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The improvement of large High-Density Lipoprotein (HDL) particle levels, and presumably HDL metabolism, depend on effects of low-carbohydrate diet and weight loss.

Finelli C, Crispino P, Gioia S, La Sala N, D'amico L, La Grotta M, Miro O, Colarusso D - EXCLI J (2016)

Bottom Line: The objective of the study is to compare the effectiveness of low-carbohydrate diets and weight loss for increasing blood levels of large HDL particles at 1 year.Changes in HDL cholesterol concentration were modestly correlated with changes in large HDL particle concentration (r=0.47, p=.001).In conclusion, reduction of excess dietary carbohydrate and body weight improved large HDL levels.

View Article: PubMed Central - PubMed

Affiliation: Center of Obesity and Eating Disorders, Stella Maris Mediterraneum Foundation, Chiaromonte, Potenza, Italy.

ABSTRACT
Depressed levels of atheroprotective large HDL particles are common in obesity and cardiovascular disease (CVD). Increases in large HDL particles are favourably associated with reduced CVD event risk and coronary plaque burden. The objective of the study is to compare the effectiveness of low-carbohydrate diets and weight loss for increasing blood levels of large HDL particles at 1 year. This study was performed by screening for body mass index (BMI) and metabolic syndrome in 160 consecutive subjects referred to our out-patient Metabolic Unit in South Italy. We administered dietary advice to four small groups rather than individually. A single team comprised of a dietitian and physician administered diet-specific advice to each group. Large HDL particles at baseline and 1 year were measured using two-dimensional gel electrophoresis. Dietary intake was assessed via 3-day diet records. Although 1-year weight loss did not differ between diet groups (mean 4.4 %), increases in large HDL particles paralleled the degree of carbohydrate restriction across the four diets (p<0.001 for trend). Regression analysis indicated that magnitude of carbohydrate restriction (percentage of calories as carbohydrate at 1 year) and weight loss were each independent predictors of 1-year increases in large HDL concentration. Changes in HDL cholesterol concentration were modestly correlated with changes in large HDL particle concentration (r=0.47, p=.001). In conclusion, reduction of excess dietary carbohydrate and body weight improved large HDL levels. Comparison trials with cardiovascular outcomes are needed to more fully evaluate these findings.

No MeSH data available.


Related in: MedlinePlus

Baseline and one-year values for clinical variables in patients with 1-year data available for levels of large HDL*
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T1: Baseline and one-year values for clinical variables in patients with 1-year data available for levels of large HDL*

Mentions: Of 93 participants who completed the 1-year intervention, blood samples were available for analysis in 88 (n=20 in Atkins diet group; n=22 in Zone diet group; n=26 in Weight Watchers group; n=20 in Ornish diet group) cases (95 %). The mean age at baseline was 49 (SD=10) years, 43 (49 %) were male, and 67 (76 %) were Caucasian. For each diet group, absolute values at baseline and 1 year for relevant nutritional and biochemical cardiovascular risk variables are noted in Table 1(Tab. 1). Statistically significant macronutrient gradients (p < 0.05 for linear trend) across the four diets were present at 1 year for dietary carbohydrate, total fat, saturated fat, protein, fiber, and cholesterol.


The improvement of large High-Density Lipoprotein (HDL) particle levels, and presumably HDL metabolism, depend on effects of low-carbohydrate diet and weight loss.

Finelli C, Crispino P, Gioia S, La Sala N, D'amico L, La Grotta M, Miro O, Colarusso D - EXCLI J (2016)

Baseline and one-year values for clinical variables in patients with 1-year data available for levels of large HDL*
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834750&req=5

T1: Baseline and one-year values for clinical variables in patients with 1-year data available for levels of large HDL*
Mentions: Of 93 participants who completed the 1-year intervention, blood samples were available for analysis in 88 (n=20 in Atkins diet group; n=22 in Zone diet group; n=26 in Weight Watchers group; n=20 in Ornish diet group) cases (95 %). The mean age at baseline was 49 (SD=10) years, 43 (49 %) were male, and 67 (76 %) were Caucasian. For each diet group, absolute values at baseline and 1 year for relevant nutritional and biochemical cardiovascular risk variables are noted in Table 1(Tab. 1). Statistically significant macronutrient gradients (p < 0.05 for linear trend) across the four diets were present at 1 year for dietary carbohydrate, total fat, saturated fat, protein, fiber, and cholesterol.

Bottom Line: The objective of the study is to compare the effectiveness of low-carbohydrate diets and weight loss for increasing blood levels of large HDL particles at 1 year.Changes in HDL cholesterol concentration were modestly correlated with changes in large HDL particle concentration (r=0.47, p=.001).In conclusion, reduction of excess dietary carbohydrate and body weight improved large HDL levels.

View Article: PubMed Central - PubMed

Affiliation: Center of Obesity and Eating Disorders, Stella Maris Mediterraneum Foundation, Chiaromonte, Potenza, Italy.

ABSTRACT
Depressed levels of atheroprotective large HDL particles are common in obesity and cardiovascular disease (CVD). Increases in large HDL particles are favourably associated with reduced CVD event risk and coronary plaque burden. The objective of the study is to compare the effectiveness of low-carbohydrate diets and weight loss for increasing blood levels of large HDL particles at 1 year. This study was performed by screening for body mass index (BMI) and metabolic syndrome in 160 consecutive subjects referred to our out-patient Metabolic Unit in South Italy. We administered dietary advice to four small groups rather than individually. A single team comprised of a dietitian and physician administered diet-specific advice to each group. Large HDL particles at baseline and 1 year were measured using two-dimensional gel electrophoresis. Dietary intake was assessed via 3-day diet records. Although 1-year weight loss did not differ between diet groups (mean 4.4 %), increases in large HDL particles paralleled the degree of carbohydrate restriction across the four diets (p<0.001 for trend). Regression analysis indicated that magnitude of carbohydrate restriction (percentage of calories as carbohydrate at 1 year) and weight loss were each independent predictors of 1-year increases in large HDL concentration. Changes in HDL cholesterol concentration were modestly correlated with changes in large HDL particle concentration (r=0.47, p=.001). In conclusion, reduction of excess dietary carbohydrate and body weight improved large HDL levels. Comparison trials with cardiovascular outcomes are needed to more fully evaluate these findings.

No MeSH data available.


Related in: MedlinePlus