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A PER3 Polymorphism Interacts with Sleep Duration to Influence Transient Mood States in Women.

Viena TD, Gobin CM, Fins AI, Craddock TJ, Tartar A, Tartar JL - J Circadian Rhythms (2016)

Bottom Line: The PER3 genotype distribution was 88 (42.9%) for PER3(4/4), 98 (47.8%) for PER3(4/5), and 19 (9.3%) for PER3(5/5).Our sleep duration x genotype interaction analyses showed that, relative to longer allele carriers, PER3(4/4) genotypes were at greater risk for transient psychological effects (mood and state anxiety) when they reported reduced sleep durations.Sleep duration plays a critical role in understanding the extent to which PER3 allele status relates to mood states.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychology and Neuroscience, Nova Southeastern University, Ft. Lauderdale, FL USA.

ABSTRACT

Background: Expression of the clock family of genes in the suprachiasmatic nuclei (SCN) regulates the molecular control of circadian timing. Increasing evidence also implicates clock gene activity in the development of mood disorders. In particular, variation in the PER3 clock gene has been shown to influence diurnal preference and sleep homeostasis. However, there is not currently a clear association between PER3 polymorphisms and mood. This is possibly because the PER3 gene has been shown to influence homeostatic sleep drive, rather than circadian timing, and the PER3 gene may be behaviorally relevant only under chronic sleep loss conditions.

Methods: To test the association between PER3 allele status and impaired mood, a total of 205 healthy women were genotyped for PER3 allele status and responded to previously-validated psychological questionnaires surveying self-reported sleep habits (MEQ, PSQI) and mood. Our mood measures included two measures of short-term, transient mood (state anxiety and mood disturbance) and two measures of longer term, ongoing mood (trait anxiety and depressive symptomology).

Results: The PER3 genotype distribution was 88 (42.9%) for PER3(4/4), 98 (47.8%) for PER3(4/5), and 19 (9.3%) for PER3(5/5). Our sleep duration x genotype interaction analyses showed that, relative to longer allele carriers, PER3(4/4) genotypes were at greater risk for transient psychological effects (mood and state anxiety) when they reported reduced sleep durations.

Conclusion: Sleep duration plays a critical role in understanding the extent to which PER3 allele status relates to mood states.

No MeSH data available.


Related in: MedlinePlus

Relationship between sleep duration and mood impairment among PER3 groups. A main effect of sleep duration and total mood disturbance (POMS) was revealed (F (1,204) = 5.41, p = 0.02). A main effect of state anxiety (STAI-State) and sleep duration was also found (F (1,204) = 7.32, p = 0.007). There was no significant main effect of PER3 genotype alone on either the POMS or STAI measures (p’s > 0.05). Additionally, a significant interaction between PER3 genotype and sleep duration on the POMS scale (F (1,204) = 4.96, p = 0.03), and PER3 genotype and sleep duration on the state anxiety score (F (1,204) = 4.07, p = 0.04) was discovered. Neither depressive symptomatology (CES-D) nor trait anxiety (STAI-Trait) scores showed significant main effects of genotype or sleep duration or significant interaction effects (all p’s > 0.05). Values reflect means ± SEM.
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Figure 1: Relationship between sleep duration and mood impairment among PER3 groups. A main effect of sleep duration and total mood disturbance (POMS) was revealed (F (1,204) = 5.41, p = 0.02). A main effect of state anxiety (STAI-State) and sleep duration was also found (F (1,204) = 7.32, p = 0.007). There was no significant main effect of PER3 genotype alone on either the POMS or STAI measures (p’s > 0.05). Additionally, a significant interaction between PER3 genotype and sleep duration on the POMS scale (F (1,204) = 4.96, p = 0.03), and PER3 genotype and sleep duration on the state anxiety score (F (1,204) = 4.07, p = 0.04) was discovered. Neither depressive symptomatology (CES-D) nor trait anxiety (STAI-Trait) scores showed significant main effects of genotype or sleep duration or significant interaction effects (all p’s > 0.05). Values reflect means ± SEM.

Mentions: Our hypothesis that there would be an interaction between short sleep duration and mood impairments in the PER3 short allele carrier group was partially supported. As shown in Figure 1, only the measures of transient mood states (STAI-state, POMS) showed significant genotype by mood assessment interactions. For the POMS measure, there was a significant main effect for self-reported average hours of sleep, F (1,204) = 5.41, p = 0.02. The group that slept 6 hours or less per night had greater total mood disturbance (M = 29.58, SE = 3.06) than the group who reported sleeping more than 6 hours per night (M = 19.97, SE = 2.78). There was not a significant main effect for PER3 genotype alone (p > 0.05). There was a significant interaction between the PER3 genotype and sleep duration on the POMS total mood disturbance score F (1,204) = 4.96, p = 0.03. On the STAI measure (state and trait anxiety), the state anxiety measure, reflecting general anxiety during the experimental testing situation, showed a significant main effect for sleep duration F (1,204) = 7.32, p = 0.007. In agreement with the POMS measure, those who report sleeping less than 6 hours per night had greater state anxiety (M = 43.68, SE = 1.37) than those who report sleeping more than 6 hours per night (M = 38.69, SE = 1.24). There was not a significant main effect for PER3 genotype on state anxiety scores (p > 0.05), but there was a significant interaction between PER3 genotype and sleep duration on state anxiety scores F (1,204) = 4.07, p = 0.04. Neither depressive symptomatology (CES-D) nor trait anxiety scores showed significant main effects of genotype or sleep duration or significant interaction effects (all p’s > 0.05).


