Limits...
Combining endometrium sampling device and SurePath preparation to screen for endometrial carcinoma: a validation study.

Wen J, Chen R, Zhao J, Dong Y, Yang X, Liao QP - Chin. Med. J. (2015)

Bottom Line: Histological samples were processed in routine pathology and stained by hematoxylin and eosin.Adequate specimens for cytology were obtained from 1458/1541 patients (96.3%), while adequate samples for pathology were obtained from 285/375 patients (76%).However, for postmenopausal women, 1006 of 1045 cytology (86.3%) were adequate, 153 of 238 histology (64.3%) were adequate, it was easier to collect cytological specimens than histological specimens (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China.

ABSTRACT

Background: The aim of this study was to compare specimen adequacy of SAP-1 provided for cytology with that of dilation and curettage (D & C) or hysteroscopy for histology, and evaluate the accuracy of combining endometrium sampling by SAP-1 and liquid-based cytology using SurePath preparation for screening endometrial carcinoma and its precursor.

Methods: Endometrial specimens from women (n = 1514) with risk factors were obtained using an SAP-1 device for cytological analysis; histological samples were obtained from 375 of these women who underwent D & C or hysteroscopy. Cytological specimens were prepared to liquid-based smear using SurePath technology and stained by Papanicolaou. Histological samples were processed in routine pathology and stained by hematoxylin and eosin.

Results: Adequate specimens for cytology were obtained from 1458/1541 patients (96.3%), while adequate samples for pathology were obtained from 285/375 patients (76%). However, for postmenopausal women, 1006 of 1045 cytology (86.3%) were adequate, 153 of 238 histology (64.3%) were adequate, it was easier to collect cytological specimens than histological specimens (P < 0.05). The accuracy of endometrial cytology for detecting endometrial carcinoma and its precursor was 92.4% (sensitivity, 73%; specificity, 95.8%; positive predictive value, 75%; and negative predictive value, 95.3%).

Conclusions: Endometrial cytology using SAP-1 sampling and SurePath preparation may be a reliable approach for screening patients with endometrial carcinoma and its precursor.

Show MeSH

Related in: MedlinePlus

Steps for obtaining samples using the SAP-1 device
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4834777&req=5

Figure 2: Steps for obtaining samples using the SAP-1 device

Mentions: The SAP-1 sampler measures approximately 3 mm in diameter and 25 cm in length. It consists of a flexible latex loop with spines on the side and a smooth tip to prevent injury to the myometrium. There is an outer protective sheath outside the loop to prevent contamination from cervical and vaginal cells. It is easy to operate and can be used in an outpatient setting, at health examination centers and in community hospitals. The operating steps are described in Figure 2.


Combining endometrium sampling device and SurePath preparation to screen for endometrial carcinoma: a validation study.

Wen J, Chen R, Zhao J, Dong Y, Yang X, Liao QP - Chin. Med. J. (2015)

Steps for obtaining samples using the SAP-1 device
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834777&req=5

Figure 2: Steps for obtaining samples using the SAP-1 device
Mentions: The SAP-1 sampler measures approximately 3 mm in diameter and 25 cm in length. It consists of a flexible latex loop with spines on the side and a smooth tip to prevent injury to the myometrium. There is an outer protective sheath outside the loop to prevent contamination from cervical and vaginal cells. It is easy to operate and can be used in an outpatient setting, at health examination centers and in community hospitals. The operating steps are described in Figure 2.

Bottom Line: Histological samples were processed in routine pathology and stained by hematoxylin and eosin.Adequate specimens for cytology were obtained from 1458/1541 patients (96.3%), while adequate samples for pathology were obtained from 285/375 patients (76%).However, for postmenopausal women, 1006 of 1045 cytology (86.3%) were adequate, 153 of 238 histology (64.3%) were adequate, it was easier to collect cytological specimens than histological specimens (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China.

ABSTRACT

Background: The aim of this study was to compare specimen adequacy of SAP-1 provided for cytology with that of dilation and curettage (D & C) or hysteroscopy for histology, and evaluate the accuracy of combining endometrium sampling by SAP-1 and liquid-based cytology using SurePath preparation for screening endometrial carcinoma and its precursor.

Methods: Endometrial specimens from women (n = 1514) with risk factors were obtained using an SAP-1 device for cytological analysis; histological samples were obtained from 375 of these women who underwent D & C or hysteroscopy. Cytological specimens were prepared to liquid-based smear using SurePath technology and stained by Papanicolaou. Histological samples were processed in routine pathology and stained by hematoxylin and eosin.

Results: Adequate specimens for cytology were obtained from 1458/1541 patients (96.3%), while adequate samples for pathology were obtained from 285/375 patients (76%). However, for postmenopausal women, 1006 of 1045 cytology (86.3%) were adequate, 153 of 238 histology (64.3%) were adequate, it was easier to collect cytological specimens than histological specimens (P < 0.05). The accuracy of endometrial cytology for detecting endometrial carcinoma and its precursor was 92.4% (sensitivity, 73%; specificity, 95.8%; positive predictive value, 75%; and negative predictive value, 95.3%).

Conclusions: Endometrial cytology using SAP-1 sampling and SurePath preparation may be a reliable approach for screening patients with endometrial carcinoma and its precursor.

Show MeSH
Related in: MedlinePlus