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Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes.

Phopin K, Sinthupoom N, Treeratanapiboon L, Kunwittaya S, Prachayasittikul S, Ruchirawat S, Prachayasittikul V - EXCLI J (2016)

Bottom Line: 8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities.Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities.The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.

View Article: PubMed Central - PubMed

Affiliation: Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.

ABSTRACT
8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.

No MeSH data available.


Twenty-six microorganisms used in antimicrobial testing
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T1: Twenty-six microorganisms used in antimicrobial testing

Mentions: Method of agar dilution was performed to study the antimicrobial activity as formerly described (Prachayasittikul et al., 2011[28]). All compounds were dissolved in dimethyl sulfoxide (DMSO), and were separately mixed with 1 mL of Mueller Hinton (MH) broth. Then, the final concentrations of 32-256 µg/mL were carried out by transferring the mixture to the MH agar, and the negative control was MH broth. The cell concentration of microbes used in this study was adjusted to 108 cells/mL in 0.9 % normal saline after the microbes were cultured at 37 °C for 24 h in the MH broth. The inhibitions of microbial growth were detected in each compound following the inoculation onto the MH agar, and incubation at 37 °C for 24 h. Twenty-four bacteria and two yeasts were tested as listed in Table 1(Tab. 1).


Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes.

Phopin K, Sinthupoom N, Treeratanapiboon L, Kunwittaya S, Prachayasittikul S, Ruchirawat S, Prachayasittikul V - EXCLI J (2016)

Twenty-six microorganisms used in antimicrobial testing
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834669&req=5

T1: Twenty-six microorganisms used in antimicrobial testing
Mentions: Method of agar dilution was performed to study the antimicrobial activity as formerly described (Prachayasittikul et al., 2011[28]). All compounds were dissolved in dimethyl sulfoxide (DMSO), and were separately mixed with 1 mL of Mueller Hinton (MH) broth. Then, the final concentrations of 32-256 µg/mL were carried out by transferring the mixture to the MH agar, and the negative control was MH broth. The cell concentration of microbes used in this study was adjusted to 108 cells/mL in 0.9 % normal saline after the microbes were cultured at 37 °C for 24 h in the MH broth. The inhibitions of microbial growth were detected in each compound following the inoculation onto the MH agar, and incubation at 37 °C for 24 h. Twenty-four bacteria and two yeasts were tested as listed in Table 1(Tab. 1).

Bottom Line: 8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities.Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities.The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.

View Article: PubMed Central - PubMed

Affiliation: Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.

ABSTRACT
8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.

No MeSH data available.