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Amide proton transfer magnetic resonance imaging of Alzheimer's disease at 3.0 Tesla: a preliminary study.

Wang R, Li SY, Chen M, Zhou JY, Peng DT, Zhang C, Dai YM - Chin. Med. J. (2015)

Bottom Line: The magnetic resonance ratio asymmetry (MTR asym ) values at 3.5 ppm of bilateral hippocampi (Hc), temporal white matter regions, occipital white matter regions, and cerebral peduncles were measured on oblique axial APT images.MTR asym (3.5 ppm) values of the cerebral structures between AD patients and control subjects were compared with independent samples t-test.Compared with normal controls, MTR asym (3.5 ppm) values of bilateral Hc were significantly increased in AD patients (right 1.24% ± 0.21% vs. 0.83% ± 0.19%, left 1.18% ± 0.18% vs. 0.80%± 0.17%, t = 3.039, 3.328, P = 0.004, 0.002, respectively).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Beijing Hospital, Beijing 100730, China.

ABSTRACT

Background: Amide proton transfer (APT) imaging has recently emerged as an important contrast mechanism for magnetic resonance imaging (MRI) in the field of molecular and cellular imaging. The aim of this study was to evaluate the feasibility of APT imaging to detect cerebral abnormality in patients with Alzheimer's disease (AD) at 3.0 Tesla.

Methods: Twenty AD patients (9 men and 11 women; age range, 67-83 years) and 20 age-matched normal controls (11 men and 9 women; age range, 63-82 years) underwent APT and traditional MRI examination on a 3.0 Tesla MRI system. The magnetic resonance ratio asymmetry (MTR asym ) values at 3.5 ppm of bilateral hippocampi (Hc), temporal white matter regions, occipital white matter regions, and cerebral peduncles were measured on oblique axial APT images. MTR asym (3.5 ppm) values of the cerebral structures between AD patients and control subjects were compared with independent samples t-test. Controlling for age, partial correlation analysis was used to investigate the associations between mini-mental state examination (MMSE) and the various MRI measures among AD patients.

Results: Compared with normal controls, MTR asym (3.5 ppm) values of bilateral Hc were significantly increased in AD patients (right 1.24% ± 0.21% vs. 0.83% ± 0.19%, left 1.18% ± 0.18% vs. 0.80%± 0.17%, t = 3.039, 3.328, P = 0.004, 0.002, respectively). MTR asym (3.5 ppm) values of bilateral Hc were significantly negatively correlated with MMSE (right r = -0.559, P = 0.013; left r = -0.461, P = 0.047).

Conclusions: Increased MTR asym (3.5 ppm) values of bilateral Hc in AD patients and its strong correlations with MMSE suggest that APT imaging could potentially provide imaging biomarkers for the noninvasive molecular diagnosis of AD.

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Related in: MedlinePlus

Scatter of correlation between mini-mental state examination (MMSE) and magnetic resonance ratio asymmetry (MTRasym) (3.5 ppm) in right hippocampi (Hc) (a) and Scatter of correlation between MMSE and MTRasym (3.5 ppm) in left Hc (b). MTRasym (3.5 ppm) values of bilateral Hc both showed a negative correlation with MMSE.
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Figure 3: Scatter of correlation between mini-mental state examination (MMSE) and magnetic resonance ratio asymmetry (MTRasym) (3.5 ppm) in right hippocampi (Hc) (a) and Scatter of correlation between MMSE and MTRasym (3.5 ppm) in left Hc (b). MTRasym (3.5 ppm) values of bilateral Hc both showed a negative correlation with MMSE.

Mentions: Table 3 shows that the correlation coefficients for the relationships between MMSE scores and MTRasym (3.5 ppm) values of cerebral structures among AD patients. Partial correlation analysis revealed only MTRasym (3.5 ppm) values of bilateral Hc were significantly associated with MMSE (right r = −0.559, P = 0.013; left r = −0.461, P = 0.047). There were no correlations between MMSE and MTRasym (3.5 ppm) values in bilateral TWM, OWM, and CP. Scatters [Figure 3] demonstrated MTRasym (3.5 ppm) values of bilateral Hc were negatively correlated with MMSE.


