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Amide proton transfer magnetic resonance imaging of Alzheimer's disease at 3.0 Tesla: a preliminary study.

Wang R, Li SY, Chen M, Zhou JY, Peng DT, Zhang C, Dai YM - Chin. Med. J. (2015)

Bottom Line: The magnetic resonance ratio asymmetry (MTR asym ) values at 3.5 ppm of bilateral hippocampi (Hc), temporal white matter regions, occipital white matter regions, and cerebral peduncles were measured on oblique axial APT images.MTR asym (3.5 ppm) values of the cerebral structures between AD patients and control subjects were compared with independent samples t-test.Compared with normal controls, MTR asym (3.5 ppm) values of bilateral Hc were significantly increased in AD patients (right 1.24% ± 0.21% vs. 0.83% ± 0.19%, left 1.18% ± 0.18% vs. 0.80%± 0.17%, t = 3.039, 3.328, P = 0.004, 0.002, respectively).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Beijing Hospital, Beijing 100730, China.

ABSTRACT

Background: Amide proton transfer (APT) imaging has recently emerged as an important contrast mechanism for magnetic resonance imaging (MRI) in the field of molecular and cellular imaging. The aim of this study was to evaluate the feasibility of APT imaging to detect cerebral abnormality in patients with Alzheimer's disease (AD) at 3.0 Tesla.

Methods: Twenty AD patients (9 men and 11 women; age range, 67-83 years) and 20 age-matched normal controls (11 men and 9 women; age range, 63-82 years) underwent APT and traditional MRI examination on a 3.0 Tesla MRI system. The magnetic resonance ratio asymmetry (MTR asym ) values at 3.5 ppm of bilateral hippocampi (Hc), temporal white matter regions, occipital white matter regions, and cerebral peduncles were measured on oblique axial APT images. MTR asym (3.5 ppm) values of the cerebral structures between AD patients and control subjects were compared with independent samples t-test. Controlling for age, partial correlation analysis was used to investigate the associations between mini-mental state examination (MMSE) and the various MRI measures among AD patients.

Results: Compared with normal controls, MTR asym (3.5 ppm) values of bilateral Hc were significantly increased in AD patients (right 1.24% ± 0.21% vs. 0.83% ± 0.19%, left 1.18% ± 0.18% vs. 0.80%± 0.17%, t = 3.039, 3.328, P = 0.004, 0.002, respectively). MTR asym (3.5 ppm) values of bilateral Hc were significantly negatively correlated with MMSE (right r = -0.559, P = 0.013; left r = -0.461, P = 0.047).

Conclusions: Increased MTR asym (3.5 ppm) values of bilateral Hc in AD patients and its strong correlations with MMSE suggest that APT imaging could potentially provide imaging biomarkers for the noninvasive molecular diagnosis of AD.

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Related in: MedlinePlus

Fluid attenuated inversion recovery (FLAIR) image (a) and amide proton transfer (APT)-weighted image (b) of a typical normal control (female, 72 years old, mini-mental state examination [MMSE] score 29). FLAIR image (c) and APT image (d) of an Alzheimer's disease (AD) patient (female, 70 years old, MMSE score 16). Atrophy of bilateral hippocampi (Hc), enlarged lateral ventricles and widened sulci in AD were seen on the coronal FLAIR image. The APT-weighted intensities in regions of the Hc (white arrow) were higher in AD patients than in normal controls.
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Figure 2: Fluid attenuated inversion recovery (FLAIR) image (a) and amide proton transfer (APT)-weighted image (b) of a typical normal control (female, 72 years old, mini-mental state examination [MMSE] score 29). FLAIR image (c) and APT image (d) of an Alzheimer's disease (AD) patient (female, 70 years old, MMSE score 16). Atrophy of bilateral hippocampi (Hc), enlarged lateral ventricles and widened sulci in AD were seen on the coronal FLAIR image. The APT-weighted intensities in regions of the Hc (white arrow) were higher in AD patients than in normal controls.

Mentions: Two examples of the FLAIR images and APT-weighted images for a normal control and an AD patient were shown in Figure 2. Compared with the normal subject, we found marked atrophy and elevated APT-weighted intensities in both of the Hc in the AD patient.


