Limits...
Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

Show MeSH

Related in: MedlinePlus

Preparation of a β‐ketohydroxyester from a diketone using immobilized acetyl acetoin synthase.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4834626&req=5

fig15: Preparation of a β‐ketohydroxyester from a diketone using immobilized acetyl acetoin synthase.

Mentions: A packed‐bed microreactor together with acetyl acetoin synthase (AAS) from Bacillus licheniformis immobilized on silica (Figure 15) nicely converted diketones into β‐ketohydroxyesters in high enantiomeric excess in the presence of thiamine diphosphate (ThDP).72


Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Preparation of a β‐ketohydroxyester from a diketone using immobilized acetyl acetoin synthase.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4834626&req=5

fig15: Preparation of a β‐ketohydroxyester from a diketone using immobilized acetyl acetoin synthase.
Mentions: A packed‐bed microreactor together with acetyl acetoin synthase (AAS) from Bacillus licheniformis immobilized on silica (Figure 15) nicely converted diketones into β‐ketohydroxyesters in high enantiomeric excess in the presence of thiamine diphosphate (ThDP).72

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

Show MeSH
Related in: MedlinePlus