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Analysis on international scientific collaboration and research focus on depression field.

Wu Y, Long C, Duan ZG - Chin. Med. J. (2015)

View Article: PubMed Central - PubMed

Affiliation: School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, China.

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Depression is one of the most prevalent psychiatric diseases and significantly negatively impacts patients’ productivity, quality of life, and cognitive functions... By examining scientific collaboration, this article also identified hot topics in depression research, which represent the areas of focus that numerous researchers have decided to have substantial potential to prevent and cure this pervasive disease... The analysis of centrality revealed that Harvard University has the highest degree and betweenness centrality and the lowest closeness centrality... The betweeness centrality of the University of Toronto in Canada was third highest and the closeness centrality second highest, but its degree centrality did not appear in the top 10... It also indicated that the University of Toronto had access to lots of research resources and was closely connected to core institutions, but lacked robust communications with other institutions... Similarly, Kings College London in England had a high betweenness and closeness centrality, indicating that it maintained an important position in the network, but its degree centrality did not make the top 10... However, some countries, such as France, had many ties but not many papers, while others, such as Brazil, had many papers but few ties... Finally, we found that the three countries that engaged in international collaboration most frequently – USA, England, and Germany – also have the most number of publications... Using the cluster term and research direction, we identified seven research hotspots... The first research hotspot, diagnosis and assessment, was found in sub-network 0, 2, 3, 8, 9, 12, 13, 14, 15, 16, 19, 20, 25 and 26... Due to the complexity of this disease and the diversity of the patients that it affects, scientific collaboration plays an indispensable role in understanding and treating depression... Thus, this article used SNA to construct and analyze the structure of scientific collaboration in depression research at the levels of authors, institutions, and countries from 2003 to 2012... The neurotransmitters responsible for emotion and mental state, mainly 5-hydroxytryptamine, dopamine, and catecholamine caused insanity when their processes of composition, storage, release, and receptor binding were disrupted... This study laid the foundation for psychopharmacology, leading to neurotransmitters research that has guided the development of new generation psychotropic drugs... Further, identifying research focus within the field can help researchers navigate the forefront of depression research.

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Research focus on depression research. Cluster top terms in each sub-network: #0: Cancer pain inventory; #1: Symptom cluster; #2: Meta-analysis; #3: Omega-3; #4: Subgroup; #5: Inbreeding depression; #6: Downstream regulatory element antagonist modulator; #7: Cortical spreading depression; #8: Antidepressant treatment trial; #9: Ecstasy; #10: Familial risk factor; #11: Cytokine; #12: Arab emirate; #13: Pain; #14: Sleep quality; #15: Medication; #16: Future research; #17: Neurotics; #18: Serum level; #19: Ketamine; #20: Treatment-seeking behavior; #21: Neuropeptide; #22: Negative emotion; #23: Presynaptic serotonin function; #24: Major depression prevalence; #25: Individual patient data; #26: Controlled trial finding.
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Figure 6: Research focus on depression research. Cluster top terms in each sub-network: #0: Cancer pain inventory; #1: Symptom cluster; #2: Meta-analysis; #3: Omega-3; #4: Subgroup; #5: Inbreeding depression; #6: Downstream regulatory element antagonist modulator; #7: Cortical spreading depression; #8: Antidepressant treatment trial; #9: Ecstasy; #10: Familial risk factor; #11: Cytokine; #12: Arab emirate; #13: Pain; #14: Sleep quality; #15: Medication; #16: Future research; #17: Neurotics; #18: Serum level; #19: Ketamine; #20: Treatment-seeking behavior; #21: Neuropeptide; #22: Negative emotion; #23: Presynaptic serotonin function; #24: Major depression prevalence; #25: Individual patient data; #26: Controlled trial finding.

