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Upregulation of miR-1280 expression in non-small cell lung cancer tissues.

Xu LM, Li LQ, Li J, Li HW, Shen QB, Ping JL, Ma ZH, Zhong J, Dai LC - Chin. Med. J. (2015)

Bottom Line: Non-small cell lung cancer (NSCLC) is a prolific and high-mortality disease with few effective treatments.Enhanced predictive biomarkers such as microRNAs (miRNAs) are needed at the time of diagnosis to better tailor therapies for patients.The miR-1280 expression was significantly higher in the NSCLC tissues (0.084 ± 0.099) than distal normal tissues (0.014 ± 0.015, P = 0.009).

View Article: PubMed Central - PubMed

Affiliation: Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China.

ABSTRACT

Background: Non-small cell lung cancer (NSCLC) is a prolific and high-mortality disease with few effective treatments. Although the detection and surgical techniques for NSCLC continue to advance, the survival rate for the patients with NSCLC remains poor. Enhanced predictive biomarkers such as microRNAs (miRNAs) are needed at the time of diagnosis to better tailor therapies for patients. This study focused on the expression of miR-1280 in NSCLC tissues and distal normal tissues in order to explore the association between miR-1280 expression and NSCLC.

Methods: A total of 72 newly diagnosed primary NSCLC patients were enrolled in this study. Quantitative real-time polymerase chain reaction (PCR) was performed to identify the expression level of miR-1280 in the NSCLC tissues and distal normal tissues of these patients.

Results: The miR-1280 expression was significantly higher in the NSCLC tissues (0.084 ± 0.099) than distal normal tissues (0.014 ± 0.015, P = 0.009). In 54 patients (75%), the miR-1280 expression in the NSCLC tissues was upregulated (2-ΔΔct > 2), and no case showed a downregulation of miR-1280 expression.

Conclusions: The expression level of miR-1280 could be regarded as a biomarker for NSCLC.

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Related in: MedlinePlus

The expression levels of miR-1280 in nonsmall-cell lung cancer tissues and distal normal tissues. The miR-1280 expression was higher in lung cancer tissues than in distal normal tissues (P= 0.009).
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Figure 1: The expression levels of miR-1280 in nonsmall-cell lung cancer tissues and distal normal tissues. The miR-1280 expression was higher in lung cancer tissues than in distal normal tissues (P= 0.009).

Mentions: A total of 72 NSCLC patients were enrolled in this study. The clinical characteristics of these patients were presented in Table 1. The expression levels of miR-1280 in the NSCLC tissues and paired distal normal tissues were detected by quantitative real-time PCR, normalized by U48, and presented as 2−Δct.[14] According to statistical analysis, the data were normal distribution. The expression level of miR-1280 was significantly higher in NSCLC tissues (0.084 ± 0.099) than in the distal normal tissues (0.014 ± 0.015, P = 0.009) [Figure 1].


Upregulation of miR-1280 expression in non-small cell lung cancer tissues.

Xu LM, Li LQ, Li J, Li HW, Shen QB, Ping JL, Ma ZH, Zhong J, Dai LC - Chin. Med. J. (2015)

The expression levels of miR-1280 in nonsmall-cell lung cancer tissues and distal normal tissues. The miR-1280 expression was higher in lung cancer tissues than in distal normal tissues (P= 0.009).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834781&req=5

Figure 1: The expression levels of miR-1280 in nonsmall-cell lung cancer tissues and distal normal tissues. The miR-1280 expression was higher in lung cancer tissues than in distal normal tissues (P= 0.009).
Mentions: A total of 72 NSCLC patients were enrolled in this study. The clinical characteristics of these patients were presented in Table 1. The expression levels of miR-1280 in the NSCLC tissues and paired distal normal tissues were detected by quantitative real-time PCR, normalized by U48, and presented as 2−Δct.[14] According to statistical analysis, the data were normal distribution. The expression level of miR-1280 was significantly higher in NSCLC tissues (0.084 ± 0.099) than in the distal normal tissues (0.014 ± 0.015, P = 0.009) [Figure 1].

Bottom Line: Non-small cell lung cancer (NSCLC) is a prolific and high-mortality disease with few effective treatments.Enhanced predictive biomarkers such as microRNAs (miRNAs) are needed at the time of diagnosis to better tailor therapies for patients.The miR-1280 expression was significantly higher in the NSCLC tissues (0.084 ± 0.099) than distal normal tissues (0.014 ± 0.015, P = 0.009).

View Article: PubMed Central - PubMed

Affiliation: Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China.

ABSTRACT

Background: Non-small cell lung cancer (NSCLC) is a prolific and high-mortality disease with few effective treatments. Although the detection and surgical techniques for NSCLC continue to advance, the survival rate for the patients with NSCLC remains poor. Enhanced predictive biomarkers such as microRNAs (miRNAs) are needed at the time of diagnosis to better tailor therapies for patients. This study focused on the expression of miR-1280 in NSCLC tissues and distal normal tissues in order to explore the association between miR-1280 expression and NSCLC.

Methods: A total of 72 newly diagnosed primary NSCLC patients were enrolled in this study. Quantitative real-time polymerase chain reaction (PCR) was performed to identify the expression level of miR-1280 in the NSCLC tissues and distal normal tissues of these patients.

Results: The miR-1280 expression was significantly higher in the NSCLC tissues (0.084 ± 0.099) than distal normal tissues (0.014 ± 0.015, P = 0.009). In 54 patients (75%), the miR-1280 expression in the NSCLC tissues was upregulated (2-ΔΔct > 2), and no case showed a downregulation of miR-1280 expression.

Conclusions: The expression level of miR-1280 could be regarded as a biomarker for NSCLC.

Show MeSH
Related in: MedlinePlus