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Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

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a) Furfural was used as a feed material, alongside H2, in the twin‐column system. b) Hydrogenation products of furfural under supercritical conditions.
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fig3: a) Furfural was used as a feed material, alongside H2, in the twin‐column system. b) Hydrogenation products of furfural under supercritical conditions.

Mentions: In another study, the same group demonstrated a multicolumn reactor concept which enabled researchers to switch products formed in real‐time by changing the column conditions.14 Two packed reactor columns were placed in series, one containing copper chromate and the other Pd/C, each with its own H2 supply. A feed stream containing furfural (Figure 3 a) was mixed with CO2 before entering the first column. It was found that a range of products could be formed (Figure 3 b) in relatively high yields (>80 %) by adjusting the column temperatures and the amount of H2 supplied to each column in turn.


Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

a) Furfural was used as a feed material, alongside H2, in the twin‐column system. b) Hydrogenation products of furfural under supercritical conditions.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4834626&req=5

fig3: a) Furfural was used as a feed material, alongside H2, in the twin‐column system. b) Hydrogenation products of furfural under supercritical conditions.
Mentions: In another study, the same group demonstrated a multicolumn reactor concept which enabled researchers to switch products formed in real‐time by changing the column conditions.14 Two packed reactor columns were placed in series, one containing copper chromate and the other Pd/C, each with its own H2 supply. A feed stream containing furfural (Figure 3 a) was mixed with CO2 before entering the first column. It was found that a range of products could be formed (Figure 3 b) in relatively high yields (>80 %) by adjusting the column temperatures and the amount of H2 supplied to each column in turn.

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

Show MeSH
Related in: MedlinePlus