Machine-Assisted Organic Synthesis.
Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.
Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). firstname.lastname@example.org.Show MeSH
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Mentions: A packed‐bed microreactor together with acetyl acetoin synthase (AAS) from Bacillus licheniformis immobilized on silica (Figure 15) nicely converted diketones into β‐ketohydroxyesters in high enantiomeric excess in the presence of thiamine diphosphate (ThDP).72
Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). email@example.com.