Amide proton transfer magnetic resonance imaging of Alzheimer's disease at 3.0 Tesla: a preliminary study.

Wang R, Li SY, Chen M, Zhou JY, Peng DT, Zhang C, Dai YM - Chin. Med. J. (2015)

Scatter of correlation between mini-mental state examination (MMSE) and magnetic resonance ratio asymmetry (MTRasym) (3.5 ppm) in right hippocampi (Hc) (a) and Scatter of correlation between MMSE and MTRasym (3.5 ppm) in left Hc (b). MTRasym (3.5 ppm) values of bilateral Hc both showed a negative correlation with MMSE.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834771&req=5

Figure 3: Scatter of correlation between mini-mental state examination (MMSE) and magnetic resonance ratio asymmetry (MTRasym) (3.5 ppm) in right hippocampi (Hc) (a) and Scatter of correlation between MMSE and MTRasym (3.5 ppm) in left Hc (b). MTRasym (3.5 ppm) values of bilateral Hc both showed a negative correlation with MMSE.
Mentions: Table 3 shows that the correlation coefficients for the relationships between MMSE scores and MTRasym (3.5 ppm) values of cerebral structures among AD patients. Partial correlation analysis revealed only MTRasym (3.5 ppm) values of bilateral Hc were significantly associated with MMSE (right r = −0.559, P = 0.013; left r = −0.461, P = 0.047). There were no correlations between MMSE and MTRasym (3.5 ppm) values in bilateral TWM, OWM, and CP. Scatters [Figure 3] demonstrated MTRasym (3.5 ppm) values of bilateral Hc were negatively correlated with MMSE.

Bottom Line: The magnetic resonance ratio asymmetry (MTR asym ) values at 3.5 ppm of bilateral hippocampi (Hc), temporal white matter regions, occipital white matter regions, and cerebral peduncles were measured on oblique axial APT images.MTR asym (3.5 ppm) values of the cerebral structures between AD patients and control subjects were compared with independent samples t-test.Compared with normal controls, MTR asym (3.5 ppm) values of bilateral Hc were significantly increased in AD patients (right 1.24% ± 0.21% vs. 0.83% ± 0.19%, left 1.18% ± 0.18% vs. 0.80%± 0.17%, t = 3.039, 3.328, P = 0.004, 0.002, respectively).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Beijing Hospital, Beijing 100730, China.

ABSTRACT

Background: Amide proton transfer (APT) imaging has recently emerged as an important contrast mechanism for magnetic resonance imaging (MRI) in the field of molecular and cellular imaging. The aim of this study was to evaluate the feasibility of APT imaging to detect cerebral abnormality in patients with Alzheimer's disease (AD) at 3.0 Tesla.

Methods: Twenty AD patients (9 men and 11 women; age range, 67-83 years) and 20 age-matched normal controls (11 men and 9 women; age range, 63-82 years) underwent APT and traditional MRI examination on a 3.0 Tesla MRI system. The magnetic resonance ratio asymmetry (MTR asym ) values at 3.5 ppm of bilateral hippocampi (Hc), temporal white matter regions, occipital white matter regions, and cerebral peduncles were measured on oblique axial APT images. MTR asym (3.5 ppm) values of the cerebral structures between AD patients and control subjects were compared with independent samples t-test. Controlling for age, partial correlation analysis was used to investigate the associations between mini-mental state examination (MMSE) and the various MRI measures among AD patients.

Results: Compared with normal controls, MTR asym (3.5 ppm) values of bilateral Hc were significantly increased in AD patients (right 1.24% ± 0.21% vs. 0.83% ± 0.19%, left 1.18% ± 0.18% vs. 0.80%± 0.17%, t = 3.039, 3.328, P = 0.004, 0.002, respectively). MTR asym (3.5 ppm) values of bilateral Hc were significantly negatively correlated with MMSE (right r = -0.559, P = 0.013; left r = -0.461, P = 0.047).

Conclusions: Increased MTR asym (3.5 ppm) values of bilateral Hc in AD patients and its strong correlations with MMSE suggest that APT imaging could potentially provide imaging biomarkers for the noninvasive molecular diagnosis of AD.

Show MeSH
Related in: MedlinePlus