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Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

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A modular plate‐based microfluidic cell has been used for benzylic methoxylation and oxidation.
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fig22: A modular plate‐based microfluidic cell has been used for benzylic methoxylation and oxidation.

Mentions: Another example of both reactor design and exemplification through application include a direct continuous‐flow electrochemical procedure for benzylic methoxylation (4‐electron product) and oxidation (6‐electron product) by using a modular plate‐based microfluidic cell (Figure 22).93 This example is interesting, since it demonstrates how electrolysis at constant current, specifically in flow, enables control or, at best, modulation of substrate over‐oxidation by removal of the desired products.


Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ - Angew. Chem. Int. Ed. Engl. (2015)

A modular plate‐based microfluidic cell has been used for benzylic methoxylation and oxidation.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4834626&req=5

fig22: A modular plate‐based microfluidic cell has been used for benzylic methoxylation and oxidation.
Mentions: Another example of both reactor design and exemplification through application include a direct continuous‐flow electrochemical procedure for benzylic methoxylation (4‐electron product) and oxidation (6‐electron product) by using a modular plate‐based microfluidic cell (Figure 22).93 This example is interesting, since it demonstrates how electrolysis at constant current, specifically in flow, enables control or, at best, modulation of substrate over‐oxidation by removal of the desired products.

Bottom Line: In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors.Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods.All of these areas create both opportunities and challenges during adoption as enabling technologies.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). svl1000@cam.ac.uk.

Show MeSH
Related in: MedlinePlus