammatory effect of CR is an interesting emerging factor to be taken into consideration.In the present revision we focus on the general effect of CR and other mimetics in longevity, focusing especially on the cardiovascular system and skeletal muscle.

View Article: PubMed Central - PubMed

Affiliation: Universidad Pablo de Olavide, Centro Andaluz de Biología del Desarrollo, CABD-CSIC, CIBERER, Instituto de Salud Carlos III, Carretera de Utrera km. 1, 41013, Sevilla, Spain.

No MeSH data available.


Related in: MedlinePlus