Amide proton transfer magnetic resonance imaging of Alzheimer's disease at 3.0 Tesla: a preliminary study.

Wang R, Li SY, Chen M, Zhou JY, Peng DT, Zhang C, Dai YM - Chin. Med. J. (2015)

Fluid attenuated inversion recovery (FLAIR) image (a) and amide proton transfer (APT)-weighted image (b) of a typical normal control (female, 72 years old, mini-mental state examination [MMSE] score 29). FLAIR image (c) and APT image (d) of an Alzheimer's disease (AD) patient (female, 70 years old, MMSE score 16). Atrophy of bilateral hippocampi (Hc), enlarged lateral ventricles and widened sulci in AD were seen on the coronal FLAIR image. The APT-weighted intensities in regions of the Hc (white arrow) were higher in AD patients than in normal controls.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834771&req=5

Figure 2: Fluid attenuated inversion recovery (FLAIR) image (a) and amide proton transfer (APT)-weighted image (b) of a typical normal control (female, 72 years old, mini-mental state examination [MMSE] score 29). FLAIR image (c) and APT image (d) of an Alzheimer's disease (AD) patient (female, 70 years old, MMSE score 16). Atrophy of bilateral hippocampi (Hc), enlarged lateral ventricles and widened sulci in AD were seen on the coronal FLAIR image. The APT-weighted intensities in regions of the Hc (white arrow) were higher in AD patients than in normal controls.
Mentions: Two examples of the FLAIR images and APT-weighted images for a normal control and an AD patient were shown in Figure 2. Compared with the normal subject, we found marked atrophy and elevated APT-weighted intensities in both of the Hc in the AD patient.

Bottom Line: The magnetic resonance ratio asymmetry (MTR asym ) values at 3.5 ppm of bilateral hippocampi (Hc), temporal white matter regions, occipital white matter regions, and cerebral peduncles were measured on oblique axial APT images.MTR asym (3.5 ppm) values of the cerebral structures between AD patients and control subjects were compared with independent samples t-test.Compared with normal controls, MTR asym (3.5 ppm) values of bilateral Hc were significantly increased in AD patients (right 1.24% ± 0.21% vs. 0.83% ± 0.19%, left 1.18% ± 0.18% vs. 0.80%± 0.17%, t = 3.039, 3.328, P = 0.004, 0.002, respectively).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Beijing Hospital, Beijing 100730, China.

ABSTRACT

Background: Amide proton transfer (APT) imaging has recently emerged as an important contrast mechanism for magnetic resonance imaging (MRI) in the field of molecular and cellular imaging. The aim of this study was to evaluate the feasibility of APT imaging to detect cerebral abnormality in patients with Alzheimer's disease (AD) at 3.0 Tesla.

Methods: Twenty AD patients (9 men and 11 women; age range, 67-83 years) and 20 age-matched normal controls (11 men and 9 women; age range, 63-82 years) underwent APT and traditional MRI examination on a 3.0 Tesla MRI system. The magnetic resonance ratio asymmetry (MTR asym ) values at 3.5 ppm of bilateral hippocampi (Hc), temporal white matter regions, occipital white matter regions, and cerebral peduncles were measured on oblique axial APT images. MTR asym (3.5 ppm) values of the cerebral structures between AD patients and control subjects were compared with independent samples t-test. Controlling for age, partial correlation analysis was used to investigate the associations between mini-mental state examination (MMSE) and the various MRI measures among AD patients.

Results: Compared with normal controls, MTR asym (3.5 ppm) values of bilateral Hc were significantly increased in AD patients (right 1.24% ± 0.21% vs. 0.83% ± 0.19%, left 1.18% ± 0.18% vs. 0.80%± 0.17%, t = 3.039, 3.328, P = 0.004, 0.002, respectively). MTR asym (3.5 ppm) values of bilateral Hc were significantly negatively correlated with MMSE (right r = -0.559, P = 0.013; left r = -0.461, P = 0.047).

Conclusions: Increased MTR asym (3.5 ppm) values of bilateral Hc in AD patients and its strong correlations with MMSE suggest that APT imaging could potentially provide imaging biomarkers for the noninvasive molecular diagnosis of AD.

Show MeSH
Related in: MedlinePlus