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Amide proton transfer magnetic resonance imaging of Alzheimer's disease at 3.0 Tesla: a preliminary study.

Wang R, Li SY, Chen M, Zhou JY, Peng DT, Zhang C, Dai YM - Chin. Med. J. (2015)

Bottom Line: The magnetic resonance ratio asymmetry (MTR asym ) values at 3.5 ppm of bilateral hippocampi (Hc), temporal white matter regions, occipital white matter regions, and cerebral peduncles were measured on oblique axial APT images.MTR asym (3.5 ppm) values of the cerebral structures between AD patients and control subjects were compared with independent samples t-test.Compared with normal controls, MTR asym (3.5 ppm) values of bilateral Hc were significantly increased in AD patients (right 1.24% ± 0.21% vs. 0.83% ± 0.19%, left 1.18% ± 0.18% vs. 0.80%± 0.17%, t = 3.039, 3.328, P = 0.004, 0.002, respectively).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Beijing Hospital, Beijing 100730, China.

ABSTRACT

Background: Amide proton transfer (APT) imaging has recently emerged as an important contrast mechanism for magnetic resonance imaging (MRI) in the field of molecular and cellular imaging. The aim of this study was to evaluate the feasibility of APT imaging to detect cerebral abnormality in patients with Alzheimer's disease (AD) at 3.0 Tesla.

Methods: Twenty AD patients (9 men and 11 women; age range, 67-83 years) and 20 age-matched normal controls (11 men and 9 women; age range, 63-82 years) underwent APT and traditional MRI examination on a 3.0 Tesla MRI system. The magnetic resonance ratio asymmetry (MTR asym ) values at 3.5 ppm of bilateral hippocampi (Hc), temporal white matter regions, occipital white matter regions, and cerebral peduncles were measured on oblique axial APT images. MTR asym (3.5 ppm) values of the cerebral structures between AD patients and control subjects were compared with independent samples t-test. Controlling for age, partial correlation analysis was used to investigate the associations between mini-mental state examination (MMSE) and the various MRI measures among AD patients.

Results: Compared with normal controls, MTR asym (3.5 ppm) values of bilateral Hc were significantly increased in AD patients (right 1.24% ± 0.21% vs. 0.83% ± 0.19%, left 1.18% ± 0.18% vs. 0.80%± 0.17%, t = 3.039, 3.328, P = 0.004, 0.002, respectively). MTR asym (3.5 ppm) values of bilateral Hc were significantly negatively correlated with MMSE (right r = -0.559, P = 0.013; left r = -0.461, P = 0.047).

Conclusions: Increased MTR asym (3.5 ppm) values of bilateral Hc in AD patients and its strong correlations with MMSE suggest that APT imaging could potentially provide imaging biomarkers for the noninvasive molecular diagnosis of AD.

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Related in: MedlinePlus

T1-weighted image (a) and amide proton transfer image (b) were oblique axial planes along the long axis the hippocampi (Hc). Examples of the definition of the regions of interest for quantitative analysis (Brown: Temporal white matter; Purple: Occipital white matter; Black: Cerebral peduncle; Red: Hc).
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Figure 1: T1-weighted image (a) and amide proton transfer image (b) were oblique axial planes along the long axis the hippocampi (Hc). Examples of the definition of the regions of interest for quantitative analysis (Brown: Temporal white matter; Purple: Occipital white matter; Black: Cerebral peduncle; Red: Hc).

Mentions: The quantitative image analysis of APT was performed. The T1-weighted image was used as the anatomical reference to draw regions of interest (ROIs) of bilateral Hc, temporal white matter (TWM), occipital white matter (OWM) and cerebral peduncles (CPs) were measured on the oblique axial APT image, as shown in Figure 1. The ROIs were drawn to include as much of the measured tissues as possible while avoiding the adjacent cerebrospinal fluid (CSF) containing spaces to decrease partial volume effects from fluid. MTRasym (3.5 ppm) were measured for each region. Each Hc was manually traced to include the head, body, and tail of the Hc as described previously.[1719] The CP was chosen as a control region, in the vicinity of Hc but not typically affected in AD. Although AD is predominantly a gray matter disease, ROIs of bilateral TWM and OWM were outlined as white matter was also mildly damaged.[2414]


Amide proton transfer magnetic resonance imaging of Alzheimer's disease at 3.0 Tesla: a preliminary study.