Mentions: In order to detect the research focus in depression field, we used CiteSpace, mapped the hierarchal clustering network of co-cited documents [Figure 6], and gained 27 sub-networks [Table 4]. We selected log-likelihood ratio and extracted the terms to identify each cluster. Using the cluster term and research direction, we identified seven research hotspots. The first research hotspot, diagnosis and assessment, was found in sub-network 0, 2, 3, 8, 9, 12, 13, 14, 15, 16, 19, 20, 25 and 26. Among these, sub-network 13 was the largest. The representative document in this sub-network, “The PHQ-9-Validity of a brief depression severity measure”,[12] was written by Kroenke K et al. in 2001. This study suggested that the PHQ-9 was criteria –based diagnoses of depressive disorders and also a reliable and valid measure of depression severity and a useful clinical and research tool. The second research hotspot, behavioral biology, was in sub-network 1, 4, and 5. Among these, sub-network 4 was the largest. The representative document in this sub-network was “Statement on memories of sexual abuse” written by American Psychiatric Association Board of Trustees in 1994.[13] The third research hotspot, neurotransmission, was in sub-network 6, 10, 17, and 18. Among these, sub-network 18 was the largest. The representative document in this sub-network, “Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants”,[14] was written by Santarelli et al. in 2003. The findings of this study suggested that the behavioral effects of chronic antidepressants may be mediated by stimulation of neurogenesis in the hippocampus. The fourth research hotspot, brain morphology, was in sub-network 7. The representative document, “Mechanisms of migraine aura revealed by functional MRI in human visual cortex”,[15] was written by Hadjikhani et al. in 2001. This study suggested that an electrophysiological event such as cortical spreading depression generated the aura in the human visual cortex. The fifth research hotspot, cognitive disorder, was in sub-network 11. The representative document, “Mini-mental state. A practical method for grading the cognitive state of patients for clinician”,[16] was written by Folstein et al. in 1975. The sixth research hotspot, treatment, was in sub-network 21 and 24. Between these two, sub-network 21 was larger. The representative document in this sub-network, “Depression: A new animal-model sensitive to antidepressant treatments”,[17] was written by Porsolt et al. in 1977. The seventh research hotspot, molecular genetics, was in sub-network 22 and 23. Between these two, sub-network 23 was larger. The representative document in this sub-network, “Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene”,[18] was written by Caspi et al. in 2003. This study provided evidence of a gene-by environment interaction, in which an individual's response to environmental insults was moderated by his or her genetic makeup.


Analysis on international scientific collaboration and research focus on depression field.

Wu Y, Long C, Duan ZG - Chin. Med. J. (2015)

Research focus on depression research. Cluster top terms in each sub-network: #0: Cancer pain inventory; #1: Symptom cluster; #2: Meta-analysis; #3: Omega-3; #4: Subgroup; #5: Inbreeding depression; #6: Downstream regulatory element antagonist modulator; #7: Cortical spreading depression; #8: Antidepressant treatment trial; #9: Ecstasy; #10: Familial risk factor; #11: Cytokine; #12: Arab emirate; #13: Pain; #14: Sleep quality; #15: Medication; #16: Future research; #17: Neurotics; #18: Serum level; #19: Ketamine; #20: Treatment-seeking behavior; #21: Neuropeptide; #22: Negative emotion; #23: Presynaptic serotonin function; #24: Major depression prevalence; #25: Individual patient data; #26: Controlled trial finding.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4834784&req=5