A PER3 Polymorphism Interacts with Sleep Duration to Influence Transient Mood States in Women.

Viena TD, Gobin CM, Fins AI, Craddock TJ, Tartar A, Tartar JL - J Circadian Rhythms (2016)

Relationship between sleep duration and mood impairment among PER3 groups. A main effect of sleep duration and total mood disturbance (POMS) was revealed (F (1,204) = 5.41, p = 0.02). A main effect of state anxiety (STAI-State) and sleep duration was also found (F (1,204) = 7.32, p = 0.007). There was no significant main effect of PER3 genotype alone on either the POMS or STAI measures (p’s > 0.05). Additionally, a significant interaction between PER3 genotype and sleep duration on the POMS scale (F (1,204) = 4.96, p = 0.03), and PER3 genotype and sleep duration on the state anxiety score (F (1,204) = 4.07, p = 0.04) was discovered. Neither depressive symptomatology (CES-D) nor trait anxiety (STAI-Trait) scores showed significant main effects of genotype or sleep duration or significant interaction effects (all p’s > 0.05). Values reflect means ± SEM.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834748&req=5

Figure 1: Relationship between sleep duration and mood impairment among PER3 groups. A main effect of sleep duration and total mood disturbance (POMS) was revealed (F (1,204) = 5.41, p = 0.02). A main effect of state anxiety (STAI-State) and sleep duration was also found (F (1,204) = 7.32, p = 0.007). There was no significant main effect of PER3 genotype alone on either the POMS or STAI measures (p’s > 0.05). Additionally, a significant interaction between PER3 genotype and sleep duration on the POMS scale (F (1,204) = 4.96, p = 0.03), and PER3 genotype and sleep duration on the state anxiety score (F (1,204) = 4.07, p = 0.04) was discovered. Neither depressive symptomatology (CES-D) nor trait anxiety (STAI-Trait) scores showed significant main effects of genotype or sleep duration or significant interaction effects (all p’s > 0.05). Values reflect means ± SEM.
Mentions: Our hypothesis that there would be an interaction between short sleep duration and mood impairments in the PER3 short allele carrier group was partially supported. As shown in Figure 1, only the measures of transient mood states (STAI-state, POMS) showed significant genotype by mood assessment interactions. For the POMS measure, there was a significant main effect for self-reported average hours of sleep, F (1,204) = 5.41, p = 0.02. The group that slept 6 hours or less per night had greater total mood disturbance (M = 29.58, SE = 3.06) than the group who reported sleeping more than 6 hours per night (M = 19.97, SE = 2.78). There was not a significant main effect for PER3 genotype alone (p > 0.05). There was a significant interaction between the PER3 genotype and sleep duration on the POMS total mood disturbance score F (1,204) = 4.96, p = 0.03. On the STAI measure (state and trait anxiety), the state anxiety measure, reflecting general anxiety during the experimental testing situation, showed a significant main effect for sleep duration F (1,204) = 7.32, p = 0.007. In agreement with the POMS measure, those who report sleeping less than 6 hours per night had greater state anxiety (M = 43.68, SE = 1.37) than those who report sleeping more than 6 hours per night (M = 38.69, SE = 1.24). There was not a significant main effect for PER3 genotype on state anxiety scores (p > 0.05), but there was a significant interaction between PER3 genotype and sleep duration on state anxiety scores F (1,204) = 4.07, p = 0.04. Neither depressive symptomatology (CES-D) nor trait anxiety scores showed significant main effects of genotype or sleep duration or significant interaction effects (all p’s > 0.05).

Bottom Line: The PER3 genotype distribution was 88 (42.9%) for PER3(4/4), 98 (47.8%) for PER3(4/5), and 19 (9.3%) for PER3(5/5).Our sleep duration x genotype interaction analyses showed that, relative to longer allele carriers, PER3(4/4) genotypes were at greater risk for transient psychological effects (mood and state anxiety) when they reported reduced sleep durations.Sleep duration plays a critical role in understanding the extent to which PER3 allele status relates to mood states.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychology and Neuroscience, Nova Southeastern University, Ft. Lauderdale, FL USA.

ABSTRACT

Background: Expression of the clock family of genes in the suprachiasmatic nuclei (SCN) regulates the molecular control of circadian timing. Increasing evidence also implicates clock gene activity in the development of mood disorders. In particular, variation in the PER3 clock gene has been shown to influence diurnal preference and sleep homeostasis. However, there is not currently a clear association between PER3 polymorphisms and mood. This is possibly because the PER3 gene has been shown to influence homeostatic sleep drive, rather than circadian timing, and the PER3 gene may be behaviorally relevant only under chronic sleep loss conditions.

Methods: To test the association between PER3 allele status and impaired mood, a total of 205 healthy women were genotyped for PER3 allele status and responded to previously-validated psychological questionnaires surveying self-reported sleep habits (MEQ, PSQI) and mood. Our mood measures included two measures of short-term, transient mood (state anxiety and mood disturbance) and two measures of longer term, ongoing mood (trait anxiety and depressive symptomology).

Results: The PER3 genotype distribution was 88 (42.9%) for PER3(4/4), 98 (47.8%) for PER3(4/5), and 19 (9.3%) for PER3(5/5). Our sleep duration x genotype interaction analyses showed that, relative to longer allele carriers, PER3(4/4) genotypes were at greater risk for transient psychological effects (mood and state anxiety) when they reported reduced sleep durations.

Conclusion: Sleep duration plays a critical role in understanding the extent to which PER3 allele status relates to mood states.

No MeSH data available.


Related in: MedlinePlus