Wang R, Li SY, Chen M, Zhou JY, Peng DT, Zhang C, Dai YM - Chin. Med. J. (2015)

T1-weighted image (a) and amide proton transfer image (b) were oblique axial planes along the long axis the hippocampi (Hc). Examples of the definition of the regions of interest for quantitative analysis (Brown: Temporal white matter; Purple: Occipital white matter; Black: Cerebral peduncle; Red: Hc).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834771&req=5

Figure 1: T1-weighted image (a) and amide proton transfer image (b) were oblique axial planes along the long axis the hippocampi (Hc). Examples of the definition of the regions of interest for quantitative analysis (Brown: Temporal white matter; Purple: Occipital white matter; Black: Cerebral peduncle; Red: Hc).
Mentions: The quantitative image analysis of APT was performed. The T1-weighted image was used as the anatomical reference to draw regions of interest (ROIs) of bilateral Hc, temporal white matter (TWM), occipital white matter (OWM) and cerebral peduncles (CPs) were measured on the oblique axial APT image, as shown in Figure 1. The ROIs were drawn to include as much of the measured tissues as possible while avoiding the adjacent cerebrospinal fluid (CSF) containing spaces to decrease partial volume effects from fluid. MTRasym (3.5 ppm) were measured for each region. Each Hc was manually traced to include the head, body, and tail of the Hc as described previously.[1719] The CP was chosen as a control region, in the vicinity of Hc but not typically affected in AD. Although AD is predominantly a gray matter disease, ROIs of bilateral TWM and OWM were outlined as white matter was also mildly damaged.[2414]

Bottom Line: The magnetic resonance ratio asymmetry (MTR asym ) values at 3.5 ppm of bilateral hippocampi (Hc), temporal white matter regions, occipital white matter regions, and cerebral peduncles were measured on oblique axial APT images.MTR asym (3.5 ppm) values of the cerebral structures between AD patients and control subjects were compared with independent samples t-test.Compared with normal controls, MTR asym (3.5 ppm) values of bilateral Hc were significantly increased in AD patients (right 1.24% ± 0.21% vs. 0.83% ± 0.19%, left 1.18% ± 0.18% vs. 0.80%± 0.17%, t = 3.039, 3.328, P = 0.004, 0.002, respectively).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Beijing Hospital, Beijing 100730, China.

ABSTRACT

Background: Amide proton transfer (APT) imaging has recently emerged as an important contrast mechanism for magnetic resonance imaging (MRI) in the field of molecular and cellular imaging. The aim of this study was to evaluate the feasibility of APT imaging to detect cerebral abnormality in patients with Alzheimer's disease (AD) at 3.0 Tesla.

Methods: Twenty AD patients (9 men and 11 women; age range, 67-83 years) and 20 age-matched normal controls (11 men and 9 women; age range, 63-82 years) underwent APT and traditional MRI examination on a 3.0 Tesla MRI system. The magnetic resonance ratio asymmetry (MTR asym ) values at 3.5 ppm of bilateral hippocampi (Hc), temporal white matter regions, occipital white matter regions, and cerebral peduncles were measured on oblique axial APT images. MTR asym (3.5 ppm) values of the cerebral structures between AD patients and control subjects were compared with independent samples t-test. Controlling for age, partial correlation analysis was used to investigate the associations between mini-mental state examination (MMSE) and the various MRI measures among AD patients.

Results: Compared with normal controls, MTR asym (3.5 ppm) values of bilateral Hc were significantly increased in AD patients (right 1.24% ± 0.21% vs. 0.83% ± 0.19%, left 1.18% ± 0.18% vs. 0.80%± 0.17%, t = 3.039, 3.328, P = 0.004, 0.002, respectively). MTR asym (3.5 ppm) values of bilateral Hc were significantly negatively correlated with MMSE (right r = -0.559, P = 0.013; left r = -0.461, P = 0.047).

Conclusions: Increased MTR asym (3.5 ppm) values of bilateral Hc in AD patients and its strong correlations with MMSE suggest that APT imaging could potentially provide imaging biomarkers for the noninvasive molecular diagnosis of AD.

Show MeSH
Related in: MedlinePlus