Figure 6: Research focus on depression research. Cluster top terms in each sub-network: #0: Cancer pain inventory; #1: Symptom cluster; #2: Meta-analysis; #3: Omega-3; #4: Subgroup; #5: Inbreeding depression; #6: Downstream regulatory element antagonist modulator; #7: Cortical spreading depression; #8: Antidepressant treatment trial; #9: Ecstasy; #10: Familial risk factor; #11: Cytokine; #12: Arab emirate; #13: Pain; #14: Sleep quality; #15: Medication; #16: Future research; #17: Neurotics; #18: Serum level; #19: Ketamine; #20: Treatment-seeking behavior; #21: Neuropeptide; #22: Negative emotion; #23: Presynaptic serotonin function; #24: Major depression prevalence; #25: Individual patient data; #26: Controlled trial finding.
Mentions: In order to detect the research focus in depression field, we used CiteSpace, mapped the hierarchal clustering network of co-cited documents [Figure 6], and gained 27 sub-networks [Table 4]. We selected log-likelihood ratio and extracted the terms to identify each cluster. Using the cluster term and research direction, we identified seven research hotspots. The first research hotspot, diagnosis and assessment, was found in sub-network 0, 2, 3, 8, 9, 12, 13, 14, 15, 16, 19, 20, 25 and 26. Among these, sub-network 13 was the largest. The representative document in this sub-network, “The PHQ-9-Validity of a brief depression severity measure”,[12] was written by Kroenke K et al. in 2001. This study suggested that the PHQ-9 was criteria –based diagnoses of depressive disorders and also a reliable and valid measure of depression severity and a useful clinical and research tool. The second research hotspot, behavioral biology, was in sub-network 1, 4, and 5. Among these, sub-network 4 was the largest. The representative document in this sub-network was “Statement on memories of sexual abuse” written by American Psychiatric Association Board of Trustees in 1994.[13] The third research hotspot, neurotransmission, was in sub-network 6, 10, 17, and 18. Among these, sub-network 18 was the largest. The representative document in this sub-network, “Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants”,[14] was written by Santarelli et al. in 2003. The findings of this study suggested that the behavioral effects of chronic antidepressants may be mediated by stimulation of neurogenesis in the hippocampus. The fourth research hotspot, brain morphology, was in sub-network 7. The representative document, “Mechanisms of migraine aura revealed by functional MRI in human visual cortex”,[15] was written by Hadjikhani et al. in 2001. This study suggested that an electrophysiological event such as cortical spreading depression generated the aura in the human visual cortex. The fifth research hotspot, cognitive disorder, was in sub-network 11. The representative document, “Mini-mental state. A practical method for grading the cognitive state of patients for clinician”,[16] was written by Folstein et al. in 1975. The sixth research hotspot, treatment, was in sub-network 21 and 24. Between these two, sub-network 21 was larger. The representative document in this sub-network, “Depression: A new animal-model sensitive to antidepressant treatments”,[17] was written by Porsolt et al. in 1977. The seventh research hotspot, molecular genetics, was in sub-network 22 and 23. Between these two, sub-network 23 was larger. The representative document in this sub-network, “Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene”,[18] was written by Caspi et al. in 2003. This study provided evidence of a gene-by environment interaction, in which an individual's response to environmental insults was moderated by his or her genetic makeup.

View Article: PubMed Central - PubMed

Affiliation: School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, China.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Depression is one of the most prevalent psychiatric diseases and significantly negatively impacts patients’ productivity, quality of life, and cognitive functions... By examining scientific collaboration, this article also identified hot topics in depression research, which represent the areas of focus that numerous researchers have decided to have substantial potential to prevent and cure this pervasive disease... The analysis of centrality revealed that Harvard University has the highest degree and betweenness centrality and the lowest closeness centrality... The betweeness centrality of the University of Toronto in Canada was third highest and the closeness centrality second highest, but its degree centrality did not appear in the top 10... It also indicated that the University of Toronto had access to lots of research resources and was closely connected to core institutions, but lacked robust communications with other institutions... Similarly, Kings College London in England had a high betweenness and closeness centrality, indicating that it maintained an important position in the network, but its degree centrality did not make the top 10... However, some countries, such as France, had many ties but not many papers, while others, such as Brazil, had many papers but few ties... Finally, we found that the three countries that engaged in international collaboration most frequently – USA, England, and Germany – also have the most number of publications... Using the cluster term and research direction, we identified seven research hotspots... The first research hotspot, diagnosis and assessment, was found in sub-network 0, 2, 3, 8, 9, 12, 13, 14, 15, 16, 19, 20, 25 and 26... Due to the complexity of this disease and the diversity of the patients that it affects, scientific collaboration plays an indispensable role in understanding and treating depression... Thus, this article used SNA to construct and analyze the structure of scientific collaboration in depression research at the levels of authors, institutions, and countries from 2003 to 2012... The neurotransmitters responsible for emotion and mental state, mainly 5-hydroxytryptamine, dopamine, and catecholamine caused insanity when their processes of composition, storage, release, and receptor binding were disrupted... This study laid the foundation for psychopharmacology, leading to neurotransmitters research that has guided the development of new generation psychotropic drugs... Further, identifying research focus within the field can help researchers navigate the forefront of depression research.

Show MeSH
Related in: MedlinePlus