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Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes.

Phopin K, Sinthupoom N, Treeratanapiboon L, Kunwittaya S, Prachayasittikul S, Ruchirawat S, Prachayasittikul V - EXCLI J (2016)

Bottom Line: 8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities.Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities.The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.

View Article: PubMed Central - PubMed

Affiliation: Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.

ABSTRACT
8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.

No MeSH data available.


Chemical structures of (a) 8AQ-5Iu (or 5Nu) metal complexes and (b) ligands
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Figure 2: Chemical structures of (a) 8AQ-5Iu (or 5Nu) metal complexes and (b) ligands

Mentions: 8AQ metal (Mn, Cu, Ni) complexes (1-6, Figure 2a(Fig. 2)) were synthesized and confirmed by spectral data by our group (Pingaew et al., 2013[27]). Chemical structures of free ligands 8AQ, 5-iodouracil (5Iu), and 5-nitrouracil (5Nu) are shown in Figure 2b(Fig. 2).


Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes.

Phopin K, Sinthupoom N, Treeratanapiboon L, Kunwittaya S, Prachayasittikul S, Ruchirawat S, Prachayasittikul V - EXCLI J (2016)

Chemical structures of (a) 8AQ-5Iu (or 5Nu) metal complexes and (b) ligands
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4834669&req=5

Figure 2: Chemical structures of (a) 8AQ-5Iu (or 5Nu) metal complexes and (b) ligands
Mentions: 8AQ metal (Mn, Cu, Ni) complexes (1-6, Figure 2a(Fig. 2)) were synthesized and confirmed by spectral data by our group (Pingaew et al., 2013[27]). Chemical structures of free ligands 8AQ, 5-iodouracil (5Iu), and 5-nitrouracil (5Nu) are shown in Figure 2b(Fig. 2).

Bottom Line: 8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities.Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities.The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.

View Article: PubMed Central - PubMed

Affiliation: Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.

ABSTRACT
8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.

No MeSH data available.