Machine-Assisted Organic Synthesis.
Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.
Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). email@example.com.Show MeSH
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Mentions: A recent publication reviewed the field of machine‐assisted coupled chemo(enzymatic) reactions in flow and commented on both the advantages and disadvantages of the process and where they perceive there to be future developments in this area.64 Others have focused on reactor design, particularly microstructured devices with enzymes to bring about improved biotransformations.65 An especially attractive novel microreactor was designed to enable heterogeneous reactions in a continuous mode, at up to 100 °C in toluene, through ring opening of ε‐caprolactone and its eventual polymerization.66 A packed bed flow reactor had also been used to bring about phosphorylation reactions of alcohols using cheap pyrophosphate as the transfer agent.67 Even more interesting was the use of a three‐step flow reactor cascade process to afford carbohydrate products through a phosphorylation/dephosphorylation sequence in quantities of up to a gram (Figure 14).68
Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). firstname.lastname@example.org.